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Biomedical subjects

B Marinov

Publications and source records attributed to B Marinov.

At least 37 records · Page 2Linked to original sources
PubMed2000

[Application of Hyaluricht in the treatment of wounds].

The aim of the present study is to evaluate the effectiveness of the drug Hyaluricht-Richter in the treatment of uncomplicated and complicated wounds in the obstetrical surgical practice. 54 women were included in the study. 47 of them were operated with Cesarean section (CS) and there were 7 cases were parlus normalis with episiotomy. The operative wounds of 30 of the patients with CS were clinically clean while the rest 17 were contaminated. All 7 episiotomies were problematic. The treatment of the wounds was performed 4 times daily in minimum beginning from the 2-3 postoperative day. In all problematic cases the treatment ended with limited complications, healing of the partial cicatricle dehiscence, elucidation of wound secretions, fast and new granulation and healing per secundam for about 10 days. Hyaluricht has a definite antiexudative, vasoprotective and fibrinoprotective effect. The drug is easy for application, it does not irritate the skin and it is suitable in the ambulatory practice for treatment of uncomplicated wounds and some selected problematic wounds.

Adult↗
PubMed2000

[Tri-Regol and its application in gynecological practice].

One of the most common side effects of the low-dosed estrogen monophasic preparations with selective progestin are breakthrough bleedings and spotting. The aim of the study is to evaluate the contraceptive and therapeutic abilities of the preparation Tri-Regol produced by Gedeon Richter Ltd., Budapest as a suitable alternative to the monophasic preparations. The study includes 29 women at the ages between 19 and 28, non-smokers, who have not given birth. The duration of the observation and the monitoring is 4-6 months (149 cycles altogether). During the first month of administration of the drug, breakthrough bleeding was registered with 5 women (17.2%) and spotting with 2 women (6.8%). During the third month only one woman reported scarce breakthrough bleeding (3.4%). With all the 149 cycles not a single pregnancy was registered. Pearl index--0. With all the patients ovulation was restored within three months after discontinuing the administration of the preparation. The side effects were rare in appearances and tended to decrease and finally disappeared with prolonging the period of administration. The established very good control over the menstrual cycle, the high rate of contraceptive security, the quick restoration of the ovulation accompanied only by rare, mild and discontinuing side effects give us sufficient grounds to recommend the application of the preparation Tri-Regol, product of Gedeon Richter Ltd., Budapest to young women who have not given birth and to women with strongly demonstrated or persisting breakthrough bleedings when treated with low-dosed monophasic preparations.

Adult↗
PubMed2000

[Diagnostic algorithm and software for assessment and follow-up of dyspnea].

Breathlessness is a common complaint among patients with lung and heart diseases. It is a complex, multidimensional symptom with descriptive and quantitative aspects. The aim of this study is to constitute a set of questionnaires and scales for adequate assessment of dyspnea and their combination in diagnostic algorithm with various ranges. In order to achieve this goal, we developed a software product DISKO with the following characteristics: Includes the basic instruments for assessing dyspnea in all dimensions--verbal (descriptive) characteristic, everyday activities and exercise dyspnea, as well as its impact on the patients' quality of life. Proposes minimal, optimal and comprehensive algorithm for assessment and follow up of dyspnea. Presents a convenient interface and an ability to configure a flexible data base easy for browsing and handling. Proposed tests and algorithm for dyspnea assessment make it easier for the physician to diagnose and follow up chronically ill patients whose major complaint is dyspnea. The software product DISKO is compliant with the modern requirements for medical software and can be utilized in the process of diagnostic, education and scientific research.

Algorithms↗
PubMed2000

Ventilatory response to exercise and rating of perceived exertion in two pediatric age groups.

The aim of this paper is to study the differences in ventilatory response to exercise in prepubertal and pubertal children. One hundred children in the following groups: 10-year-olds (25 boys/25 girls) and 13-year-olds (25 boys/25 girls) performed sub maximal treadmill stress test, using modified Balke protocol. All of them went through complex pulmonary function testing and complete anthropometrics measurements, including skinfold thickness. The relative oxygen consumption for the whole group is 38.5 +/- 4.5 mL/min/kg (mean +/- SD). The girls had higher percent fat than boys in both groups (24% vs. 16% in the first group and 27% vs. 18% in the second). With age VO2peak grows parallel with minute ventilation, tidal volume and a tendency towards lowering the breathing frequency is observed irrespective of the sex. We found significant sex differences in ventilatory equivalents for oxygen and carbon dioxide in the second group. VE/VCO2 for the boys decreased from 30.6 +/- 3.1 to 27.6 +/- 2.9; p = 0.002, but remains unchanged in girls. Another interesting fact is that older children rated perceived exertion significantly higher (Borg score 4.6 +/- 0.9 vs. 5.5 +/- 1.4; p < 0.05) despite the standard load. In conclusion there are age and sex differences in some aspects of ventilatory response in pediatric age group.

Adolescent↗
PubMed1999

[The use of bromocryptin--Richter for the suppression of the onset of lactation after the interruption of pregnancy between the 14th and 28th gestational weeks--a preliminary report].

The effect and side reactions of bromocriptin of the firm "Richter" were evaluated in this study. Fifteen women with interrupted pregnancy between 14 and 28 gestational week were explored. To prevent the onset of lactation treatment was started within a few hours after abortion in dosage 2.5 mg (one tablet) twice daily, for 14 days. The prolactin-lowering action began to take effect 2 hours after ingestion of the first tablet, peak after 5 hours, and maintained for 8-12 hours. In course of treatment 14 days in dosage two times daily, the lactation was inhibited in 100% of the cases, in 65% of them she was stopped at the first three days of therapy, in 15% of the cases she was stopped between 3rd and 7th day, and in 20%--after the 7th day of the treatment. The adverse reactions nausea, dizziness, vomiting, diarrhoea, constipation, headache and orthostatic hypotension were transitory. They were observed rarely, and during the first 3-5 days of treatment disappeared.

Abortion, Therapeutic↗
PubMed1999

[Tocolytic treatment of pregnant women with threatened abortions and preterm labor in the second and third trimesters of pregnancy with magne B6 (a preliminary communication)].

The authors check the effect of the substitutional treatment of the pregnant patients with the uterine paints and contractions in the second and third months periods of the pregnancy with "Magne B6"--Sanofi. In the group of the examined patients the Mg deficiency that is the cause for these suffering has been established. After the substitutional treatment with "Magne B6" the described suffering disappeared and clinical-lab values of Mg in the serum and urine normalized.

Abortion, Threatened↗
PubMed1998

[The zinc concentration of the blood serum in women with ovarian tumors (preliminary report)].

The aim of the study is to determine the concentration of blood serum zinc of women with ovarian tumors. The patients included in the study are as follows: 15 women with benign ovarian cysts, 5 with endometrial cysts and 5 with ovarian carcinoma. The control group consists of 157 healthy women whose serum zinc concentration was 13.50 +/- 2.60 mmol/L. We could not demonstrate a significant difference in serum zinc concentration of different groups: benign cysts, endometrial cysts and ovarian carcinoma in comparison control group.

Analysis of Variance↗
PubMed1998

[The concentration of selenium in the maternal serum in cases of missed abortion].

The changes in the serum level of selenium in cases with pathologic pregnancies are still not clear. The aim of the present study was to determine whether serum selenium in cases with missed abortion differed from selenium concentration in serum during first trimester of normal pregnancy. Twenty-three women with missed abortion and 61 with normal pregnancy were included in the study. We found a statistically significant (p < 0.001) elevation of serum selenium level in cases with missed abortion (928 +/- 335 nmol/l) comparing with those with normal pregnancy (568 +/- 77 nmol/l). We discuss the possible mechanisms of the observed changes.

Abortion, Missed↗
PubMed1998

[Multiple pregnancy and microelements: zinc (preliminary report)].

The aim af the study was to define the concentration of zinc in sera of women with multiple pregnancies during the last trimester and to compare it with the values in normal pregnancies. The study included 12 women with gemini and 67 with single fetus pregnancies. A statistically significant decrease was found in the mean zinc concentration in twin pregnancies--8.1 +/- 1.72 mcmol/L compared to the mean values in normal pregnancies--10.5 +/- 1.90 mcmol/L (p < 0.001). Various mechanisms, possibly responsible for the stated changes, their relation to some complications of multiple pregnancy and delivery are discussed, as well as their prophylactics.

Analysis of Variance↗
PubMed1997

[The use of cefotetan for the prevention of infectious postoperative complications in gynecology].

The study presents the results from the use of cefotetan for perioperative prophylaxis in 43 gynaecology patients compared with 29 controls without perioperative antibiotic prophylaxis with similar diseases and operations. Both groups show equal percentage of the cases with smooth postoperative period (70 and 72% respectively). 13 of the patients on cefotetan prophylaxis received additional antibiotic treatment (9 because of temperature up to 37.5 degrees and 4 because of temperature from 37.6 to 38.5 degrees). Mo major infections postoperative complications occurred among the patients on cefotetan prophylaxis. 8 of the non-prophylacted patients needed antibiotic treatment postoperatively including 4 with temperature above 38.5 degrees. Two infections of the operative wounds also occurred in the same group. The conclusion is that cefotetan effectively prevents the major infection postoperative complications in gynaecology. The administration of additional antibiotic treatment is most often not warranted.

Adolescent↗
PubMed1997

[The copper concentration in the maternal serum in missed abortion].

Two groups of women with missed abortion examined in different periods of time were included in the study--the first group of 43 patients was examined in 1989-1990 and the second group of 24 in 1994. The control group consist of 73 women in the first trimester of normal pregnancy and 75 nonpregnant women. The serum copper concentration of the first group with missed abortion (19.47 +/- 4.62 mumol/l) was significantly (p < 0.001) lower than those of control group with normal pregnancy (23.40 +/- 5.10 mumol/l). The serum concentration of the second group with missed abortion was even lower--17.82 +/- 2.95 mumol/l. The serum copper level was measured directly with flame atomic absorption spectrometry. The histology reveals dystrophic and necrotic changes and also inflammatory changes with edema of chorion villi without enhanced collagenisation. We discuss the possible mechanisms of the observed changes.

Abortion, Missed↗
PubMed1996

[Surgical delivery in multiple pregnancy].

During the period 1986-1990, 142 women with multiple pregnancy were treated with the following methods: normal delivery--104 women (73.2%), sectio caesarea--35 women (24.7%), internal versio--2 women (1.4%), forceps operation--1 woman (0.7%). In 81 cases with premature delivery (before 37 week of gestation) was done: normal delivery--64 women (79%), sectio caesarea--15 women (18.5%), internal versio--2 women (2.5%). n 45 cases with unfavourable positions of foetuses it was performed: normal delivery--18 women (40%), sectio caesarea--25 women (55.6%), internal versio-2 women (4.4). (In 10 cases with sectio caesarea and 2 cases with internal versio the indications were prematurity as well as unfavourable positions of the foetuses). The authors consider that it is necessary to increase the operative interventions (sectio caesarea) in cases of multiple pregnancy.

Apgar Score↗
PubMed1996

[The ultrasonic diagnosis of an early abnormal pregnancy].

During the period of January 1993 to February 1994, 70 pregnant women had an ultrasonic diagnosis of abnormal pregnancy. 111 ultrasound examinations were made--mean 1.6 of each woman. The ultrasonic diagnosis up to 70 women was: missed abortion--35 women (50%), blighted ovum--30 women (42.9%), other diagnosis--5 women (7.1%). Histological examination of material was made with 64 women (91.4%). Comparing the ultrasonic diagnosis to histological results, authors do not recommend a final diagnosis before eight gestation week.

Abortion, Missed↗
PubMed1994

[Prolonged pregnancy and trace elements: iron].

Iron is an essential trace element and it is well known that the iron requirement steadily increase during pregnancy. The aim of this investigation was to compare the serum iron levels in normal and serotine pregnancy. Twenty-six women with serotine pregnancy (19 in 42 and 7 in 43 gestation week (g.w.)) were included in the study. The control group is consisted from 74 women with normal pregnancy. The serum iron concentration is elevated in the women with serotine pregnancy (24.59 +/- 11.60 mmol/(l), but the difference was not significant. The group with serotine pregnancy in 42 g.w. has even lower serum iron concentration than the women with normal pregnancy (19.44 +/- 6.52 mmol(l). The serum iron concentration was significantly elevated (p < 0.001) in serotine pregnancy in 43 g.w. compared with normal pregnancy as well as with serotine pregnancy in 43 g.w. The possible pathogenetic mechanisms of the observed changes are discussed.

Analysis of Variance↗
PubMed1993

[The zinc concentration of the maternal serum and the amniotic fluid in pregnancies with fetal neural defects in the second trimester].

The object of the investigation are 120 pregnancies in the second trimester, 38 of which are with prenatally proved neural tube defects of the fetus (anencephaly, spina bifida, hydrocephaly) and 82 with morphologically normal developed fetuses. There have been examined vein blood of the pregnant woman and amniotic fluid after transabdominal amniocentesis as there has been determined zinc status in both of the biological fluids. The average serum's zinc concentration at malformed pregnancies is without statistically considerable difference in comparison with this of the group--healthy pregnancies. Amendable zinc's concentration at cases with neural tube defects are statistical considerably higher than these in the control group. A survey of literary data, devoted to the theory of zinc deficiency as a teratogen in the human pregnancy, has been made during the last years. Up to the author's opinion, there have been represented the most acceptable explanations about the abnormal values of the zinc amenable concentration at neural tube defects in the fetus.

Amniotic Fluid↗
PubMed1992

[The lead concentration of the maternal serum in cases of missed abortion].

The neurotoxic effect of lead is well known, but the investigations of the pregnant women are still few. The aim of the present study is to establish whether there is difference in the concentration of lead in the blood of the pregnant women with missed abortion in comparison with women with normally developing pregnancy in the same gestational age. There were examined 35 patients with missed abortion and a control group of 26 women with normal pregnancy in the same gestational age. There were established statistically significant higher levels of lead (p < 0.001) in women with normal pregnancy (124.46 +/- 46.65 micrograms/l) in comparison with cases with missed abortion (183.73 +/- 24.16 micrograms/l). There were discussed the possible mechanisms, which can be responsible for the observed changes.

Abortion, Missed↗