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Biomedical subjects

B McCormick

Publications and source records attributed to B McCormick.

At least 127 records · Page 7Linked to original sources
PubMed1988

Iridium-192 implants for primary breast cancer: experience with placement at the time of wide local excision.

An Ir-192 boost is a technique frequently used to deliver an additional dose of radiation therapy to the tumor bed following breast conserving surgery and combined with external beam radiation therapy to the entire breast for patients with early breast cancer. Traditionally these catheters are placed following completion of 4500-5000 cGy, as a separate procedure. This paper described a Pilot Study identifying placement of the catheters at the time of primary wide local excision, or re-excision in 52 patients. The key to the success of this technique is the achievement of complete hemostasis in the primary cavity, the presence of the radiation oncologist during the surgical procedure itself, and closure of the wound prior to placement of the catheters. Details of the technique, and preliminary patient results are presented.

Adult↗
PubMed1987

Limited resection for breast cancer: a study of inked specimen margins before radiotherapy.

This is an analysis of tumor margins of 108 patients who underwent a limited resection for infiltrating breast cancer, prior to starting radiation therapy. This represented the initial resection (IR) in 75 patients, and a re-excision (RE) after biopsy elsewhere in 33 patients. All specimens were processed by the India ink method prior to frozen and paraffin section analysis. Overall, the incidence of involved margins was 28% for the IR group, and 15% for the RE group. No correlation was found with the axillary node status, or with the type of prior surgery in the RE group. The data suggest a correlation between increasing tumor size and margin involvement. Further surgery in the IR group with involved margins yielded negative margins in all cases; the finding of residual carcinoma was correlated with the type of secondary surgery, that is, further re-excision or mastectomy.

Biopsy↗
PubMed1987

Radiotherapeutic management of early breast cancer.

Radiation therapy has been used for the management of breast cancer for many years. Traditionally, it has been an adjunct to the radical mastectomy, but in recent decades major centers have initiated studies replacing the mastectomy with a more limited surgical procedure and, at the same time, have increased the irradiated volume to include all the remaining breast tissue.For early, infiltrating duct breast cancer, results of these studies using modern therapy units combined with appropriate local surgery have been consistent and comparable in both local control and long-term survival to published results with the modified mastectomy. The definition of "early breast cancer" and how should it be applied to the patient is discussed for both clinical stage I and stage II breast cancer patients following a brief review of the major studies.

Breast Neoplasms↗