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Biomedical subjects

B Mathiesen

Publications and source records attributed to B Mathiesen.

At least 19 recordsLinked to original sources
PubMed2005

Relation between diagnoses on severity, sick leave and loss of job among patients with occupational hand eczema.

BACKGROUND: Epidemiological studies indicate that occupational hand eczema (OHE) often is associated with persistent dermatitis and prolonged sick leave, which may lead to unemployment. Previous studies suggest that OHE caused by allergic contact dermatitis and atopic dermatitis (AD) carries the worst prognosis. OBJECTIVES: To evaluate and compare the severity and consequences of recognized OHE in different diagnostic and subdiagnostic groups. METHODS: Between October 2001 and November 2002, all new cases of recognized OHE were identified from the Danish National Board of Industrial Injuries Registry (758 cases). Severity was graded from 0 to 2 depending on the intensity of skin response and the frequency of relapse. To supplement the information from the Registry, we surveyed the study population using a postal questionnaire which included questions about disease duration, sick leave, current occupation and loss of job. RESULTS: The overall response rate to the questionnaire was 82%. We observed substantially greater severity among those with occupational irritant contact dermatitis (ICD) and AD than for any other diagnoses. Age above 50 years was also associated with increased severity of OHE. Prolonged sick leave due to OHE was reported by 19.9% and was associated with AD and severe OHE. We found a higher proportion of prolonged sick leave among those in food-related occupations (27.2%) compared with those in wet occupations (20.1%) and other occupations (16.5%). Twenty-three per cent reported that they had lost their job at least once during the past 12 months due to OHE. The only strong association with loss of job was food-related occupations. CONCLUSIONS: Occupational ICD and AD appear to be strongly associated with severity of OHE. AD and severity of OHE were independently associated with prolonged sick leave. Having a food-related occupation appears to be associated with increased risk of loss of job.

Adolescent↗
PubMed1997

Diabetes and accident insurance. A 3-year follow-up of 7,599 insured diabetic individuals.

OBJECTIVE: Individuals with diabetes pay increased premiums and experience limited coverage when taking out accident insurance, despite the lack of scientific support for this practice. The aim of the present study was to analyze whether diabetic individuals have an increased risk of accident or an increased risk of permanent disability after an accident, compared with two nondiabetic groups. RESEARCH DESIGN AND METHODS: All diabetic members of the Danish Diabetes Association were given free accident insurance for a 3-year period. Based on informed consent, they were also asked to participate in a follow-up study, comparing accident rates in diabetic individuals with a nondiabetic group. A total of 7,599 diabetic members accepted. The control groups were 1) individuals with a leisure-time insurance in the same company (individual issue) and 2) members of full-time group-based insurance (bank employees) in the same company. RESULTS: The risk of accidents was 0.7 per 1,000 person-years in the diabetic group, compared with 4.5 per 1,000 person-years in the first and 5.5 per 1,000 person-years in the second nondiabetic control group (P < 0.001). The degree of permanent injury did not differ between the diabetic and the nondiabetic group. CONCLUSIONS: The risk of accidents and permanent disability is not increased in diabetic individuals. Thus, diabetic individuals should be offered accident insurance at a standard premium without limited coverage.

Accidents↗
PubMed1996

Sustained-release metoclopramide plus methylprednisolone versus placebo plus methylprednisolone as antiemetic prophylaxis during non-cisplatin chemotherapy. A randomized double-blind cross-over trial.

In a randomized double-blind cross-over trial, sustained-release metoclopramide (S) plus methylprednisolone (M) was compared with placebo (P) plus methylprednisolone as antiemetic prophylaxis during two cycles of non-cisplatin chemotherapy. S was administered as 60 mg every 12 h commencing on the evening before chemotherapy up to total of 300 mg metoclopramide in 2.5 days. Evaluation of nausea and vomiting was done by self-assessment schemes and visual analog scales. Fifty patients were included and 36 fulfilled both cycles. Mild nausea and vomiting were experienced by 81% and 83% in the S + M and P + M groups, respectively, while 42% and 39% showed complete control of nausea and vomiting during the first day of treatment. Moderate-dose S did not add to the antiemetic efficacy of M in non-cisplatin chemotherapeutic regimens.

Adult↗
PubMed1993

Rebox: an adjunct in physical medicine?

Electrical therapy is used extensively in the treatment of musculoskeletal diseases. The best known form is transcutaneous electrical nerve stimulation (TENS). Rebox is another apparatus for electrical therapy that operates on much lower currents than TENS (0 to 300 microA). The effect of Rebox was tested on chronic lateral epicondylitis in 16 patients in a controlled crossover study. We found a significant effect of Rebox compared to placebo in respect to all the subjective and the objective variables: grip-strength, pain at power-grip and lifting a weightload with pronated forearm, and daily impairment.

Adult↗
PubMed1992

[Handling and decisions by the authorities of reported occupational tendon injuries of the upper extremities. Occupational diseases' registry E6b].

The aim of this investigation was to show how the Danish National Social Security Office, (the department of industrial injuries insurance (NSS)), handles the cases and makes the final decisions concerning the diseases in tendons in the upper extremity belonging to the list of occupational disorders in the Danish Workers' Compensation Act. Five hundred and nineteen notified cases were followed-up until the final solution and eventual compensation for permanent injury and loss of earning capacity. Two hundred and twenty-six cases had to be excluded because the criteria in the list of Occupational Disorders concerning unusual work and complete or partial inability to work were not fulfilled. Sixty-seven commenced work again after the notification and forty four did not reply to the NSS correspondence. One hundred twenty-seven had to be eliminated for other reasons. Fifty-five cases could be further investigated according to the workload criteria. fourteen were accepted and forty-one were rejected. Eight of these were paid a total compensation for permanent injuries amounting to 200,000 DDK and a capitalized compensation for loss of earning capacity amounting to 1,000,000 DDK. The notified diseases occurred among unskilled workers in their forties, equally frequently in men and women. It takes a long time to obtain the answers to NSS correspondence from doctors as well as the injured persons and therefore a total handling time of up to one year has to be expected. Our conclusion is that it is difficult to have these diseases accepted as being caused by the work because the criteria on the list about "unusual work" and "complete or partial inability to do normal work" exclude many cases from acceptance. Probably the criteria for workload should be changed so that it is based on an objective goal for the workload and the movements to a greater extent compared with the exposure time. Doctors who report the diseases should be more precise in the notified diagnosis, symptoms and the workload responsible.

Denmark↗
PubMed1990

Core decompression for femoral head necrosis. Prospective study of 28 patients.

Totally, 28 consecutive patients with nontraumatic osteonecrosis of the femoral head were included in a prospective study of the clinical and radiographic results of core decompression. One patient (one hip) was lost to follow-up. Preoperatively, the stage according to Ficat (1985) was assessed by plain radiography and scintimetry. After 1-2 years, hip replacement had been performed in 4/11 Stage 1, 7/11 Stage 2, and 4/7 Stage 3 hips, while the remaining 12 hips were judged satisfactory. We conclude that the outcome of core decompression for nontraumatic necrosis of the femoral head is unpredictable.

Adult↗
PubMed1989

[Injury patterns on the first icy day of winter--a survey in Copenhagen County].

The injuries on the first icy day of the winter 1986-1987 in Copenhagen County were compared to the injuries on the preceding day. There were 368 and 276 injuries (both days 95 non-surgical) respectively. The significant increment of fractures and emergency hospitalization was mostly due to fractures of the wrist, humerus and femur. Only a few sprains of the ankle were registered. The majority of patients were middle aged and elderly women. The economical and personal consequences are considerable, but impossible to evaluate, as reliable statistics are needed. Intensive snow clearing and recurrent propaganda are recommended.

Accidental Falls↗
PubMed1985

Occupational capacity after hip replacement.

Working capacity and dependence on the social welfare system were analyzed in 387 patients 5 years after hip replacement. Significant pre-operative factors were age, etiology of the hip disease and walking ability, and at the follow-up age, walking ability, pain and subjective experience of satisfaction with the operation. Among patients working pre-operatively, 92 per cent kept on working, and 70 per cent of patients on sick-leave went back to work. Only 9 per cent of patients working or sick-listed pre-operatively became invalidity pensioners, but none who were pensioners pre-operatively went back to work.

Adult↗
PubMed1982

Magnesium deficiency in chronic alcoholic patients uncovered by an intravenous loading test.

Magnesium sulphate (30 mmol in 1 litre NaCl solution, 154 mmol/l) was infused over 8 h i.v. in overnight fasted reference group (n = 12) and chronic alcoholics (n = 16) with normal kidney function. The magnesium excreted in the urine was measured in the 24 h urine beginning at the start of the infusion. Alcoholics excreted 1-15 mmol magnesium (median 6.4) and the reference group 18-30 (median 23.2) in the 24 h after the load. When the loading was repeated in the alcoholics (n = 7) after having received a hospital diet supplemented with 150 mmol magnesium citrate for 10 days, the elimination in the urine increased from 1-12 mmol (median 6.1) to 14-25 (median 20.8) close to the results in the reference group. The elimination in the urine was highly correlated (rs = 0.7) to the serum albumin concentration. The amount of magnesium eliminated in the urine by the reference group and the chronic alcoholic patients did not correlate with their serum concentrations of magnesium. The magnesium loading test in adults clearly separates a reference group from the magnesium deficient chronic alcoholics and can be used both for the diagnosis of magnesium deficiency and to follow the individual patient during repletion.

Alcoholism↗