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Biomedical subjects

B Nalbanski

Publications and source records attributed to B Nalbanski.

At least 73 records · Page 4Linked to original sources
PubMed1993

[Our clinical experience in treating endometriosis genitalis externa with the preparation Danoval].

By means of the serum level of estradiol and the vaginal smear indexes the antigonadotropic activity of the preparation Danoval (2-3-isoxasol-17-ethinyltestosterone) is indirectly evaluated on 15 infertility patients with laparoscopic proved endometriosis. After 5 month's course of treatment with 400 mg daily the level of estradiol decreased from 1.54 to 0.31 nmol/l, IA from 20.8 to 10.4 and IP from 32 to 17.3. The side effects are slight and descend from the pharmacological properties of the preparation. Two patients became pregnant in three months after the treatment.

Adnexal Diseases↗
PubMed1991

[Folliculometry as a method for determining ovulation in insemination with frozen sperm].

The authors carried out studies retrospectively on 57 women, who became pregnant in insemination with donor frozen spermatozoa. Ovulation problems and luteal insufficiency were diagnosed in advance and treated before and during the occurring cycles. Women were divided into two groups. The first group of 25 women were examined by ultrasound transvaginal transducer for follow-up of follicle growth in the ovaries in addition to measurement of body temperature and determination of the cervical factor. The second group of 32 women, in whom follicle-metry was not performed. The frequency of conception was 0.24 in the first group, but 0.26 in the second group. It is concluded that inspite of the significance of follicle-metry for determination of ovulation the traditional methods are still valid criteria for ovulation and can be used as independent methods for determination of the time for insemination with therapeutic donor frozen spermatozoa.

Female↗
PubMed1991

[A comparison of 2 diagnostic methods in women with long-term sterility].

The study was carried out on 40 women, admitted to the clinic for diagnostic laparoscopy. The mean age of the patients was 28.57 years. Duration of sterility was 5.7 years as 27 women suffered from primary sterility and 13 women-with secondary. Ultrasound diagnosis was made on all women before laparoscopy. The exactness of ultrasound diagnosis (USD) was 80.51% of women. Preovulatory follicles and polycystic disease of the ovaries was established by USD in 100% of women. High sensitivity of the method was achieved in women with leiomyomas and ovarian cysts. Discrepancy in the diagnosis was found in the following cases: a myoma was hyper-diagnosis, a hydrosalpinx was diagnosed as a cyst; a tubo-ovarian formation was found to be hydrosalpinx and vice versa; two hydrosalpinx women with diagnosed hydrosalpinx had tubo-ovarian formations. A hydrosalpinx was not diagnosed. USD was found to be almost non-valid in comparison of the two methods for diagnosis of endometriosis.

Adult↗
PubMed1990

[Oral contraceptive agents and antithrombin III].

Antithrombin III is one of the most important inhibitors of serine proteases of coagulation and fibrinolysis. It inhibits the activity of thrombin and factor X. Its congenital or acquired reduction leads to an increased risk of thrombosis. In their study the authors aimed to investigate the influence of oral contraceptive preparations--Gravistat and Nonovolan on the activity of antithrombin III. Thirty five women, receiving these drugs for a period of one month to ten years (on the average two and a half years were examined. All women received the drugs in accordance with the physician prescription, taking into consideration the lack of history data on increased frequency of thrombosis. Part of the examined group (the first ten on the table of the results) were smokers with mean usage of 15 cigarettes per day. The study was carried out on 25 women at the three stages of the hormonal cycle, but singly on the remaining 10 women in its beginning. Blood sample for examination was taken with anticoagulant (citrate) in the morning before breakfast and the activity of the inhibitor was determined by kinetic colorimetric method and chromatogenic Chromasin TN (a modification of Kamenov). The results were presented in percentages. The mean activity of antithrombin III was: means = 107.5%, which did not differ from the reference values. The activities at the three phases of the menstrual cycle did not differ significantly (p greater than 0.05). The results, obtained from the study, proved that hormonal contraceptive drugs did not reduce the activity of antithrombin III.

Adult↗
PubMed1990

[The ultrastructural changes occurring in the endometrium of women who use intrauterine pessaries].

The authors studied ultrastructural changes in the endometrium of 25 women, using intrauterine contraceptive devices, preventing conception, during various time limits. The material of the endometrial biopsy was fixed with glutar and osmium in a phosphate buffer and embedded in durcopan. Section were prepared by a microtome and observed under electron microscope of Hitachi type. Comparing the parameters duration of usage of loops and character of changes in the endometrium an impression was obtained that the usage of contraceptive intrauterine devices for one-year period did not induced changes of pathological character. Functional changes in the endometrium occurred after a two-year stay of the loop in the uterus as there were inflammatory changes of spot-like character in two of the sections. Local areas of inflammation of nonspecific character, manifested under the form of lymphocytes and leucocyte accumulation, were found in women with long usage of contraceptive intrauterine devices. The authors advise to remove the loop 2.5-3 years after its application and to wait for the complete regeneration of the endometrium.

Endometritis↗
PubMed1990

[The importance of laparoscopy in the diagnosis of tubal sterility].

Analyzing the findings in diagnostic laparoscopy the authors describe in details and interpret the results from the examined organs in the pelvis and abdominal cavity. Object of the study are 200 sterile women, admitted to the clinic of Sterility and Gynecological Endocrinology of Research Institute of Obstetrics and Gynecology for examination. The mean age of the patients is 29 years as 128 of the women suffer from primary sterility, but 72--from secondary sterility. The results are summarized and interpreted in 5 groups. Uterine body--form, size, motility, measurements, adhesions, fibrillary apparatus, patency; Ovaries--form, size, position, motility, surface, follicles; Adhesions--type, dimensions, vascularization, position (in the pelvis and abdominal cavity); Data for endometriosis--presence, size and localization of endometriomas, endometriotic cysts and outgrowths, an increased vascular line. The inference, which the authors make, is that laparoscopy is basic (and necessary) current diagnostic method for obtaining real notion for the state of internal genital organs (especially for tubal factor in female sterility) and furthermore also for evaluation of the necessity and possibility for performance of microsurgical reproductive operations.

Adult↗
PubMed1990

[Hysterographic follow-up of the results of treating uterine synechiae with an intrauterine contraceptive pessary].

The authors discuss the results from roentgenological (cervical hysterography) examination of the uterine cavity, aiming to confirm the results from the treatment of intrauterine synechiae. It was established that there were no roentgenological data for synechiae after the conducted treatment in 73.9% of the examined hysterograms. The treatment had no substantial effect only in 8.7% of women as synechiae remained unchanged. Very good results were obtained after usage of the intrauterine contraceptive devices--Super Dana and Lippes, possessing volumetric and stretching form in respect to the uterine cavity. The authors conclude that the hysterography is exact diagnostic method for confirming the effect of treatment of synechiae in the uterine cavity with suitable intrauterine loops.

Adult↗
PubMed1990

[The characteristics of the x-ray image of the uterus bicornis].

The results from a hysterographic study on women with bicornuate uterus are discussed. It is established that its frequency is 2.2% of 1623 performed hysterosalpingographies. A detailed analysis is made on the form and dimensions of the cornua [correction of corns], total isthmic part and cervical canal. Some metric parameters (height and width, sizes of the isthmus the an angle between the corns) are given with the purpose of greater precision of roentgenological interpretation.

Contrast Media↗
PubMed1990

[A report of 2 cases of the Herlyn-Werner-Wunderlich syndrome].

Two cases are described, illustrating two varieties of comparatively little known, but not rarely encountered syndrome--the syndrome of Herlyn-Werner-Wunderlich. The characteristic and the symptoms of the syndrome are presented and various concepts on therapeutic management are discussed. The question about future fertile capability of the patients is discussed as well.

Abnormalities, Multiple↗
PubMed1990

[The hysterosalpingographic characteristics of the changes in the uterine tubes after a wedge resection of the ovaries].

The authors analysed results from a hysterosalpingographic study on 58 women with primary sterility, on whom wedge resection of the ovaries was performed in the past. It was established that changes in the uterine tubes were found in more than 1/3 of the examined women and consisted mainly of periampullary adhesions as the two tubes were involved usually. On the basis of the obtained results an inference is made that the usage of resection of ovaries for treatment of some forms of female sterility should be applied only in cases, when conservative methods for treatment are completely inefficient.

Adult↗
PubMed1990

[A comparative study of the efficacy, tolerance and side effects in using IUDs--the Copper T and Nova T--over a 3-year period].

The author examined 153 women, using the intrauterine contraceptive device Copper T, and 120 women, using the intrauterine contraceptive device Nova T. 10.3% of all observed women are nonparous, the mean number of born children is 1.1% and the relative number of abortions is 2.9 in the group of parous women. The occurrence of side effects are registered by dispensary observation twice during the first year and once during the following period. The degree of conception in both groups is low below the accepted ranges. The same is also referred for the monthly risk of expulsion of the loop. The intramenstrual inflammatory and painful parameters are increased 1.5-2.1 times in comparison with women, using the intrauterine device Nova T. Menstrual bleedings in both groups of women is prolonged with 1.3 days on the average. There are no pathological complications during the whole period of observation.

Abortion, Spontaneous↗
PubMed1989

[Oral contraceptive agents and the fibrinolytic system].

The study included 35 women at the age of 20 to 38 years, using oral contraceptive drugs for a period of two to ten years. Changes in the activity of plasmin and alpha 2 antiplasmin were examined in the blood plasma. The study included three phases of the menstrual cycle (7-14-21 day) in 25 women. Kinetic methods with chromogenic substrates were used as Statchrom PLC was used for plasmin, but Chromosim AP (modification of Kamenov)--for alpha 2 antiplasmin. The applied contraceptive hormonal preparations were Gravistat 250 and Nonovlon. The mean activity of plasmin was x = 108.3%, but of alpha 2 antiplasmin x = 106.3%. Both values did not differ from that of the reference group (p greater than 0.05). The established slight tendency to a reduction in the activity of both examined parameters could be due to differences in the hormonal content of the preparations as well as to individual fluctuations of the hormonal cycle in the investigated patients. The two proteins participate in the acute reaction of the organism and change their concentrations quickly and this fact should be taken into consideration as well.

Adult↗
PubMed1989

[Ultrasonic follow-up of ovarian follicles in sterile women].

The authors examined 39 women with sterility varying in time. Their ovaries were follow-up during 68 menstrual cycles. Linear growth of the follicle, which detached the egg cell, was established. The size of the follicle varied between 15.4-21.4 mm during the separation of the egg cell. The follicles remained static in anovulation, after which they became regressive or formed follicular cyst with various measures.

Adult↗
PubMed1989

[The x-ray characteristics of the changes in the fallopian tubes of women with primary sterility who have had an appendectomy].

Using hysterosalpingography an attempt was made to classify the changes occurring in the uterine tubes of 114 women with primary sterility, undergone appendectomy in the past. It was established that changes in the tubes presented various character and included 2/5 of the material. There was direct dependence between appendectomy with complications and the gravity of the tubal factor.

Adult↗
PubMed1989

[Use of sinusoidal modulated currents with various parameters in treating tubal sterility].

Treatment with sinusoidal modulating currents, applied by two various methods, was used in 89 women with tubal sterility. An original method, proposed by the authors, was compared with known and most frequently used up to now method for treatment of chronic salpingo-oophoritis with sinusoidal modulating currents. In two groups of patients, treated by the method developed by the authors, conception was established in 20.7% and 32.43% against 8.7% of the patients, treated by a control method. The authors think that parameters of action due to sinusoidal modulating currents established by them, are more efficient and recommend the method, developed by them, to be used more widely in therapeutic practice by the consulting offices of sterility in our country.

Adult↗