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Biomedical subjects

B Nowakowska

Publications and source records attributed to B Nowakowska.

25 records · Page 2Linked to original sources
PubMed1987

Association of HLA antigens with chronic active hepatitis (CAH) in children.

HLA-A and -B antigen frequencies were investigated in a group of 46 children with chronic active hepatitis (CAH) and in a control group of 100 healthy children. The diseased group comprised 43 HBsAg positive and 3 HBsAg negative children. From the antigen frequencies relative risks (RR) were calculated according to the method of Woolf. The A1 and B8 antigens, known to be associated with autoimmune diseases, were only moderately more frequent in the CAH group than in the control. The relative risk for B8 antigen was 2.23 which is near to a significance level of p = 0.05. When the calculations were performed for 43 HBsAg positive CAH children the RR decreased to 1.70. Additionally, observations were performed on associations of HLA antigens with the occurrence of antinuclear antibodies (ANA) and anti-smooth muscle antibodies (SMA). Positive associations were found for ANA with B13 antigen (RR = 14.13) and for SMA with B5 antigen (RR = 13.66) with X2 4.85, and 5.51 respectively, at 1 degree of freedom. The p values, situated between 0.05 and 0.01 were insignificant after the correction for the number of antigens studied.

Adolescent↗
PubMedDate not supplied

Double haploidentical transplantation of hematopoietic progenitor cells in a boy with myelodysplastic syndrome.

A 12-year-old boy with myelodysplastic syndrome underwent a double transplantation of hematopoietic progenitor cells from his haploidentical brother. After conditioning with busulfan, cyclophosphamide, and Vepesid, the first bone marrow transplantation was performed using 3.53 x 10(6)/kg of CD34+ cells. Initial engraftment was followed by graft rejection. The second conditioning consisted of melphalan and anti-thymocyte globulin. The boy was then transplanted with 5.15 x 10(6)/kg of CD34+ cells, harvested from bone marrow (BM) and peripheral blood. Graft versus host disease (GvHD) prophylaxis consisted of cyclosporine A + short methotrexate. Hematological recovery was rapid and stable. Acute GvHD 1 degree (skin) resolved after 2 weeks of steroid treatment. A relapse occurred on day +140. At that time NK cells decreased from 20 to 7% with the lowest CD4+/CD8+ ratio, 0.07. Just after relapse, the percentage of cytokine-induced killer cells (CIK-CD3+CD56+) dropped from 3.34 to 0.1%. CsA treatment was stopped and the patient received T cell (CD3+ cells) add-back four times on days +146, +199, +234, and +262 in doses of 0.5 x 10(5), 1.0 x 10(5), 2.0 x 10(5), and 4.0 x 10(5)/kg, respectively. No acute GvHD occurred. Additionally, bone marrow biopsy before the second add-back showed complete remission. Analysis of lymphocyte subsets before the fourth add-back showed the highest values of CD4+, NK, and CIK cells and also the highest CD4+/CD8+ ratio.

Child↗
PubMedDate not supplied

[Multiple sclerosis coexisting with myasthenia].

In a male patient multiple sclerosis was found to coexist with myasthenia. The symptoms of muscle fatiguability and of central nervous system damage developed at the same time. Multiple sclerosis was the predominating disease, especially in later stage of the disease. The authors discuss the possibility of a common immunological substrate for both conditions.

Brain↗