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Biomedical subjects

B O'Neill

Publications and source records attributed to B O'Neill.

At least 91 records · Page 5Linked to original sources
PubMed1980

Xenotropic virus expression and susceptibility to 3-methylcholanthrene-induced cancer.

This paper reports the lack of genetic linkage between spontaneous production of substantial amounts of infectious xenotropic (X-tropic) virus and the susceptibility to chemically induced cancers in two inbred strains of mice, NZB/BLNJ and 129/J, and their genetic crosses. The parental strains and F1, backcross, and F2 progeny between these two strains were partially splenectomized to ascertain X-tropic viral status and were subsequently treated s.c. with 500 microgram of 3-methylcholanthrene in trioctanoin. Progeny from second backcrosses [(F1 X 129) X 129] were also tested for their X-tropic viral status and susceptibility to 3-methylcholanthrene carcinogenesis. Mice were observed for evidence of fibrosarcomas at the site of inoculation over a 10-month period. In this genetic system, spontaneous production of high titers of X-tropic virus segregated as a single autosomal dominant gene. Susceptibility to 3-methylcholanthrene-induced fibrosarcomas did not segregate in these crosses, and susceptibility did not correlate with the degree of X-tropic virus expression.

Animals↗
PubMed1980

Cerebral cortical atrophy in alcoholic men.

Sixteen alcoholic men under 50 with no gross evidence of intellectual impairment were evaluated by means of neurologic examination, neuropsychologic testing and computerized tomography. Computerized tomography demonstrated mild to moderate cortical atrophy in 11 of the 16 men when compared to an age-matched medical control group. The cortical atrophy was associated with evidence of memory and visual-motor impairment on neuropsychologic testing. The seriousness of the condition paralleled the length and intensity of alcohol abuse.

Adult↗
PubMed1979

Indexes of severity: underlying concepts--a reply.

A recent paper on the concepts underlying six indexes of severity that have been proposed for health services research claimed to identify deficiencies in each. A close examination reveals that the criticisms are generally without substance, and that the claim that the indexes "violate some of the principles implied by their formulation" is in error. Most of the objections apparently stem from fundamental confusion concerning the use of such indexes. Two of the indexes in question, the Abbreviated Injury Scale AIS) and the Injury Severity Score (ISS), have been validated and are being used widely both in the United States and elsewhere as the principal descriptors of trauma in motor vehicle crashes. The use of these indexes has contributed significantly to motor vehicle crash research and to the improvements in vehicles and highways that are reducing the trauma resulting from such crashes.

Abstracting and Indexing↗
PubMed1975

Are 1974-1975 automotive belt systems hazardous to children?

The 1974 and early-1975 model automobiles are equipped with belt interlock systems that require front outboard seat occupants who weigh more than 21.5 kg (47.3 lb) to wear threepoint lap and diagonal upper-torso belts (or wear the lap belt and position upper-torso belt behind them), assuming that the interlock has not been circumvented. Recent legislation has eliminated the interlock requirement, but new models are still likely to be fitted with three-point restraints for the front outboard seating positions. These restraint systems were designed and tested for adult use. Thus, based on the different structure of a younger child and the fact that there is a wide variation of belt orientation, child size, and seating environments, there is legitimate concern that the upper diagonal belt might contribute to injury of the child under certain impact conditions.

Adolescent↗