Thermoregulatory responses to arm work, leg work and intermittent leg work.
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Adult↗
Biomedical subjects
B Nielsen
Publications and source records attributed to B Nielsen.
A method for testing scattered radiation grids.
A simple method of evaluating contrast improvement factors and other related quantities has been developed. With this method a water or lucite phantom is imaged with a lead disk on a nonscreen film using a scattered radiation grid with unknown characteristics. The image is then compared with that obtained with the same arrangement but with a calibrated scattered radiation grid. The method described does not need sophisticated instruments and can be used in any department of diagnostic radiology
Technology, Radiologic↗
The calcium channel blocker nitrendipine attenuates renal and glomerular hypertrophy in diabetic rats.
The efficacy of the calcium channel blocker nitrendipine in preventing early renal and glomerular hypertrophy and increased urinary albumin excretion (UAE) was studied in experimental diabetes in rats, starting treatment at the onset of diabetes. Female Wistar rats were randomised into four groups: diabetic and non-diabetic rats were given either placebo or nitrendipine (250 mg/kg) in the diet for 8 weeks. After 8 weeks the kidneys in the diabetic animals had increased significantly compared to the non-diabetic controls. In the diabetic nitrendipine-treated animals renal and glomerular hypertrophy was significantly smaller than in the diabetic placebo-treated group (p < 0.05). After an initial increment within the first week, the UAE remained constant throughout the study period in the diabetic nitrendipine-treated animals, while a steady increase was seen in the diabetic placebo-treated group (p < 0.05). No differences were seen in systemic blood pressure between calcium- channel-blocker-treated groups and placebo-treated groups. In conclusion, administration of nitrendipine to diabetic rats for 8 weeks had a significant inhibitory effect on renal and glomerular hypertrophy, and showed a tendency towards a reduction in UAE (p = 0. 06) without affecting metabolic control or systemic blood pressure.
Albuminuria↗
Image quality in mammography with special reference to anti-scatter grids and the magnification technique.
Some of the parameters determining image quality in mammography are analyzed: the effects of primary photon spectra, focal spot size and screen-film systems on spatial resolution are discussed as are scattered radiation, development temperature and absorbed dose. The parameters limiting spatial resolution and contrast are evaluated for the standard and magnification techniques. Methods of reducing scattered radiation to improve contrast are evaluated. Scatter to primary ratios for different scatter reducing methods are compared, using the physical quantity energy imparted. For the standard technique the spatial resolution has been found to be limited by the fluorescent screen. With magnification technique the focal spot is the weakest link for the spatial resolution. The contrast is mainly set by the amount of scatter using the standard technique considering the use of a low tube potential (approximately 25 kVp). Using the magnification technique the amount of scatter is so small, that the tube potential is the limiting factor. We have found the optimized standard mammographic technique to be achieved under the following conditions: 25 kVp, 0.3 to 0.6 mm focal spot, film-focus distance 500 mm, anti-scatter grid, developing temperature 36 to 38 degrees C and 4 minutes total processing time with the screen-film system we have used. In magnification technique an air gap of at least 20 mm is desired. With an FFD of about 500 mm this will give a magnification ratio of 1.8 to 2.0 and a 0.1 mm X 0.1 mm focus spot is mandatory. With this technique, it is necessary to use a faster screen-film system than that used in standard mammography.
Female↗
Decreased sweating in growth hormone deficiency: does it play a role in thermoregulation?
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Adult↗
Long-term survival and quality of life in patients treated with a national all protocol 15-20 years earlier: IDM/HDM and late effects?
In a follow-up matched control study the 93 (70.5%) survivors of 132 children treated with a national protocol for acute lymphoblastic leukemia (ALL) and 5 survivors of the other 21 cases of ALL in childhood diagnosed in the same period were evaluated. Thus it was also a population-based study. The national treatment protocol was used in the period 1975-1980. Methotrexate (MTX) infusions combined with intrathecal MTX were used as prophylaxis against neuroleukemia instead of irradiation. Neither doxorubicin (Adriamycin) nor cyclophosphamide was used in the protocol. A questionnaire covering demographic data, number of offspring, learning problems, level of athletic performance, education, and work status as well as medical information was used. Forms were received from 94 (96%) of the 98 adult surviving cases and corresponding controls in the family. Interviews were performed in the remaining four cases (4%). There were no statistical differences between the two groups with respect to physical and mental health and quality of life. Hospital records of all patients were also checked for possible late effects. There was no definite case of secondary malignant neoplasm; however, there was one case of prolactinoma and only one case of serious sequelae (hemiparesis during therapy), probably due to intrathecal and intravenous MTX.
Adolescent↗
A new Salmonella surveillance and control programme in Danish pig herds and slaughterhouses.
The Danish Salmonella Surveillance and Control Programme for pigs operates at all stages of the production chain and has been applied nationally since 1995. Due to the program the level of Salmonella in Danish pork has declined from 3.5% in 1993 to 0.7% in the year 2000. Simultaneously, the number of human cases with salmonellosis due to pork has declined from approximately 1,144 in 1993 to 166 in 2000. In year 2001, the programme has been improved at a number of stages. A new classification scheme for the serological surveillance of finisher herds has been developed. The individual test cut-off in the mix-ELISA has been reduced to 20 OD%. Only herds producing more than 200 finishers/year are sampled. Based on the serological result from the last 3 months a new weighted salmonella index is calculated: The Danish Bacon and Meat Council has agreed on a new stricter penalty system. Level 2 and 3 herds get a penalty of 2% and 4% of the value per slaughter carcass, respectively. A new method of Salmonella testing on carcasses has been introduced; 5 carcasses per slaughter day are swabbed at 3 defined areas at 100 cm2 for each sample. This method is more sensitive than the one used previously. Herds infected with multiresistant Salmonella Typhimurium DT104 have to follow special restrictions. These include a requirement for a herd intervention plan, restriction on livestock trade, and a requirement for special slurry handling. Carcasses from DT 104 herds must be heat-treated or decontaminated with hot water.
Abattoirs↗
Effect of separate transport, lairage, and slaughter on occurrence of Salmonella typhimurium on slaughter carcasses.
The study aimed to reduce cross-contamination between finishers from Salmonella-positive and Salmonella-negative herds during transport, lairage, and slaughter, thereby reducing the prevalence of Salmonella Typhimurium on slaughter carcasses. In Phase 1 of the study, pigs from Salmonella-negative herds were kept in lairage for 2-4 hours either in clean pens (intervention group) or pens contaminated with Salmonella-infected faeces (control group). All pigs were slaughtered on the same slaughterline, and carcass swabs 24 hours after slaughter revealed a low degree of cross-contamination in the pens: there was no difference in Salmonella-positive carcasses between intervention (1.7%) and control groups (0.8%). In Phase 2, control pigs from Salmonella-negative herds were mixed with pigs from Salmonella-positive herds during lairage for 2-4 hours, while the intervention group still consisted of pigs from Salmonella-negative herds. All pigs were slaughtered on the same line: first intervention, then control. Carcass swabs taken 24 hours after slaughter failed to show a reduction in Salmonella-positive carcasses in the intervention group (4.5%) compared with the originally Salmonella-negative pigs in the control group (3.6%). In pigs from Salmonella-positive herds the occurrence of Salmonella was substantially higher at 10.4%. When the results were corrected for 6 carcass samples found positive with S. Heidelberg on the same day, which was attributed to a transient hygiene failure, only 2.2% of the carcasses in the intervention group were Salmonella-positive. We conclude that even though cross-contamination occurs in the abattoir pens, its importance on the slaughter line may be greater. However, the final results of this study should be awaited to conclude whether separate slaughter of pigs from Salmonella-positive and Salmonella-negative herds should be recommended.
Abattoirs↗
Assessment of the human risk associated with use of pork with possible presence of Salmonella typhimurium DT104 for dry-cured sausages.
We examined whether pork with suspected content of Salmonella Typhimurium DT104 (DT104) could be used for production of dry-cured sausages without jeopardizing consumer safety. The results of the risk assessment showed, that if Salmonella is present in raw pork, it is usually in low numbers. Additionally, during processing, an eventual presence of Salmonella will be reduced with at least two log units. The simulations showed that only 1-2 DT104 would be present in dry-cured sausages made by Danish pork, and this extremely seldom. Likewise, up to 4 DT104 would be present in dry-cured sausages made by foreign pork. It is not clear whether these low numbers of DT104 are capable of producing disease at all. However, if higher numbers are present, disease might occur. Therefore, we set up a monitoring and managing program, including a list with demands to processing in order to achieve minimum two-log reduction of any DT104 bacteria. The suggested scheme implies a far better and more systematic monitoring than the current system, ensuring the consumer a higher degree of food safety.
Animals↗
The development and implementation of standards of care in a breast cancer screening program.
The development and implementation of process, structure, and outcome standards were an integral part of program development for a mobile mammography screening program that provides service for the economically disadvantaged through the collaborative effort of eight primary healthcare centers, the Dade County Health Department, and the University of Miami/Jackson Memorial Hospital. The standards are used to guide and evaluate the screening program's operation and to provide the framework for additional program components (e.g., developing performance appraisals and quality assurance and risk management programs, establishing policies and procedures, and serving as the foundation for education and research projects). Examples of standards are provided to assist others in developing a systematic and ongoing evaluation plan for mobile mammography screening.
Breast Neoplasms↗
The role of non-thermal factors in the control of skin blood flow during exercise.
Arguments in favor of the importance of non-thermal factors in the control of skin circulation are presented. Such factors include exercise, posture, water and electrolyte balance, state of training, and acclimatization. The first three factors probably elicit their effects via high- and low-pressure baroreceptors, while the mechanisms involved for the remainder are unknown.
Cardiovascular Physiological Phenomena↗
A cancer nursing assessment tool.
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Female↗
Relationship between plasma volume reduction and plasma electrolyte changes after prolonged bicycle exercise, passive heating and diuretic dehydration.
Plasma volume was decreased by prolonged bicycle exercise, by passive heating in warm water, by sauna dehydration, and by diuretically induced dehydration in eleven well trained subjects. Blood samples from an arm vein were taken before and after this pre-treatment, as well as after a subsequent standard exercise test (SET) on a bicycle ergometer (50%, 70% and 105% of max VO2; the SET with no pre-treatment was used as a control condition. The changes in plasma concentration of Na+, K+ and Cl- were not proportional to the calculated plasma volume changes. The Na+ and Cl- concentrations always increased in the plasma, while plasma potassium concentration was increased after prolonged exercise, but decreased after the other types of dehydrations. The standard exercise test produced a pronounced fall in total calculated plasma potassium and in K+ concentration measured 3-5 min after exercise in all types of experiments. In the standard exercise test the calculated water loss from the plasma volume was relatively large. It amounted to about 2/3 of the total water loss in the standard exercise test and was independent of the pre-treatments.
Blood Volume↗
Rehabilitation of haemodialysis and transplant patients in denmark.
An evaluation of the extent of rehabilitation of 159 haemodialysis patients and 36 transplant patients from 6 of the 9 Danish nephrological centers was carried out. Half of the patients experienced their working capacity to be severely reduced prior to treatment and the percentage did not change during treatment. At the time of interview 88 percent of the patients received full disablement support and only ten per cent had retained their previous vocational position.
Age Factors↗
Reproducibility of the acute rejection diagnosis in human cardiac allografts. The Stanford Classification and the International Grading System.
Transplantation has become an accepted treatment of many cardiac end-stage diseases. Acute cellular rejection accounts for 15% to 20% of all graft failures. The first grading system of acute cellular rejection, the Stanford Classification, was introduced in 1979, and since then many other grading systems have evolved. Most recently, the International Grading System was introduced in The Journal of Heart and Lung Transplantation. In this study the interobserver reproducibility of both the Stanford Classification and the International Grading System is evaluated using Kappa statistics. Three observers evaluated 168 endomyocardial biopsy specimens according to the Stanford Classification and 100 endomyocardial biopsy specimens according to the International Grading System. The evaluation was carried out blindly. Kappa values of 54.1% and 51.5%, respectively, were obtained, both significantly above zero but not optimal. In addition to the interobserver reproducibility analysis of the two grading systems, the International Grading System is discussed. In the original description of the grading system terms such as focal, multifocal, and aggressive infiltrates and myocyte damage and myocyte necrosis are used. These terms create some difficulties in understanding or interpreting the various grades. The main problem is to distinguish between grade 1A and grade 3A. Despite the difficulties, the grading system is easy to use, but a revision is needed.
Biopsy↗
Electromyographic findings in amyloid polyneuropathy.
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Aged↗
Effect of lanreotide on local kidney IGF-I and renal growth in experimental diabetes in the rat.
Initial diabetic renal hypertrophy is preceded by a transient increase in kidney insulin-like growth factor I(IGF-I). In the present study streptozotocin-diabetic rats were treated with a new somatostatin analogue (lanreotide), insulin or placebo for 7 days and compared to non-diabetic control rats. Kidney IGF-I changes were examined in the renal cortex, medulla, and whole kidney homogenates. The renal cortex contained approximately 5.5 times more IGF-I than the renal medulla (p < 0.01); further, IGF-I increased transiently and more pronouncedly in the renal cortex compared to the medulla. Lanreotide treatment significantly inhibited diabetic renal and glomerular growth compared to placebo-treated diabetic rats. Further, lanreotide treatment was followed by a significantly lower medulla IGF-I by day 2, while lanreotide had no effect on cortex IGF-I accumulation. In conclusion, IGF-I accumulated transiently and was more pronounced in the real cortex compared to the renal medulla and, further, lanreotide prevented diabetic renal and glomerular growth bringing new evidence that intervention with somatostatin analogues may have a role in the prevention of experimental diabetic kidney disease.
Animals↗