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Biomedical subjects

B Martini

Publications and source records attributed to B Martini.

62 records · Page 4Linked to original sources
PubMed1982

[Atrial fibrillation and flutter in children].

Flutter and atrial fibrillation are extremely rare in children. Their aetiology and pathogenesis vary from one case to another. The clinical picture may be influenced by a number of factors (age, duration of the arrhythmia, ventricular frequency), while the natural history is often related to the presence or otherwise of associated cardiopathies. There is no standard treatment. Digitalis with or without other antiarrhythmic drugs is often employed as the drug of choice, though its place may be taken by ayodarone or verapamil.

Anti-Arrhythmia Agents↗
PubMedDate not supplied

Argon laser lesions of the retina; occurrence and origin of macrophages.

Macrophage infiltration is frequent in the early stages of various proliferative eye disorders, including subretinal neovascularization. In this study, we set out to establish the origin of macrophages found in an animal model of laser-induced subretinal neovascularization. One primate received several intravenous injections of a colloidal carbon suspension. We then applied standard argon laser lesions to the retina of both eyes, which were enucleated eight days later and sectioned serially for histological examination. A quantitative estimate of carbon-laden and non-laden leukocytes was made based on morphological criteria. Mononuclear leukocytes accumulated in the laser lesions and the percentage of carbon-laden mononuclear leukocytes in relation to the total leukocyte number was higher in the extravascular area of the laser sites than in the systemic circulation. These findings indicate that the majority of mononuclear leukocytes that accumulate at the sites of laser lesions are derived from the systemic circulation.

Animals↗
PubMedDate not supplied

Abnormal H-Tfam in a patient harboring a single mtDNA deletion.

We report on a patient suffering from a progressive mitochondrial disorder characterized by ocular myopathy, exercise intolerance, and muscle wasting. Morphological examination of muscle biopsy showed increased variability in fiber size and scattered ragged-red fibers. Analysis of muscle mitochondrial DNA by Southern blot and PCR revealed a heteroplasmic single deletion of 4100 base pairs, located between nucleotide positions 8300 and 12,400. Western blot analysis showed high levels of the human mitochondrial transcription factor A (Tfam). Interestingly, we also detected an additional Tfam product, of approximately 22 kDa. This is the first case in which a qualitatively abnormal Tfam has been found to be associated with a mitochondrial disorder in humans.

Biopsy↗
PubMedDate not supplied

[Unusual manifestations of Ebstein's disease in a 53 year old adult. Ebstein's disease in an adult].

B.P., asymptomatic until her fifties, was admitted to hospital because of precordial pain. Her ECG and chest X rays were normal. When 52 she was again admitted, because of congestive heart failure. ECG showed repolarization abnormalities and chest X rays showed marked cardiomegaly. 2d echocardiogram was consistent with right atrial dilatation, dislodged posterior leaflet of the tricuspid valve and marked tricuspid regurgitation; these features were consistent with Ebstein anomaly. The patient was successfully treated by digitalis and diuretics. This case shows that in very rare cases this congenital heart disease can produce its clinical manifestations only late in lifetime.

Ebstein Anomaly↗
PubMedDate not supplied

[Arrhythmogenic myocardiopathy of the left ventricle: dynamic ECG. Morphologic data and age of the patient in the prediction of the onset of arrhythmic events].

In 57 patients with arrhythmogenic right ventricular cardiomyopathy, 34 males 23 females, aged 5 to 60 average 27.93 years, arrhythmias recorded during the whole clinical history have been compared with the 24 hours ECG ambulatory monitoring data, age and anatomic extension of the disease. In 77.77% of patients with history of sustained ventricular tachycardia Holter monitoring showed Lown class less than or equal to 3 arrhythmias, in 75% of patients with ventricular fibrillation Holter monitoring showed no arrhythmias. 55.88% of patients whose Holter monitoring documented Lown class less than or equal to 3 arrhythmias had more severe arrhythmias in their history. There is not a close relation between Holter data and arrhythmias that occurred during the whole history; however, Holter monitoring is a useful tool in evaluating risk when it shows complex arrhythmias.

Adolescent↗