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Biomedical subjects

B Meier

Publications and source records attributed to B Meier.

494 records · Page 28Linked to original sources
PubMedDate not supplied

Serum lipoprotein levels fail to predict postangioplasty recurrent coronary artery stenosis.

A prospective study to explore the role of serum lipoproteins in the development of recurrent stenosis after percutaneous transluminal coronary angioplasty was conducted on serum samples from 103 patients. Serum was collected at the time of angioplasty and evaluated for total cholesterol, total triglycerides (TG), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, very low-density lipoprotein cholesterol, and apolipoproteins A1 and B. In addition, LDL cholesterol/HDL cholesterol ratios and apolipoprotein B/A1 ratios were calculated for each sample. Information was then gathered from four years of follow-up after angioplasty, which was sufficient to establish the presence or absence of recurrent stenosis in 87 patients (68 males and 19 females). Stenosis recurred in 31 of the 87 patients (36%); the rate was similar for males (35%) and females (37%). Univariate analysis of the total patient population revealed no statistically significant difference in values for any of these lipoprotein parameters between success and recurrence groups. Likewise, multivariate analysis revealed no combination of lipoprotein values to be associated with success or recurrence. Findings were similar for the males alone and the total group of males and females. The female group was too small for separate statistical analysis. The power of this study to detect meaningful differences in each of these parameters except TG was at least 80%. These results do not support the hypothesis that lipoprotein factors influence the development of recurrent stenosis in patients undergoing coronary angioplasty.

Angioplasty, Balloon↗
PubMedDate not supplied

Magnarail probing catheter: new tool for balloon recanalization of chronic total coronary occlusions.

The Magnarail probing catheter (Schneider Europe), a new tool for angioplasty of chronic total coronary occlusions, consists of a 135 cm/3.4 French single lumen shaft with the distal 17 cm (4.5 French) featuring a double lumen (Monorail section). The long lumen serves for contrast medium injection and pressure measurements. The short lumen accepts the guide wire and braces it to cross the occlusion. Once the lesion passed, the Magnarail probing catheter quickly can be exchanged for a balloon catheter. In case of failure to pass with the guide wire, no balloon is wasted.

Angioplasty, Balloon, Coronary↗
PubMedDate not supplied

Coronary angioplasty in the young: procedural results and late outcome.

Procedural outcome of coronary angioplasty in 89 patients < or = 40 years was compared to an older group of 1,916 patients > 40 years. Young patients were more often male (98% vs. 81%), smokers (89% vs. 70%), and more stressed (subjectively) (29% vs. 15%) compared to the older group. Other coronary risk factors were less common in the younger group: diabetes (5% vs. 13%), and hypertension (19% vs. 40%). Left ventricular function, number of diseased vessels, and the number and location of sites dilated were similar in the two groups. Procedural success rates were similar in the two groups (90% in young, 86% in old; p = NS). Younger patients suffered no major complications of the procedure, in contrast to a myocardial infarction rate of 5%, and urgent bypass surgery and mortality rates of 1% each in the older group. Young patients were followed up for a mean of 30 +/- 26 months after the procedure, with an actuarial 5-year survival of 100%. Four patients (5%) required elective coronary bypass surgery: two due to a failed angioplasty attempt (failure to cross), the other two for progressive multivessel disease. A total of 28 patients (34%) required re-angioplasty (restenosis: 13%, progression elsewhere: 12%, both: 9%). All re-angioplasty procedures were angiographically and clinically successful, with no major complications. For young patients, coronary angioplasty is a safe and effective procedure. If technically feasible, angioplasty should be considered the initial therapeutic option without neglecting risk factor modification.

Adult↗
PubMedDate not supplied

Early experience with coronary stenting.

From April 1988 to December 1991, we implanted 75 coronary stents (29 self-expanding and 46 balloon expandable) in 62 patients. All had New York Heart Association class II to IV angina, and 11 (18%) had prior coronary artery bypass grafting (CABG). Thirty nine patients (63%) had 1 vessel disease, and 23 (37%) had multivessel disease. The mean left ventricular ejection fraction was 63 +/- 11%. The indications for coronary stenting were acute post percutaneous transluminal coronary angioplasty (PTCA) occlusion in 45 (73%) (bail out stenting) and restenosis in 17 (24%) (elective stenting). There were 52 single stent (84%), 7 double stent (11%), and 3 triple stent procedures (5%). The mean stent diameter was 3.8 +/- 0.5 mm, and the mean stent length 21 +/- 7 mm. The attempted vessels were the left main coronary artery in 2(3%), left anterior descending coronary artery in 27 (44%), left circumflex coronary artery in 8 (13%), right coronary artery in 17 (27%), and a saphenous vein graft in 8 (13%). Technical success was achieved in 74 stent implantations (98%). Technical failure occurred in 1 case with a self expanding stent because of inability to reach the lesion. In hospital complications (mean hospital stay 10 +/- 10, range 2-60 days) included temporary stent occlusion in 2 patients (3%) treated by balloon dilatation and thrombolysis with intravenous urokinase, permanent stent occlusion in 5 patients (8%), Q-wave infarction in 5 patients (8%), CABG in 4 patients (11%), and death in 3 patients (5%). At least 1 major complication (Q wave infarction, CABG, or death) occurred in 8 patients (13%).(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMedDate not supplied

Determination of the Fusarium mycotoxins nivalenol, deoxynivalenol, 3-acetyldeoxynivalenol, and 15-O-acetyl-4-deoxynivalenol in contaminated whole wheat flour by liquid chromatography with diode array detection and gas chromatography with electron capture detection.

A rapid and sensitive method was developed for simultaneous detection of nivalenol (NIV), deoxynivalenol (DON), 3-acetyldeoxynivalenol (3-A-DON), and 15-O-acetyl-4-deoxynivalenol (15-A-DON) in wheat flour. Samples were extracted with acetonitrile-water (84 + 16), and the extract was filtered and purified by a column containing a combination of charcoal, celite, and other adsorbents. For screening analysis, the column eluate was only extracted with ethyl acetate. After evaporation of the solvent, the dried residue was redissolved in acetonitrile-water (2 + 8) and then analyzed by reversed-phase liquid chromatography (LC) with diode array detection. Recoveries of NIV, DON, 3-A-DON, and 15-A-DON from whole wheat flour spiked at 2 levels were 49-55, 92-97, 98-100, and 100-105%, respectively. To quantitate mycotoxin amounts lower than 1 ppm, purified column extracts were evaporated to dryness, derivatized with heptafluorobutyric anhydride, and analyzed by gas chromatography with electron capture detection (GC-ECD). Average recoveries of NIV, DON, 3-A-DON, and 15-A-DON from whole wheat flour spiked at 2 levels, were 45-52, 91-103, 81-85, and 84-92%, respectively. GC-ECD detection limits for all mycotoxins tested at a signal-to-noise ratio of 4:1 were < 30 ng/g. Results of GC-ECD analysis for whole wheat flour samples spiked with mycotoxins at 3 and 10 ppm compared well with results (2.8 and 9.9 ppm) for the same samples analyzed by LC.

Chromatography, Gas↗