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Biomedical subjects

B McCarthy

Publications and source records attributed to B McCarthy.

At least 37 records · Page 2Linked to original sources
PubMed1989

Management of multiple enterocutaneous fistulas.

Enterocutaneous fistulas present a difficult management problem in the intensive care unit. Although some patients require surgical intervention for fistula control, key elements to good clinical management include mechanical control and vigorous nutritional support. This approach includes eradication of malnutrition, support of the hypercatabolic state, and maintenance or replacement of protein loss from fistula drainage. Good mechanical control involves integument protection and a mechanism of drainage collection. The patient we describe taxed the ingenuity and creativity of all those concerned with his care. Modification of a previously described technique to protect surrounding skin and collect fistula output served as a simple and inexpensive approach to eliminate infection potential, improve the patient's comfort, and decrease the nursing time that would have been required for frequent, complex dressing changes.

Aged↗
PubMed1988

Iodine concentrations in milk of dairy cattle fed various amounts of iodine as ethylenediamine dihydroiodide.

Due to concerns about high I in milk, the dairy industry has proposed a voluntary standard of 500 micrograms of I/L as the maximum allowable I in milk sold for processing and human consumption. This study was undertaken to determine the amount of ethylenediamine dihydroiodide that could be fed to dairy cattle without exceeding this standard. Various amounts (0 to 45 mg/head per d) of the I compound were fed to a commercial dairy herd for 50 wk. Individual and bulk milk samples were analyzed for total iodine. Milk I in herd bulk milk was directly correlated (r = .92) with the amounts fed. However, the correlation of milk I of individual cows was not as high (r = .66), indicating some individual variation in metabolism and secretion of the I into the mammary gland. Milk production and number of lactations did not correlate with I in milk. Regression analysis indicated that 25 to 30 mg of ethylenediamine dihydroiodide per day can be fed to dairy cattle receiving a diet otherwise low in I without exceeding a 500 micrograms concentration in milk.

Animals↗
PubMed1987

[High postneonatal mortality of infants in North Rhine Westphalia].

Infant mortality in North-Rhine Westphalia was increased above the national average throughout the postwar period until today. To clarify the underlying causes the official death certificates of infants who died during their first year were linked to their respective birth certificates. Thus, the amount of data about each individual case was increased considerably. The information collected was then evaluated. An especially high mortality was associated with the maternal risk factors illegitimacy, age below 20 and Turkish nationality. Perinatal mortality was high in the groups of Turkish nationals, and unmarried mothers. Socially underprivileged groups on the whole proved to contribute a high amount of postneonatal mortality. Predominant causes of postneonatal mortality were infections, injuries and the diagnosis "sudden infant death syndrome".

Birth Weight↗
PubMed1981

The risk of childbearing re-evaluated.

To determine the completeness of reporting of maternal deaths after live born deliveries in Georgia for 1975 and 1976, we matched death certificates with corresponding birth certificates for women of reproductive age. For these two years, more intensive searching led to our finding a minimum of a 27 per cent higher number of maternal deaths than that found by routine death certificate surveillance. When the delivery-death interval was not restricted to 42 days, use of the record linkage method led to a 50 per cent increase in reporting of maternal deaths. We recommend that special efforts be made to obtain more complete reporting of all pregnancy-related deaths and that completeness of reporting be periodically evaluated for all states.

Adolescent↗
PubMed1976

Toxic megacolon of ulcerative colitis in infancy.

A 12-week-old white male infant with ulcerative colitis and toxic megacolon is described. His diarrhea and rectal bleeding responded to prednisone. He subsequently developed toxic dilatation of the transverse colon while on salicylazosulfapyridine and one week after discontinuation of prednisone. His toxic megacolon disappeared during close medical observation, readministration of prednisone, and avoidance of repeated abdominal examinations. One year later sigmoidoscopy showed only friable mucosa and the barium enema showed the presence of ulcerative colitis but with improvement from the initial study. Currently he is taking 375 mg of salicylazosulfapyridine daily. Growth and development are normal and he is asymptomatic.

Colitis, Ulcerative↗
PubMed1975

Location of histones on simian virus 40 DNA.

The physical location of histone molecules in a simian virus 40 DNA-histone complex isolated from purified virions was examined using site-specific restriction endonucleases. The complex contains four host histone species but lacks histone F1. Histones prevent complete cleavage of SV40 DNA by two restriction enzymes, HindIII and EcoRI. From the pattern of DNA fragments resulting from cleavage of the histone-DNA complex by the HindIII endonuclease, which makes six breaks on purified SV 40 DNA, we have concluded that histones are randomly arranged on SV40 DNA relative to restriction enzyme cleavage sites. The EcoRI endonuclease, which makes one break in SV40 NDA, was used to determine the degree of physical coverage of the SV 40 DNA molecule by histones. We observed that 80% of the EcoRI sites in the complex are accessible to the enzyme while 20% are "closed." This degree of coverage is consistent with the mass ratio of DNA:histone in the complex as revealed by the buoyant density of the formaldehyde-fixed complex. We conclude that the histones in the complex are located randomly on the SV 40 genome and cover approximatley 20% of the DNA. These results suggest that the histone species F2b, F2al, F2a2, and F3 are bound without regard to nucleotide sequence of SV 40 DNA.

Binding Sites↗