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Biomedical subjects

B Naylor

Publications and source records attributed to B Naylor.

66 records · Page 4Linked to original sources
PubMedDate not supplied

Adenoma of the nipple. Cytopathologic features.

The cytologic appearances of two examples of adenoma of the nipple are described. The cellular samples from both lesions contained large numbers of epithelial cells, which were present both singly and in numerous clusters. The uniform nuclei contained finely distributed chromatin and inconspicuous nucleoli. Some of the cells varied in size and shape; a few had hyperchromatic nuclei. Small amounts of cellular debris, inflammatory cells and hemosiderophages were also present. Adenoma of the nipple can usually be distinguished cytologically from other lesions that may involve the nipple, such as Paget's disease, adenocarcinoma, fibrocystic disease, mammary duct ectasia, intraductal papilloma and chronic subareolar abscess; the cellular features of fibroadenoma, however, overlap those of adenoma and may cause diagnostic confusion. The increasing use of cellular samples obtained from breast lesions underscores the importance of recognizing this uncommon neoplasm and its cytologic manifestations. Adenoma of the nipple can be treated successfully by limited resection, and preoperative recognition will obviate unnecessary extensive surgery.

Adenoma↗
PubMedDate not supplied

Megakaryocytes in a hemorrhagic pleural effusion caused by anticoagulant overdose.

Sudden widespread hemorrhage, including a hemorrhagic pleural effusion, developed in a patient due to an overdose of anticoagulant. The pleural fluid contained megakaryocytes. Necropsy did not reveal myeloid metaplasia or any myeloproliferative disorder. Since megakaryocytes are normally found in pulmonary parenchyma, their presence in the pleural fluid was attributed to the hemorrhagic condition of the lung, which enabled megakaryocyte-containing blood to enter the pleural cavity.

Carcinoma, Small Cell↗
PubMedDate not supplied

Fine needle aspiration cytology of sarcomas metastatic to the lung.

A review was made of the morphologic features of cells aspirated from 17 sarcomas (5 malignant fibrous histiocytomas, 3 fibrosarcomas, 3 leiomyosarcomas, 3 endometrial stromal sarcomas, 1 osteosarcoma and 2 poorly differentiated sarcomas) metastatic to the lung, paying particular attention to the morphologic differences between the cells of sarcoma and carcinoma and between the cells of the different types of sarcoma. In general, sarcomas were characterized by loosely cohesive, rather flat, cellular aggregates and isolated cells. Three-dimensional cell balls or clusters were not present in any case. Cellular pleomorphism was a common, though not invariable, feature. Each type of sarcoma showed some morphologic distinctiveness; however, certain morphologic features were common to more than one type of sarcoma. By comparing the cytologic features of metastatic sarcomas in aspirates with the histologic features of the primary neoplasms, it should usually be possible to decide if a pulmonary lesion is a metastatic sarcoma.

Biopsy, Needle↗
PubMedDate not supplied

Pulmonary Hodgkin's disease. Diagnosis by fine needle aspiration.

The cytologic manifestations of pulmonary Hodgkin's disease in transthoracic fine needle aspirates from 13 patients with pulmonary radiologic abnormalities and a previous diagnosis of Hodgkin's disease are described. Classic Reed-Sternberg cells and lacunar cells were present in most cases. The so-called "mononuclear" Reed-Sternberg cells were identified in all cases. A cellular background consisting of variable numbers of histiocytes, eosinophilic and neutrophilic leukocytes and lymphocytes was frequently present. Such a background should stimulate a search for cells diagnostic of Hodgkin's disease. We conclude that the cytologic features of Hodgkin's disease are not only characteristic, but are also diagnostic, in patients with a prior history of Hodgkin's disease in whom pulmonary recurrence is suspected.

Adolescent↗
PubMedDate not supplied

Curschmann's spirals in cervicovaginal smears. Prevalence, morphology, significance and origin.

A retrospective examination of 172,119 cervical and vaginal smears was undertaken to study the prevalence, morphology, significance and origin of Curschmann's spirals in such specimens. Spirals morphologically identical to those seen in sputum were found in 101 specimens from 100 patients, for a prevalence of 1 in 1,704 smears. Spirals were found only in patients who had not had their cervices removed. The presence of the spirals could not be correlated with any particular gynecologic or nongynecologic abnormality. Most of the patients had no gynecologic abnormality. The literature contains suggestions that Curschmann's spirals in cervicovaginal smears are a manifestation of orogenital sexual contact or are formed in endocervical mucus, particularly in cigarette smokers. To investigate whether such spirals have an extraneous origin, we examined the smears for dust-containing histiocytes, vegetable cells, skeletal muscle fibers and other extraneous material, none of which was found. We found no correlation between the presence of spirals and cigarette smoking. Moreover, histologic sections of the uterine cervices from some of the patients who had spirals in their smears showed evidence of spiral formation in endocervical mucus. We conclude that Curschmann's spirals in cervicovaginal smears are an uncommon finding with no clinical significance, that they are formed from endocervical mucus and that their presence has nothing to do with orogenital sexual contact or cigarette smoking.

Adolescent↗
PubMedDate not supplied

Cytopathology, including transmission and scanning electron microscopy, of pleomorphic liposarcomas in pleural fluids.

Liposarcoma cells in pleural fluid from two patients with metastatic pleomorphic liposarcoma are described. The major diagnostic feature of such specimens, perceivable by light microscopy, is the presence of solitary, pleomorphic giant cells with cytoplasmic vacuoles. In some cells, transmission electron microscopy revealed numerous cytoplasmic lipidic droplets. With scanning electron microscopy, the cellular surfaces were markedly pleomorphic, with ruffles, blebs and long, thin processes.

Adult↗