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Biomedical subjects

B Migdalska

Publications and source records attributed to B Migdalska.

88 records · Page 5Linked to original sources
PubMedDate not supplied

[Multiple adenoma of the adrenal cortex with the clinical picture of Cushing's syndrome].

The paper sums up the experience of the clinic in diagnosing and therapy of the Cushing syndrome due to multiple autonomous adrenal cortical adenomas. The observation was carried out in a group of 5 women between 15-44 years of age (31.7 on an average). In the clinical material including 225 cases of the Cushing syndrome, they amounted to 2.2 per cent. All the five patients had typical somatic symptoms, myasthenia, ++amenorrhea. In hormonal examinations the content of 17-OHCS in the 24-hour urine was only periodically increased, 17-KS was within the normal range. There was no inhibiting action of dexamethasone on the excretion of cortisol, even when the initial values of corticosteroids++ were normal. The concentration of ACTH in the blood (determined in 3 cases) was around low normal range. Three patients underwent computer tomography; in one case adrenal glands were of normal size, in the second case--the two glands were enlarged, in the third case--the right gland was much larger than the left one. Microscopic examinations showed the atrophy of adrenal cortex beyond the adenomas. In case of multiple adenomas of the left gland surgery was confined to unilateral adrenalectomy. Among the remaining 4 patients, 3 underwent simultaneous resection of the two glands. All the patients showed the regression of symptoms of the disease, except for the changes in bones. One patient did not turn up for further therapy after unilateral adrenalectomy because of partial improvement.

Adenoma↗
PubMedDate not supplied

[Study of the interdependence between prostatic hypertrophy and disorders in hormone levels. Preliminary report. 1. Study of blood testosterone].

Using the radioimmunological method and applying the double antibody separation technique, testosterone was determined in 14 patients and LH in a few. A group of men in good health aged between 20 and 60 years (22 persons) was used as a control and a group of men aged from 60 to 90 years (24 persons) in whom the size of the prostate gland corresponded to their age. In 4 patients, testosterone levels were determined before and after prostatectomy. It was found that testosterone levels in the serum of men aged over 60, in good health, were markedly lower. Patients with prostatic hypertrophy showed testosterone concentrations several times higher than the men in the control groups. Testosterone levels in patients with considerable hypertrophy of the prostate were higher than in patients with moderate hypertrophy. Adenomectomy had a remarkable influence on the decrease of testosterone in the serum.

Adult↗
PubMedDate not supplied

[Surgical treatment of acromegaly by the trans-sphenoidal approach. II. Hormonal results].

Growth hormone determinations were done in the serum of 45 patients with acromegaly. In 3 cases the basal GH levels was normal, in the remaining ones it was raised. Of the functional tests those with insulin, glucose and L-Dopa were done. The tests with glucose and L-Dopa loading were found to be more useful diagnostically than the insulin test. After surgical treatment the GH level returned to its normal value in 10 cases, but in most cases it fell to at least one half of the initial value. In 5 cases with more pronounced expansion of the pituitary tumour the GH value was not significantly changed.

Acromegaly↗