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Biomedical subjects

B P Davis

Publications and source records attributed to B P Davis.

30 records · Page 2Linked to original sources
PubMed1986

Transgenic progeny inherit tissue-specific expression of rat elastase I genes.

Six different lines of transgenic mice bearing rat elastase I genes stably inherit both the high-level pancreatic expression and low-level nonpancreatic expression characteristic of each original founding mouse. The high pancreatic expression of the introduced rat genes is transcriptionally determined. In response to high rat elastase I mRNA content in the pancreas, rat elastase I protein is synthesized and secreted at high levels. The stable inheritance of expression of the foreign rat elastase I genes in transgenic mice allows the development of animal lines that synthesize and secrete high levels of foreign protein by the pancreas.

Animals↗
PubMed1982

Conservative and chiropractic treatment of meralgia paresthetica: review and case report.

Meralgia paresthetica, a neuritis of the lateral femoral cutaneous nerve, appears to be usually a nerve entrapment syndrome but may also arise from other nerve insults or neuropathies. This paper reviews the anatomy of the affected nerve, differential diagnosis of the condition and the available treatments from conservative to surgical. The authors suggest that, because of failure to recognize it, the condition may be more prevalent than has been assumed, and they propose a role for chiropractic care in the sequence of management. This proposal is supported by a case report of a patient in which we describe our procedure for diagnosis of meralgia paresthetica and for monitoring progress; we then explain our course of conservative chiropractic treatment. That the symptoms of nine month's duration diminished progressively during six weeks of chiropractic treatment and have not returned in the six months post-treatment period offers no conclusive proof, but has encouraged us to investigate a larger sample of cases in our clinics.

Aged↗
PubMed1976

Inappropriate secretion of antidiuretic hormone after cerebral injury.

A case has been presented in which a patient sustained a closed head injury with concomitant maxillofacial injuries; early signs of water intoxication and ISADH developed six days after injury. This disorder was corrected by restricting free water intake for six days until equilibration occurred. Successful reduction of the facial fractures was accomplished after stabilization of the patient's neurological condition and correction of her metabolic disorder. The ISADH and resulting hyponatremia have been documented in a variety of disease states including trauma to the central nervous system. Disruption or irritation to the hypothalamic-neurohypophyseal system has been proposed as the mechanism of dysfunction after cerebral injury. The results of the secretion of inappropriate amounts of ADH relative to renal function and homeostatis have been discussed. Clinical and laboratory diagnosis as well as the elective and emergency management of ISADH have been reviewed. The fact that the sequelae of this abnormal metabolic state may mimic or mask the neurological deterioration which may follow cerebral injury is significant. This may contribute to the difficulty in making a correct diagnosis and designing proper therapy. The problem is basically one of differentiating a correctable metabolic disorder from a lesion that can be fatal unless surgically removed.

Adult↗
PubMedDate not supplied

Allele frequencies in a cat population in Budapest.

Allelic frequencies were determined for the domestic cat population of Budapest, Hungary. Most of the frequencies are in the range of those of western European populations, but there are two unusual features. The first is the apparent absence of blotched tabby and a relatively high frequency of Abyssinian tabby. The second is in the distribution of frequencies of white spotting phenotypes. There is an approximately normal distribution around the most common pattern, which is 50 percent white fur, contrasted to western populations in which frequency is maximal between approximately 10-30 percent white fur and declines with increasing white fur.

Alleles↗