[Immunodiagnosis of gastrointestinal tumors with the leukocyte adherence inhibition test].
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Biomedical subjects
Publications and source records attributed to B Neumeister.
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A case of osteomyelitis of the sternum due to Brevibacterium sp. in a neonate following mastitis of the mammary gland 20 days previously is described. The disease was successfully treated with cefazolin and oxacillin. The results of microbiological examinations and their significance are discussed.
Antibiotic susceptibility of 171 isolates of coagulase-negative staphylococci from 66 preterm infants at a neonatal intensive care unit was tested by the microbroth dilution method. Results were interpreted according to DIN as well as according to NCCLS. Because of the bimodal distribution of MIC values within the CNS population tested, results of susceptibility interpretation according to DIN were identical to NCCLS with the exception of netilmicin (NCCLS: 89% susceptibility; DIN: 16% susceptibility). Since netilmicin is frequently used for treatment of infections caused by coagulase-negative staphylococci, this difference may be of clinical significance.
Fusarium oxysporum was isolated twice from the blood culture of a 5-year-old boy with inoperable Wilms' tumour (stage IV) 4 weeks after a cytoreductive therapy with actinomycin D, vincristine and adriamycin. The child died 3 weeks after the first isolation of the fungus with signs of hepatic failure and consumptive coagulopathy. The importance of infection with Fusarium spp. in immunocompromised neutropenic patients and their pathogenetic role are discussed in the view of the literature.
We describe a case of fungaemia due to Candida pelliculosa (teleomorph: Hansenula anomala) in an otherwise non-immunocompromised patient with acute necrotizing pancreatitis of unknown origin. This species of Candida should be added to the list of pathogenic fungi which are increasingly important not only in patients with underlying immunosuppressive disease but also in patients with, for instance, severe surgical illness.
Alternaria alternata and Aspergillus terreus were isolated from cutaneous nodules in a 5-year-old girl with agranulocytosis of unknown origin. Histopathological examination supported the diagnosis of an infection with two opportunistic moulds. Aspergillus terreus was also isolated from the secretions of the maxillary sinuses of the patient. In spite of antimycotic therapy, the child eventually died from respiratory failure.
Exophiala jeanselmei and Mycobacterium chelonae were isolated from cutaneous nodules in a 73-year-old man with mycetoma of the right lower leg. Further evaluation revealed CD4+ lymphocytopenia without evidence of HIV infection. Antibodies to HIV 1/2, p24 antigen and HIV 1/2 (PCR) and reverse transcriptase activity were not detectable. The patient was not a member of any HIV risk group. He had not previously undergone therapy or suffered from immunodeficiency. This case clearly demonstrates that infections with opportunistic moulds and/or atypical mycobacteria should be taken into consideration not only in patients with classical immundeficiency diseases but also in apparently healthy patients because infection with these agents can be the first sign of underlying immunodeficiency.