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Biomedical subjects

B Martin

Publications and source records attributed to B Martin.

At least 469 records · Page 26Linked to original sources
PubMed1976

Steroid-protein interactions in bovine plasma.

The binding of testosterone, corticosterone and 17alpha-hydroxyprogesterone by bull plasma protein was studied by equilibrium dialysis. Testosterone in bovine plasma was bound by a CBG-like protein and by a specific protein (testosterone-binding protein or TBP) of limited capacity and high affinity. The TBP was specific for C18 and C19 steroids with a 17 beta-hydroxy group. Precision of the steroid-protein binding measurements was tested and was satisfactory. The testosterone-binding capacity in bull plasma samples did not seem to be related to testosterone levels in peripheral plasma. Significant differences between bulls and cows with regard to the binding capacity were observed.

Animals↗
PubMed1976

Combination of membrane oxygenator support and pulmonary lavage for acute respiratory failure.

A 24-year-old woman with chronic granulocytic leukemia and alveolar proteinosis required extracorporeal membrane oxygenator support for respiratory failure refractory to conventional therapy. During perfusion, each lung was lavaged with 10 L. of normal saline. The lavage led to marked clearing of the lungs and improvement in pulmonary function. Extracorporeal support was terminated successfully after 54 hours. The patient died 2 weeks later with bone marrow insufficiency and overwhelming sepsis. Pulmonary lavage is technically feasible during venovenous oxygenator bypass, and may be of value, since such lavage debrides alveoli as well as the bronchial tree. Because pulmonary lavage provides a possible means of improving pulmonary function, it seems worthy of consideration as an adjunct to membrane oxygenator support.

Adult↗
PubMed1976

Chiang Mai and Illinois: a cooperative international project, 1962-1970.

Participants in the Chiang Mai-Illinois Project had unique opportunities to work toward the goals of medical education in an attractive but alien environment. Concepts concerning public health and preventive medicine did not have high priority as the new medical school at Chiang Mai began, but a growing department made some progress in the teaching of these concepts with discussions, library and record room projects, and limited village investigations. Studies of hospital and clinic patients and of specific diseases disclosed useful data about northern Thai people. A productive experience in the foreign setting is believed to require sound training, energy, adaptability, and an investment of years.

Education, Medical↗
PubMed1976

Freeze-fracture replication of cultured Pityrosporum orbiculare.

Skin scrapings from a patient with Pityriasis versicolor were plated on a bile salt medium containing 10% glycerol (for cryoprotection) and Pityrosporum orbiculare was harvested for freeze-fracture replication. Resting and budding cells were senn. The overall pattern of indentation of the plasma membrane towards the cytoplasm was well revealed as a spiral arrangement of major indentations with minor ones disposed more or less at right angles. Hexagonally-arranged particles were not observed. Mitochondria were elongated with constrictions at intervals, and the fracture face of the limiting membrane directed towards the exterior exhibited linear arrays of particles. An unusual type of organelle was also present, viz: a membrane-limited vesicle with regularly-spaced depressions or "dimples".

Cell Membrane↗
PubMed1975

[Relationship between testosterone binding proteins and testosterone and LH plasma concentrations in the young bull].

Plasma levels of testosterone and LH were measured by radioimmunoassay from blood samples of young bulls of 9 to 15 months of age. The binding constants of specific testosterone binding plasma proteins were determined from the same samples. No significant difference of these values could be seen during the 25 hr. sampling period, contrary to large fluctuations in testosterone and LH plasma concentrations. But, the testosterone binding constants values were significantly lower after puberty (15 months) than at 9 and 12 months of age.

Animals↗
PubMed1975

A rapid, quantitative determination of clottable fibrinogen unaffected by heparin.

A turbidimetric assay for clottable plasma fibrinogen which is not sensitive to heparin or Pyran inhibition is described. The basis of the assay is the substitution of Reptilase-R for the thrombin usually employed. The assay correlates very well with a thrombin turbidimetric method and also has other advantages, including better stability of the clotting enzyme and more rapid attainment of equilibrium.

Fibrinogen↗
PubMed1975

Controlled release of subretinal fluid.

Drainage os subretinal fluid is generally regarded as being unnecessary when local buckling procedures are carried out, particularly when the buckle is placed radially, unless the patient has chronic glaucoma or the choroidal vessels are markedly sclerosed.However, there are many cases of retinal detachment where the eye is otherwise normal and where radial procedure is the detachment operation of choice in which a limited and controlled release of subretinal fluid will help considerably in the localisation, treatment by cryotherapy and final positioning of the tear on the buckle. This paper describes the technique employed and the advantages which may be gained by using this method in cases of deep bullous detachment of the retina. The results which have been obtained in cases in which this method has been used during the last 3 years are described.

Cryosurgery↗