Four cases of uncommon tumours of the petrous bone treated by surgery alone or combined with radiotherapy are reported. There was one case embryonic sarcoma in a 3-year-old female child and one case each of chondroid chordoma, isolated plasmocytoma and malignant fibroid chondrosarcoma or histiocytoma with giant cells. The signal symptoms (pseudo-petrositis, isolated paralysis of a vocal cord, sudden deafness) may be misleading. The most helpful diagnostic methods are frontal tomography and CT scanning.

Child, Preschool↗

PubMed1981

[Epidermoid cyst of the orbit].

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Adult↗

PubMed1980

Extraneural metastases of astrocytomas and glioblastomas: clinicopathological study of two cases and review of literature.

Two cases of intracranial gliomas with extraneural metastases are described. Case 1, studied with biopsy material only, was a left malignant astrocytoma from the area of the rolandic fissure with right cervical lymph nodes metastases in a 43-year-old man. Case 2 was a left temporal malignant astrocytoma in a 21-year-old woman. Fifteen days after craniotomy, a left submandibular lymph node metastasis appeared. Forty days after surgery, a ventriculoperitoneal shunt was performed. Fifty-four days after surgery, the patient died. Autopsy revealed three liver metastases. Our review of the literature consists of 72 autopsy cases with extraneural deposits. Thos metastases occurred mainly in adults (63/72) and among men (46/72). The primary glioma was supratentorial in 67 cases. Metastases were mainly pulmonary and pleural. The majority of patients (82.8%) died within 2 years after onset of symptoms. In 8 of the cases, metastasis developed without any craniotomy and in 8 other cases, through a shunt.

Adolescent↗

PubMed1980

[Esthesioneuroblastoma: general review about three new cases (author's transl)].

The authors report three new cases of olfactory esthesioneuromas. They emphasise, both the surgical and radiotherapeutic methods used, and staging according to Kadish. Very localized forms may be treated either by surgery or radiotherapy. Less localized forms require association of surgery and radiotherapy, with a craniofacial combined approach when extension goes beyong the lamina cribosa.

Adolescent↗

PubMed1980

[Lymphomatoid granulomatosis: anatomo-clinical and ultrastructural study of two observations (author's transl)].

Two anatomoclinical observations of lymphomatoid granulomatosis are reported. The first case concerns a patient presenting a cutaneous localisation and a severe pulmonary infection with acute febrile dyspnea and macronodular opacities seen in pulmonary radiographs. The treatment associating cortisone and chlorambucil led to a complete remission. Five years later a pulmonary recurrence was treated successfully with the same association. The second patient presents dyspnea upon progressive effort, a radiologic and functional syndrome of interstitial involvement. In the absence of precise diagnosis after pulmonary biopsy, the patient was treated with corticosteroids. Four months later, encephalitic damage led to death. In the 2 observations, the biopsies or autopsic samples from the lungs or brain showed necrotic nodular lesions. Bordering on the necrosis, the small arteries and veins are strictured or obstructured by an infiltrate of lymphocytes, plasmocytes, histiocytes, and large cells with atypical nucleus. The ultrastructural examination of the 2 pulmonary biopsies shows the reactional polymorphic nature of the lymphoid infiltrate, the generally imprecise nature of atypical large cells and the modifications of vascular elastic limitations. The blades of elastine are surrounded by microfibrillar material. These different data are compared with those in the literature.

Adult↗

PubMed1980

[Nervous system and lymphomatoid granulomatosis. Clinical, pathological and nosological considerations (author's transl)].

This paper describes the first French case of lymphomatoid granulomatosis (LYG) in 46-year-old male. Autopsy revealed bilateral pulmonary involvement and multiple central nervous system (CNS) localizations. The originality of this study is due to 1st the scarcity of reported cases of LYG in Europe 2nd a detailed neuropathological study permitting diagnosis of multifocal central nervous involvement by LYG. In the literature only 12 previous cases of LYG have histologically proven CNS lesions. These lesions correspond to; 8 instances of LYG, one progressive multifocal leukencephalopathy,, one post-therapeutic disseminated necrotizing leukoencephalopathy, one immunoblastic sarcoma and one case of LYG associated with histiocytic malignant lymphoma. This paper also evokes clinical, histological, ultrastructural and prognostic characteristics of LYG gathered from the available literature. From a nosological point of view the relationship of LYG with Wegener granulomatosis, polymorphic reticulosis and certain lymphomas is still, to this day, not clearly established.

Adult↗

PubMed1979

[Hepatic lesions caused by vinyl chloride monomer in humans. Study of eight clinicopathological cases (author's transl)].

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Adult↗

PubMed1979

[The metastatic potential of primary central nervous tumours (author's transl)].

Anatomical and clinical findings in 9 cases of primary brain tumors with metastases within (7 cases) or outside of (2 cases) the nervous system are reported. A review of the published literature revealed 248 cases of histologically-confirmed central nervous system tumors with metastases outside of the nervous system. These secondary sites are seen more frequently in adult males. Their frequency, in descending order, was gliomas (39,5 p. 100), meningeal tumors and sarcomas (28,2 p. 100), neuronal tumors (14,1 p. 100), lymphoma-microgliomas (12,5 p. 100), pineal body tumors (4 p. 100), and melanomas (1,6 p. 100). Ten cases out of 248 developed through a shunt. Nineteen cases were discovered without any surgical operation. There are still many unknown factors concerning their pathogenesis. It appears, however, than in some series of patients the prolongation of the survival-rate and the late effects of surgical operation are positive factors for metastatic dissemination.

Adult↗

PubMed1979

[Extraneural metastasis of central nervous system tumours (author's transl)].

Extraneural metastases of central nervous system tumours are very rare (248 of histologically proven examples in the literature). They are mainly in adult males and in the following descending order of frequency: gliomas (39.5%), meningeal tumours and sarcomas (28.2%), neuronal tumours (14.1%), lymphomas-microgliomas (12.5%), pineal tumours (4%) and melanomas (1.6%); 10 cases out of 248 developed through a shunt. 19 were observed without any surgical operation. There are still many uncertainties about their pathogenesis. It seems however that in some tumours the increased survival time and the repetition of the craniotomy favorises the metastasis.

Adolescent↗

PubMed1979

[A case of thymolipoma in a child (author's transl)].

A new case of asymptomatic thymolipoma in a 4.5 years old girl is reported. It was discovered during systematic medical investigation. Its radiological characteristics and the lack of evolutivity made the authors suspect the diagnosis before operating. A total surgical extraction of the 300 g weighing tumor was performed through a right thoracotomy. No complication occurred in the post-operative time. Others authors already indicated the scarcity of this affection (less than 10 cases in children) as well as the special radiological characteristics of this tumor and the noticeable clinical tolerance often despite a large bulk. Histologically the tumor is made of an infiltrating of the normal thymic tissue by proliferating adipose adulte cells, the benignity of which is demonstrated by the evolution. In this study a differential diagnosis between thymolipoma and other mediastinal tumors is made and also some pathogenic assessments. Surgery always is required for treatment.

Child, Preschool↗

PubMed1978

Primary malignant melanoma of the cerebellum: a case with metastases outside the nervous system.

A case of primary intracranial melanoma in a 65-year-old female is described. A complete postmortem examination revealed multiple metastases in the liver, and eliminated the possibility of an extraneural primary melanoma. A review of the literature confirmed that such cases are highly exceptional, and that an exhaustive autopsy including particularly the eyes is indispensable to substantiate the diagnosis. When these conditions are fulfilled, there is no reason not to consider the eventuality of visceral deposits from a primary melanoma of the central nervous system.

Aged↗

PubMed1978

Sarcoma arising in oligodendroglioma of the brain: a case with intramedullary and subarachnoid spinal metastases.

A case of sarcoma arising in a left temporal oligodendroglioma is described in a 39-year-old male. The postoperative evolution was marked by a paraplegia linked to medullary and subarachnoid metastases. Then a relapse of the cerebral tumor occurred, and the patient died 6 months after the onset of the symptoms. Histologically, the mesenchymal component appeared fibrosarcomatous and angiosarcomatous. Those facts argue in favor of the histogenic hypotheses put forward in exceptional cases previously described, according to which the sarcoma develops from vascular elements of the glioma.

Adult↗