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Biomedical subjects

B Naylor

Publications and source records attributed to B Naylor.

At least 37 records · Page 2Linked to original sources
PubMed1986

Pneumocystis carinii pneumonia. Cytologic manifestations and rapid diagnosis in routinely prepared Papanicolaou-stained preparations.

In this study of 28 immunocompromised patients, it was found that Pneumocystis carinii pneumonia could be easily and reliably diagnosed by examination of routinely prepared, Papanicolaou-stained cellular samples obtained by bronchoalveolar lavage, bronchial brushing, and bronchial washing. The distinctive intra-alveolar exudate of pneumocystosis observed in lung biopsy specimens was readily discernible in all of the cellular samples that demonstrated P. carinii by special stains. The exudate was not present in any of the P. carinii-negative samples. Routinely prepared, Papanicolaou-stained cellular samples can be relied upon for the rapid diagnosis of P. carinii pneumonia.

Bronchi↗
PubMed1984

Coexistent squamous cell carcinoma and adenocarcinoma of the uterine cervix.

The clinical and pathological features of 20 patients with coexistent squamous cell carcinoma and adenocarcinoma of the uterine cervix have been analyzed. Various combinations of in situ and invasive carcinomas were found. Located adjacent to each other and at times intermingling, these lesions probably originated from the subcolumnar reserve cells of the transformation zone. They are early lesions and may be precursors of adenosquamous and mucoepidermoid carcinomas of the cervix. The diagnosis of these double carcinomas depends upon being aware that the two entities may coexist in the same cervix. Treatment is conventional, and the prognosis is not worsened by the presence of the two types of neoplasms.

Adenocarcinoma↗
PubMed1983

Fine needle aspiration of para-aortic and pelvic lymph nodes showing lymphangiographic abnormalities.

Fifty-six fine needle aspirations of lymphangiographically abnormal pelvic and para-aortic lymph nodes were performed in 50 patients at The University of Michigan between January 1, 1977, and May 31, 1980. Fine needle aspiration was used both in the initial evaluation of patients with gynecologic malignancies and in the investigation of persistent and recurrent malignant disease. The overall diagnostic accuracy of fine needle aspiration was 74.0%. Fine needle aspiration yielded diagnostic cytologic specimens; it was safe and well tolerated, and in some instances it permitted the diagnosis of lymph node metastasis without laparotomy.

Biopsy, Needle↗
PubMed1982

Multiple primary neoplasms of the ovary and uterus.

Multiple primary neoplasms arising in the ovary and uterus were analyzed in 55 patients: 49 synchronous and 6, metachronous. When they occurred synchronously, 74.5% of the ovarian carcinomas and 93.6% of the uterine carcinomas were stage I lesions. The endometrial carcinomas were invariably well differentiated and superficial. It was the stage of the ovarian carcinomas that determined the prognosis of these patients. Ways of their identification as separate neoplasms are discussed. The potential to develop further neoplasms in the gastrointestinal tract and breasts should be borne in mind.

Adenocarcinoma↗
PubMed1981

Transthoracic needle aspiration biopsy: accuracy of cytologic typing of malignant neoplasms.

A correlation was made between the cytologic and the histologic diagnoses of 162 patients who underwent transthoracic fine-needle aspiration biopsy in whom histologic proof of the nature of the aspirated lesion was available. Compared to the histologic diagnosis, the specific cell-type cytologic diagnosis was usually in agreement when reported as squamous cell carcinoma (86%), adenocarcinoma (86%), or small cell anaplastic carcinoma(86%). In patients with a known extrapulmonary primary malignant neoplasm, the cytologic specimen was extremely helpful in identifying a new pulmonary lesion as metastatic rather than as a primary lesion in the lung. These results warrant the more extensive use of fine-needle aspiration biopsy in patients with pulmonary neoplasms in whom the specific cell type of the malignant neoplasm has important implications in therapy.

Adenocarcinoma↗
PubMed1980

Megakaryocytes in pleural and peritoneal fluids: prevalence, significance, morphology, and cytohistological correlation.

Over a period of 22 years, 4844 pleural and peritoneal fluids from 3279 patients were examined cytologically. Megakaryocytes were found in the fluids from five patients. The clinical diagnoses in the five patients were agnogenic myeloid metaplasia, chronic myeloid leukaemia, and lymphocytic lymphoma. All of these patients had persistent serous effusions. Megakaryocytes in serous fluids occurred in three forms: (1) a large type with abundant cytoplasm and multilobed nuclei, (2) a smaller type with a high nucleocytoplasmic ratio and unlobed nuclei, and (3) anucleate cytoplasmic masses. Foci of agnogenic myeloid metaplasia found on the serous surfaces at necropsy of two patients contained megakaryocytes similar to those in the corresponding effusions. The clinical course of our patients confirmed that the presence of megakaryocytes in serous fluids signifies an advanced haematopoietic malignancy.

Aged↗
PubMed1980

Idiopathic pulmonary hypertension associated with nodular pulmonary infiltrates and portal venous thrombosis.

A case of idiopathic pulmonary hypertension is associated with portal venous thrombosis. The patient's chest roentgenogram revealed numerous nodular densities which at necropsy were found to have been caused by an exuberant fibroblastic reaction around small pulmonary arterioles. This is an example of the unusual association of idiopathic pulmonary hypertension and portal venous thrombosis, and to our knowledge, the first report of roentgenographically visible pulmonary nodules secondary to the pathologic alterations of idiopathic pulmonary hypertension.

Adolescent↗
PubMed1977

Production of prostaglandins by the pseudopregnant rat uterus, in vitro, and the effect of tamoxifen with the identification of 6-keto-prostaglandin F1alpha as a major product.

1 Prostaglandin production by rat uterus homogenates has been studied, in vitro, on days 2 to 13 of pseudopregnancy. 2 The highest production of prostaglandins occurred on day 5. 3 The amounts of prostaglandins F and D formed were higher than the amounts of prostaglandin E on every day studied. 4 The ratios of prostglandins F and D to prostaglandin E produced steadily decreased up to day 6. It then increased with the highest values occurring between days 10 and 13, 5 Progesterone levels in peripheral plasma increased rapidly from days 2 to 5, remained high up to day 9, then steadily decreased between days 10 and 13. 6 The anti-oestrogenic drug, tamoxifen administered on day 2, significantly inhibited the increase of prostaglandin production which occurred on day 5. Prostaglandin E production was inhibited more than the production of prostaglandins F and D. 7 Analysis of the uterine extracts by gas chromatography and mass spectrometry showed prostaglandin F2alpha, F1alpha (in trace amounts), E2 and D2 to be present. 8 The major product detected was 6-keto-prostaglandin F1alpha. Its identification forms an addendum to the paper. 9 Also present as a major product was 6(9)-oxy-11,15-dihydroxyprosta-7,13-dienoic acid.

Animals↗
PubMed1977

Pulmonary phycomycetoma in a patient with diabetes mellitus.

Phycomycetes are ubiquitous saprophytic fungi sharing with other fungi a propensity for invasion and disease production in immunologically compromised hosts. Diabetes mellitus, in particular diabetic ketoacidosis, is a common clinical setting for phycomycosis. A pulmonary phycomycetoma was diagnosed in a diabetic patient from material obtained by bronchial brushing was treated successfully with a combination of surgery and amphotericin B.

Diabetes Complications↗
PubMed1975

Effects of oestradiol and progesterone on the in vitro production of prostaglandin F2alpha by the guinea-pig uterus.

1 The effects of oestradiol and progesterone on the production of F 2alpha by the guinea-pig uterus in vitro have been studied. 2 Ovariectomized guinea-pigs were treated with oestradiol benzoate, progesterone, or a combination of these hormones. The uteri were homogenized and incubated and the prostaglandin F2alpha produced was measured by radiommunoassay or combined gas chromatography-mass spectrometry (g.c.-m.s.). Oestradiol treatment or progesterone followed by oestradiol caused a significant increase in prostaglandin F2alpha synthesis compared with control values, whereas progesterone treatment caused no significant increase. 3 The uteri from guinea-pigs on day 7 of the oestrous cycle were split into four parts, and each part homogenized and incubated either alone or in the presence of oestradiol-17beta, progesterone, or a combination of these hormones. Prostaglandin F2alpha was measured by g.c.-m.s. Oestradiol was found to increase prostaglandin F2alpha synthesis by the uterus whereas progesterone had no effect. However, progesterone did inhibit the response to oestradiol. 4 Oestradiol treatment of the guinea-pig uterus causes an increase in capacity to produce prostaglandin F2alpha in vitro. The role of progesterone is difficult to interpret.

Animals↗