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Biomedical subjects

B Melsen

Publications and source records attributed to B Melsen.

At least 73 records · Page 4Linked to original sources

Force system developed from closed coil springs.

The present paper provides data on load-deflection rate and maximal force generated for 19 coil springs. The force level at activation and deactivation was registered at intervals of 5 mm between 0 and 100 per cent extension. Ten springs of each type were analysed. The following questions were answered. How many of the springs exhibited the behaviour of a superelastic spring and how many types of springs differed significantly from each other with respect to force deflection rate and maximal force level at 100 per cent extension? Of the products tested only the springs from GAC exhibited the behaviour characteristic of the superelastic wire. The 19 products could, from a clinical point of view, be classified into four different groups with regard to force deflection rate and five groups with regard to maximal force. The variation within each product also differed between the products with the lowest intra-product variation seen in the TP springs. In light of the present findings it is obvious that manufacturers' information was not satisfactory. The need for more thorough user information is stressed.

Elasticity↗

Dentin formation in miniature pigs with special reference to indomethacin and orthodontic treatment.

The rate of dentin mineralization and the influence of indomethacin on the dentin mineralization rate during orthodontic treatment was determined in miniature pigs by intravital labeling with tetracycline. The results demonstrated that the dentin mineralization rate in the control animals was 3.8 microns/day, a rate corresponding to that of human teeth. Both indomethacin and orthodontics had an effect on the dentin mineralization rate, indomethacin reducing and orthodontic forces increasing it. In combination, the two factors neutralized each other.

Animals↗

Craniomandibular dysfunction following surgical correction of mandibular prognathism.

Craniomandibular function was studied in 36 adult patients in whom mandibular prognathism was corrected with a combination of surgical (vertical ramus osteotomy) and orthodontic procedures. Each patient was examined up to 1 week before surgery and again 6 months later. Mandibular mobility, impaired function of the temporomandibular joint, and pain in the masticatory muscles and temporomandibular joint were evaluated. Data were classified according to a numerical scale and patients were divided into three groups: symptom free, mild symptoms and severe symptoms. Although there was no difference in the overall frequency of the three functional groups during the two phases of examination, 20 patients showed a change in functional status following surgery. Before surgery, decreased mandibular mobility was found in 19 patients; after surgery, four additional patients were included in this group. Temporomandibular joint function improved in 10 patients and three patients had less pain. The frequency of muscle pain did not change. Postoperative maximal interincisal opening was reduced by 5.4 mm (p less than 0.001) but lateral excursive movements did not change significantly. No significant relationships were found between pre- and postoperative mandibular mobility, temporomandibular joint function and muscle pain. Females experienced mild or severe dysfunction more often than males at both examinations, but the difference was not statistically significant.

Adolescent↗

Determination of stress levels and profiles in the periodontal ligament by means of an improved three-dimensional finite element model for various types of orthodontic and natural force systems.

This study was undertaken to investigate the stress-strain levels and distribution within the periodontal ligament for various types of physiological and orthodontic force systems, assuming that the bone resorption process, leading to tooth movements, is partly controlled by those conditions. Two finite element models were developed, simulating a full and partial mandibular morphology, respectively. Both models were based on morphology and physical parameters of human autopsy material. The effect of changing material parameters and structure, type of boundary conditions, calculation method and fineness of the model on the stress levels and profiles in the periodontal ligament was evaluated by a series of tests. A structure optimization technique was used to investigate the load bearing characteristics of the mandible and the influence of the anisotropic material properties of both the mandible and the segment. A 'multiple modelling' technique based on both the mandible and the segment was developed to test various types of boundary conditions in the analysis of the segment. Results presented as 'stress profiles' showing the correlation between the applied force system and the stress distribution in the periodontal ligament, based on the improved finite element models, were established.

Biomechanical Phenomena↗

Material parameters and stress profiles within the periodontal ligament.

Levels and profiles of initial stress in the periodontal ligament after application of various force systems were studied. Two finite-element models, based on sections of human autopsy material, were developed to simulate one full and one partial mandible. The validity of the finite-element model was improved by identification of material parameters; the mechanical properties of the tissue were described by means of strain-gauge measurements of initial tooth movements in human autopsy material. The multiple modeling technique, in which data from a coarse global model are transferred to a more detailed one, was used to identify bone structure and boundary conditions. Parameters known to influence the results were varied to establish the validity of the finite-element model. Iterative calculation methods were used to gain stable results. However, optimizing features of the bone structure and boundary conditions did not influence the results significantly. The elastic stiffness of the periodontal ligament was determined to 0.07 MPa and tau = 0.49 (tau being the Poisson's ratio). Stress profiles were obtained for various force systems--as in tipping, translation, and root movement. As we expected, there was a marked variation in the stress distribution from cervix to apex when tipping forces were applied. Bodily movement of the tooth produced an almost uniform stress distribution; root movement produced stress patterns opposite to those observed during tipping; and masticatory forces alone produced stress patterns almost identical to those achieved by masticatory force in combination with orthodontic forces.

Adolescent↗

Tooth displacement analysed on human autopsy material by means of a strain gauge technique.

Tooth displacement was analysed on human autopsy material for various types of orthodontic force systems using an electronic strain gauge technique. Tooth movements were registered in two dimensions with low force clip gauges on three sections of the mandible, containing the first premolar and the first molar. The sensitivity was 0.1 microns when horizontal forces of 50, 100, and 150 cN were applied at different horizontal levels producing different M/F ratios. The relationship between a force system and the resulting tooth movement was described by the position of the centre of rotation, CR, and the angle of rotation. The centre of resistance was determined for the three autopsy specimens, and depended on tooth geometry, root length, and level of bony margin. Important differences in location were found. The dynamics of initial tooth movement were analysed within the first minute of load application. Force/displacement curves were generated to evaluate the behaviour of the periodontal ligament. There was a linear correlation between the two variables. Freezing the autopsy material some days before testing had no detectable effect. The results from measurements on human autopsy material were compared with previously derived in vivo measurements.

Adolescent↗

Occlusal contacts in maximum intercuspation and craniomandibular dysfunction in 16- to 17-year-old adolescents.

The relationship between number, distribution and intensity of occlusal tooth contacts and the craniomandibular functional status was investigated in 56 subjects aged 16-17 years. The photocclusion technique was used for the qualitative and quantitative evaluation of occlusal contacts, and a clinical examination was performed to assess the function of the stomatognathic system. According to a matched-pairs design two groups were formed, one consisting of individuals with signs of craniomandibular disorders, and the other consisting of functionally healthy adolescents. The pairs were matched according to morphological occlusal characteristics. The results of the present study emphasize the importance of occlusal contacts in relation to craniomandibular function. In particular the posterior occlusion appeared to be related to function, since statistically significant differences between the two groups were detected with regard to the number and load of contacts. Symmetry of intensity rather than symmetry of contact distribution per se seemed to be important in relation to craniomandibular function.

Adolescent↗

The nasal septum in relation to the development of the nasomaxillary complex: a study in identical twins.

The influence of the nasal septum and respiration, evaluated by the total nasal resistance (TR) on the development of the nasomaxillary complex, was studied in 42 identical twins. An understanding of this influence is important for a determination of whether surgery involving the nose should be performed in children. Comparison within and between twins with different septal deformities indicated that the cartilaginous nasal septum influences the development of the nose and the anteroposterior dimensions of the maxilla. Anterior septal deformities resulted in underdeveloped cartilaginous noses and a shorter anteroposterior dimension for the maxilla. No relation was found with regard to posterior septal deformities, which may be considered as part of the development of the midface. Vertical dimensions of the face were related to TR. Increased values of TR were significantly related to a shorter maxillary height. This may not express a causal relationship but rather genetically determined shorter facial dimensions.

Adolescent↗

Postnatal craniofacial skeleton development following a pushback operation of patients with cleft palate.

A longitudinal growth study of the craniofacial skeleton in 52 (19 males, 33 females) Danish individuals with cleft palates was performed. Thirty (13 males, 17 females) had clefts of the soft palate only or clefts extending into the posterior third of the hard palate. Twenty-two (6 males, 16 females) had more extensive clefts including up to two-thirds of the hard palate. The cleft was closed with a pushback operation at 22 months of age. Orthodontic treatment was included in the early mixed dentition. Lateral cephalometries were obtained at 5, 8, 12, 16, and 21 years of age. Twenty-four variables were digitized and analyzed. The results indicated that patients with more extensive clefts demonstrated significantly smaller anterior cranial base length (N-S), total cranial base length (N-Ba), maxillary dentoalveolar base length (A-PMP), mandibular length (Cd-Pgn), upper anterior and posterior facial heights (N-ANS and P-PMP), and total facial height (N-Gn). Patients with the more extensive clefts reached maximum growth spurt later than patients with less extensive clefts in all dimensions except the A-PMP and the lower and total facial heights.

Adolescent↗

[Can attachment gain be achieved by means of orthodontic measures?].

The influence of intrusive movement was analyzed in an animal experiment. The results indicate that the periodontal status previously observed might in fact be related to a clinically significant amount of new attachment. Since the intrusion is carried out in case of horizontal bone loss, this treatment is specially focusing on the situation which has the most doubtful prognosis by means of the current new attachment procedures. A possible explanation of the attachment gain demonstrated may be that the stretching of the periodontal ligament fibres at the marginal level generates a sort of natural filter reducing the down growth of the epithelium. Another possible explanation may be that the orthodontic stimulation increased the turnover in the periodontal ligament and thereby improved the chances of the periodontal ligament to repopulate the previous infected root surface. There is, on the basis of the results presented reason to believe that a combination of a prevented colonarization from gingival tissue and a stimulation of the periodontal ligament cells showed open new perspective in the treatment of heavily involved periodontal patients.

Analysis of Variance↗

[Biomechanics--where are we today?].

The development within the field of orthodontics is taking place within both the "hardware" (the brackets and wires) and within the "software" (the concepts behind the design of biomechanics). A survey of the physical characteristics of the new wires is presented. Within the "software" section the differentiation between appliance-guided and orthodontist-guided force systems is important. While the first is a standardized system, the second is goal-oriented and individualized. The advantage in segmented- contra straightwire-technique is discussed in relation to the limitation of orthodontics.

Dental Stress Analysis↗

Effect of biteblocks and repelling magnets on root formation of unerupted premolars in Macaca monkeys.

The effect of repelling magnets on the root formation of unerupted teeth was studied in monkeys. Four controls, four monkeys with acrylic biteblocks and four monkeys with repelling samarium magnets embedded in biteblocks were observed for 12 weeks. After the monkeys were killed the teeth were examined histologically and the root formation evaluated. A clear influence on both the predentine formation and the Hertwig's root sheath was observed. The results clearly indicate the need for more long-term studies on the tissue reactions produced by repelling magnets.

Animals↗