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Biomedical subjects

B Modell

Publications and source records attributed to B Modell.

100 records · Page 6Linked to original sources
PubMed1980

Obstetric aspects of midtrimester fetal blood sampling by needling or fetoscopy.

We describe our experience at University College Hospital, London, with the first 135 patients submitted to midtrimester fetal blood sampling for antenatal diagnosis of beta-thalassaemia major, other thalassaemias and homozygous sickle cell disease. Blind needling and fetoscopy with sampling are evaluated and their application discussed. With experienced operators 9 per cent of patients experienced a fetal loss.

Anemia, Sickle Cell↗
PubMed1979

Antenatal search for fetal beta-thalassaemia in a twin pregnancy.

The antenatal search for fetal beta-thalassaemia in a twin pregnancy is described. Thalassaemia major was correctly excluded in both fetuses, and some of the problems of identifying patients at risk are outlined as well as those of obtaining fetal blood in the second trimester of pregnancy.

Adult↗
PubMed1978

Antenatal diagnosis of thalassaemia major.

Haemoglobin synthesis was studied in fetal blood samples obtained at 17 to 20 weeks' gestation in 22 women at risk of carrying a fetus with homozygous beta-thalassaemia. A presumptive diagnosis of homozygous beta-thalassaemia was made in four cases, and the pregnancy was terminated. An inconclusive answer was obtained in one case, and the patient also chose to have her pregnancy terminated. Two fetuses were lost as a result of the procedure. Of the remaining 15 pregnancies, 13 proceeded to term and two to 36 weeks; in each case a normal infant or one heterozygous for beta-thalassaemia was delivered. Current efforts should be directed towards improving the blood sampling technology so that fetal blood sampling can be used widely in those countries where thalassaemia is a major problem.

Abortion, Eugenic↗
PubMed1976

Presence of gene for beta globin in homozygous beta0 thalassaemia.

In one southern Italian and one Pakistani patient with homozygous beta0 thalassaemia in which no detectable beta-globin synthesis occurs and no beta-globin messenger RNA is found, the gene for beta globin has been shown to be present using complementary DNA. This demonstrates that for these patients the imbalance in chain synthesis is not attributable to a gene deletion.

DNA↗
PubMedDate not supplied

Consanguinity and reproductive behaviour in a tribal population 'the Baiga' in Madhya Pradesh, India.

We have studied the marriage pattern and reproductive behaviour in a single Central Indian primitive tribe, the Baiga. Parents were consanguineous in 34% of marriages (19.2% mother's brother's daughter (MBD), 13.1% father's sister's daughter (FSD) and 1.7% were double first cross-cousins (DFCC). Fertility levels were significantly higher (p < 0.05) in related couples (4.7 offspring/couple) than unrelated couples (4.2/couple). Mortality (up to 20 years) was 19%. In the offspring of consanguineous couples it was higher (19.7%) than in the offspring of unrelated couples (18.6%) but the difference was not statistically significant. In consanguineous couples the reproductive period was longer than in unrelated couples, probably to allow compensation for increased reproductive losses (infant and childhood deaths). The level of social as compared to genetic parenting was about 35% as measured by tracking the inheritance of sickle gene, and allowance must be made for this in assessing the influence of consanguineous marriage on fertility and mortality.

Adolescent↗