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Biomedical subjects

B N Tandon

Publications and source records attributed to B N Tandon.

At least 127 records · Page 7Linked to original sources
PubMed1980

Liver specific autoimmunity and chronic liver disease--an enigmatic relationship.

Refinements in techniques for identifying liver specific immune responses have currently aroused considerable interest in the role of such immunity in the pathogenesis of chronic hepatic disorders. Presence of antibodies against liver cell membrane was tested for in 242 samples of serum and in 86 liver biopsies from patients with liver diseases as well as from controls. Indirect immunofluorescence tests on isolated rabbit hepatocytes and on human liver cells from biopsies respectively were carried out. In the serum, antibody was detected in 16 per cent, several of these cases belonging to the category of recovering acute viral hepatitis and some to chronic hepatitis or to other liver disorders. Serum HBsAg status in these antibody carriers vary. Antibodies on liver cell membrane were detected in approximately 25 per cent cases of hepatitis. The distribution among different cases were like in case of serum positivity. The pathogenetic role of these antibodies in initiation or progression of disease appears doubtful. It is possible that presence of these antibodies merely represents an immune response following liver injury and may not be responsible in causing acute or chronic liver disease.

Adolescent↗
PubMed1978

An unusual outbreak of hookworm disease in North India.

An unusual outbreak of hookworm disease occurred after a game of "kabaddi" (a local game which results in much body contact with the ground) in 27 young males from one village. It was characterized by an immediate incapacitating dermatitis, followed by severe pulmonary symptoms. Progressive weakness, abdominal pain, weight loss and anemia developed within a few months. Ancylostoma duodenale was found in all except four patients who had received antihelminthic treatment. Specific treatment for hookworm resulted in complete clinical recovery. Features of the outbreak were: 1) the hitherto unrecorded mode of infection; 2) severe dermatitis; 3) pulmonary symptoms lasting more than 3 mo; 4) abdominal symptoms suggestive of subacute obstruction starting 4-6 mo after exposure; and 5) severe disability with weight loss for a period of 1 yr until specific treatment was administered.

Adolescent↗
PubMed1978

Epidemic of toxic hepatitis in India of possible mycotoxic origin.

An epidemic of liver disease, characterized by onset with high fever, rapidly progressive jaundice, and ascites occurred in a rural area of India. Several hundred people were affected and mortality was high. The epidemic was heralded by the appearance of similar features in the village dogs. Liver biopsy specimens from eight cases and autopsy material from one human case and two dogs were studied. Characteristic features were centrizonal scarring, hepatic venous occlusion, ductular proliferation and cholestasis, focal syncytial giant-cell tr-nsformation of hepatocytes, and pericellular fibrosis. Toxic quantities of aflatoxin B1 were found in samples of corn, the staple food grain of the people, that was obtained from the domestic food stores. The etiology of the disease could not be unequivocally established, but aflatoxins, perhaps in combination with other factors, may have been the cause.

Aflatoxins↗
PubMed1978

An epidemic of veno-occlusive disease of the liver in Afghanistan. Pathologic features.

A large outbreak of veno-occlusive disease occurred in Afghanistan in which approximately 7,800 in a population of 35,000 subjects were estimated to have been affected. It was caused by consumption of wheat flour heavily contaminated with seeds of a plant of the heliotropium species. These were found to contain pyrrolizidine alkaloids, chiefly heliotrine. Fourteen percutaneous liver biopsies, representing different stages of diseases and liver tissue from eight autopsies were studied. Morphological changes in the liver were characteristic. Centrilobular hemorrhagic necrosis was followed by occlusive changes in the hepatic veins, finally resulting in nonportal cirrhosis. The sequence of changes observed suggests primary parenchymal injury and possibly obstructive lesions at the sinusoidal level. Collagenization of the sinusoids and reorganization of the lobular reticulin begin early in disease. Occlusive changes in the efferent veins apparently follow.

Afghanistan↗
PubMed1977

Effect of periodic deworming on nutritional status of ascaris-infested preschool children receiving supplementary food.

The weight for age of 154 undernourished preschool children in an ascaris-infested community receiving supplementary food was monitored for a year. 74 children were given tetramisole every 4 months, while 80 controls were given placebo. The prevalence of ascaris (roundworm) infection and the severity of protein-energy malnutrition were the same in the two groups at the onset of the study. Stool-positive rates for ascariasis came down significantly in the experimental group during the year, but eradication of the worm was not possible owing to constant re-exposure. Nutritional status remained unaltered in the controls but improved strikingly in the treated children 8 and 12 months after the start of the study. Periodic deworming should form a part of the supplementary feeding programme if malnutrition is associated with ascariasis in the community.

Ascariasis↗