Inter observer agreement in clinical diagnosis.
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Humans↗
Biomedical subjects
B N Reddy
Publications and source records attributed to B N Reddy.
A computerized information system for evaluation of NLEP through monthly progress reports.
A computerized system for monitoring district-wise operational performance and epidemiological progress using existing regular and special monthly reports of the National Leprosy Eradication Programme (NLEP) is presented. The same system, with some minor modifications could be used for programme assessment at the Leprosy Control Unit level also. The advantage of the system is the speed with which it can generate output in the form of comparative tables and graphs for different regions for use by programme managers for making overall assessments in time and for sending feedback reports to workers at various levels, for self-assessment and for taking timely corrective action. The system presented provides immediate and easy access to the stored and/or processed information (indicators etc.,) at any time. The system has been pilot-tested using monthly reports from eighteen districts of Tamil Nadu.
Databases, Factual↗
An epidemiological study of leprosy in a rural community of Pondicherry.
In a rural area, endemic for Leprosy a total population survey had been undertaken in 6 villages covering a population of 5667. Out of the 5281 persons examined, 191 were found to be suffering from leprosy giving a prevalence rate of 36.16/1000. The prevalence was highest in children aged between 5 and 14 years., i.e., 41.61/1000. Among adults the highest prevalence was seen among those aged above 45 years, i.e., 45.66/1000. Both the sexes were found to be equally affected in this area. Tuberculoid leprosy was the most common type found with a prevalence rate of 23.29/1000, followed by Indeterminate type with a prevalence rate of 5.3/1000. Lepromatous rate was 3.69%. The disability rate was found to be 16.23%, with a mean disability index of 0.927.
Adolescent↗
Role of Dapsone in chemotherapy of leprosy--a comparison of responses to therapy in two cohorts in 1960s and 1970s.
Two cohorts of bacterio-positive cases registered and started on treatment during 1960-62 and 1968-70 were studied for differences in their response to DDS monotherapy. Proportion of male and female cases, mean Bacteriological Index (B.I.) and the distribution of cases according to the initial BI did not differ between the two cohorts. 49.7% of the patients in the II cohort were taking regular treatment against 27.4% in the I cohort. At the end of 7 years of treatment, proportion of the cases that were bacteriologically negative were 68.6% and 83.0% in I and II cohorts respectively. Relapse rates in I and II cohorts were 14.3% and 7.9% respectively, over a period of 7 years. The findings showed that Dapsone continued to be an effective antileprosy drug and must be included in all multidrug regimens in the therapy of leprosy.
Adolescent↗
An epidemiological study of leprosy disability in a leprosy endemic rural population of Pondicherry (south India).
The disability rate in this study was 16.23%. The highest disability rate of 30.76% was found in those aged 45 years and above. Disabilities were found to be more common among male leprosy patients with a disability rate of 21.05% compared to that of 11.45% found among female leprosy patients. None of the indeterminate leprosy patients showed any disabilities, whereas all the neuritic and lepromatous leprosy cases showed disabilities. The disability rate among tuberculoid leprosy patients and borderline leprosy patients were found to be 3.25% and 35% respectively. Persons whose monthly per capita income was less than Rs. 200/- constituted 93.50% of the cases with disabilities. Anaesthesia of the hand was seen in 67.4% of the cases. The mean disability index (DI-2 type) was 0.927.
Adolescent↗
Non acid-fast fluorescent M. leprae (?) in skin smears from leprosy patients.
Smears from 74 known smear negative cases of leprosy were examined after staining with Auramine 'O'. 40.54% cases were positive for fluorescent bacilli. 60.52% of cases on treatment and 19.44% cases after RFT had fluorescent bacilli in the skin smears. Results suggest the possibility of a non acid-fast fluorescent positive variant of M. leprae.
Benzophenoneidum↗
Cellularity of macrophage granuloma and morphological index.
In the present study, morphological index (MI) and average macrophage count per microscopic field in skin sections of 94 lepromatous (LL) patients is correlated. The subjects included 14 cases with some histoid features. The MI in the lepromatous cases varied from less than one to 40 and the corresponding macrophage counts ranged from 40 to 156. In cases with histoid changes the MI varied from 30 to 60 and the cell count ranged from 215 to 360. The histoid cases showed a higher MI and cell count compared to the other lepromatous cases. There was a positive correlation between MI and macrophage count and the hypercellular state appears to depend on living and multiplying bacteria.
Cell Count↗