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Biomedical subjects

B May

Publications and source records attributed to B May.

At least 145 records · Page 8Linked to original sources
PubMed1983

[Spontaneous bilio-digestive fistula after intraoperative choledochus ligation].

Intraoperative lesions of the extrahepatic bile ducts during cholecystectomy do occur; the incidence is about 0.2 to 0.8%. Lesions of the hepatic duct and the choledochus duct followed by stenosis (usually of the cystic duct confluent) do occur most frequently. Intraoperative ligation of the hepatic duct or the choledochus duct are the most severe sequelae of biliary surgery; the leading symptom is progressive postoperative obstructive jaundice. A bilio-digestive fistula may be formed spontaneously and may masquerade this complication leading to relapsing cholangitis. Pathogenesis, clinical symptoms and therapy of bilio-digestive fistula are discussed, after an own case report is given.

Aged↗
PubMed1982

[Hematologic and dermatologic side-effects of antibiotic therapy].

The report details possible haematological and dermatological side effects due to co-trimoxazole: agranulocytosis and epidermiolysis bullosa (Lyell) respectively developed after short-term therapy with co-trimoxazole in two women treated for tonsillitis and acute relapse of chronic obstructive bronchitis respectively. The clinical findings, therapeutical management and clinical outcome of both patients are described. Reviewing the literature the relevance of co-trimoxazole induced side effects is discussed.

Aged↗
PubMed1982

Joint segregation of biochemical loci in salmonidae. III. Linkage associations in Salmonidae including data from rainbow trout (Salmo gairdneri).

The results of 107 pairwise examinations of joint segregation of biochemical and skin color loci in rainbow trout, Salmo gairdneri, are presented. Three examinations revealed significant nonrandom assortment: Idh-3 with Me-2, Ada-1 with G3p-3, and Mdh-3, with Mdh-4. We believe the first two instances to be cases of classical linkage and the latter instance to reflect pseudolinkage based on similar findings in Salvelinus. All known salmonid linkage associations are reviewed. The results of this summary indicate a high degree of genome conservatism among genera within the Salmonidae, which would seem to be in contrast to the highly plastic genome of this family based on karyotypic data. Data are presented which negate the view that Robertsonian fusion of homologous acrocentric chromosome arms was the preferred mode of metacentric formation in salmonid evolution.

Albinism↗
PubMed1982

Genetic variation and joint segregation of biochemical loci in the common meadow mushroom, Agaricus campestris.

In this paper we report the results of an electrophoretic examination of genetic variation in the common meadow mushroom, Agaricus campestris. An examination of variability at 10 biochemical loci in a single natural population revealed an average heterozygosity of 0.281. Mendelian segregation was verified for 13 loci in single-spore-derived lines from individual sporophores. One linkage was found (Gpt-2 with Pep-GL-1, r = 0.065) among 47 pairwise examinations for joint segregation.

Basidiomycota↗
PubMed1981

[Liver changes in acute rheumatic fever].

Following the course of disease in a 19 year old patient with acute rheumatic fever we report the reaction of the liver parenchyma: on histological examination besides a marked steatosis several "unspecific" granulomas were seen. Nutritional and toxic factors were excluded aetiologically. Difficulties in diagnosis and differential diagnosis of acute mono/poly-arthritis as a leading symptom are discussed.

Acute Disease↗
PubMed1981

[How strongly does heavy work in the heat affect metabolism?].

The study covered 39 acclimatised workers of a ball-bearing forge, aged 39,03 +/- 9,95 years. Temperature of the air, relative humidity and air speed were measured immediately at work. Additionally electrocardiogram, heart rate and temperature of the skin were continuously transmitted by telemetry. Before and at the end of the shift analysis of blood pressure, heart rate, electrocardiogram, blood cells and coagulation, serum acidity and a great number of other metabolic parameters was performed. The netto calories were calculated as 3250 kcal/8 hours (= 13585 kJ/8 hours). Hematological analysis demonstrated a tendency to increase of leucocytes favouring neutrophil granulocytes. The main alterations comprised decrease of actual pH, base excess and standard bicarbonate. Furthermore serum lactate and triglycerides increased, creatinine attained the upper limit of the normal range, mineralogram remained unchanged by drinking ad libitum. The so called "liver enzymes" remained stable. As to circulatory parameters systolic blood pressure slightly declined whilst heart rate increased.

Acid-Base Equilibrium↗
PubMed1981

Loss of duplicate gene expression in salmonids: evidence for a null allele polymorphism at the duplicate aspartate aminotransferase loci in brook trout (Salvelinus fontinalis).

Unusual phenotypic distributions at the muscle-specific, duplicate aspartate aminotransferase (AAT) loci were found in wild populations of brook trout (Salvelinus fontinalis), a species of the tetraploid-derivative Salmonidae. Analysis of these phenotypic distributions ruled out disparate gene frequencies, nonrandom association between the two loci, and inbreeding as possible explanations; however, models incorporating a null allele fit the data. Inheritance data from hatchery populations of brook trout also indicated a null allele polymorphism. This proposed AAT null allele, along with other null allele polymorphisms in salmonids, is evidence that loss of duplicate gene expression is still occurring. In contrast, there is no such evidence of ongoing loss of duplicate gene expression in the Catostomidae, another tetraploid-derivative lineage. We interpret this and other differences between salmonids an catostomids as reflecting an autotetraploid origin for salmonids and an allotetraploid origin for catostomids. The significance of these findings is also considered with respect to current models of the rate of loss of duplicate gene expression in tetraploid-derivative organisms.

Alleles↗
PubMed1981

[Cholesteryl ester storage disease in the liver (author's transl)].

Cholesteryl ester storage disease is a rare disorder if cholesterol metabolism characterized by excessive hepatic storage of cholesteryl esters. The underlying defect probably is decreased activity of alpha-naphtyl-acetatesterase, a lysosomal acid lipase. The leading symptom in the early stage is a pronounced enlargement of the liver without subjective complaints or other changes in the physical status. Diagnosis can be established by liver biopsy, which will yield characteristic findings, and by exclusion of other storage disease. Histologic examination of the biopsy specimen will show lipid droplets in hepatic parenchymal cells, vacuolated Kupffer cells and focal accumulation of foamy cells. Biochemical analysis of the biopsy specimen will show an increased content of cholesteryl esters. Investigation of media of culture fibroblasts will show decreased activity of lysosomal alpha-naphtyl-acetat-esterase. In addition adrenal calcification has to be ruled out, in order to exclude wolman's disease. The prognosis of the disease will depend upon the degree of liver insufficiency, since lympho-histiocytic infiltration as a secondary phenomenon may lead to septal fibrosis and cirrhosis in children or adolescents in most cases. A case report is given of a 13-year old girl suffering from this disease.

Adolescent↗
PubMed1980

[Occupational liver diseases: (author's transl)].

A large number of exogenous substances with potential liver toxicity are to be found in work places and in the environment. Decisive importance is ascribed to regular supervision of exposed persons and adhering to the appropriate safety provisions without being able to ensure reliable prevention of toxic liver damage thereby. The prognosis of occupational toxic liver damage is good if recognition is timely and the causal noxae are eliminated. The aim of all diagnostic and prophylactic efforts must be rehabilitation, in addition to specific occupational medical and hygienic measures.

Arsenic Poisoning↗