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Biomedical subjects

B Martin

Publications and source records attributed to B Martin.

At least 505 records · Page 28Linked to original sources
PubMedDate not supplied

Plasma concentrations and pharmacokinetics of misonidazole after intraperitoneal administration to the mouse.

The pharmacokinetics of misonidazole, a hypoxic-cell radiosensitizer, were determinated after intraperitoneal administration to standardized Balb/c mice. The experimental data was fitted, using non linear analysis, to plasma-concentration curves described by tri-exponential equations derived from a two-compartment model. The pharmacokinetic constants (absorption and elimination coefficients) were determinated.

Animals↗
PubMedDate not supplied

Absence of pyrimidine insertase activity in E. coli extracts, using plasmid DNA containing apyrimidinic sites.

Plasmid DNA, isolated from mutants of E. coli that are deficient in both uracil-DNA glycosylase and deoxyuridine triphosphatase, contains significant amounts of uracil. This can be removed in vitro by the action of uracil-DNA glycosylase, creating apyrimidinic sites. We have used depyrimidinated plasmid DNA isolated in this way to test the ability of E. coli extracts to preferentially incorporate labeled deoxythymidine triphosphate. No pyrimidine-insertase activity was found in extracts of bacteria that were deficient in exonuclease III. The question of the existence of such an activity in E. coli cells is discussed.

DNA Repair↗