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Biomedical subjects

B Oeseburg

Publications and source records attributed to B Oeseburg.

105 records · Page 6Linked to original sources

Intra-aortic decrease in blood plasma pH.

Using glass electrode catheters, a decrease in blood plasma pH was found in four dogs when the electrode at the tip of the catheter was passed from central to more peripheral sites of the arterial system. This findings can at least in part be explained by assuming that in the lung capillaries erythrocytes and plasma equilibrate separately with alveolar gas.

Animals↗

Continuous measurement of scalp tissue oxygen tension and carotid arterial oxygen tension in the fetal lamb.

Scalp tissue PO2, carotid arterial PO2 fetal heart rate were continuously measured in the anaesthetized fetal lamb in utero while variations in oxygen supply were brought about. In some experiments the transcutaneously measured fetal scalp PO2 was recorded in addition. Scalp tissue PO2 was measured using specially designed miniature needle-type oxygen electrode, incorporated in an easily applicable spiral scalp electrode as commonly used for fetal heart rate monitoring. The measurements showed that fetal carotid arterial hypoxaemia is always nearly immediately followed by fetal scalp tissue hypoxia, and that the recovery of scalp tissue PO2 after a hypoxic period has a remarkably varying time course. Fetal heart rate usually decreased during hypoxia, but in some instances it did not change or even increased, demonstrating that heart rate is not always a reliable indicator of fetal hypoxia. PO2 values obtained with the transcutaneous method were higher than those with the needle electrode, because of the effect of the heating system of the transcutaneous electrode on tissue blood flow and haemoglobin oxygen affinity. It would seem that during hypoxaemia the decrease in scalp tissue PO2 is poossibly the combined result of the fall in arterial PO2 and a concomitant decrease in blood flow through the skin.

Animals↗

Blood volume and hemoglobin after spinal cord injury.

OBJECTIVE: The main purpose of this study was to investigate the difference in total blood volume and hemoglobin mass between spinal cord-injured and able-bodied individuals. DESIGN: Total blood volumes of 13 able-bodied and 10 spinal cord-injured individuals (lesion >T4) were determined using the carbon monoxide method. The reproducibility of the total blood volume determination in our setting and the effect of increased physical activity were assessed. RESULTS: Comparison of groups showed a significantly higher hemoglobin mass in able-bodied compared with spinal cord-injured individuals. The total blood volume expressed per kilogram of body mass in able-bodied individuals was significantly greater than in spinal cord-injured individuals. CONCLUSIONS: These results suggest that total blood volume and hemoglobin mass are decreased in spinal cord-injured individuals with a lesion above T4, which may be related to their inactive lifestyle, because total blood volume increased with increased physical activity in these subjects.

Adult↗