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Biomedical subjects

B Marek

Publications and source records attributed to B Marek.

48 records · Page 3Linked to original sources
PubMed1996

Circadian variations of salivary melatonin levels in women of reproductive and postmenopausal age with gynoid and android obesity.

Circadian variations of salivary melatonin (MEL) were examined in 81 women (48 of reproductive and 33 of postmenopausal age), 16 of them with moderate overweight, 32 showing gynoid obesity (BMI>30 kg/m[^2]; WHR<0.8) and 33 showing android obesity (BMI>30 kg/m[^2]; WHR>0.8). The circadian profiles of salivary MEL in women with moderate overweight were parallel to those of controls. However, mean 24-h salivary MEL levels tended to be higher in all obese patients as compared with controls (mainly due to increase of its daytime levels). In addition, the suppression of MEL rhythmicity was observed in all subjects studied irrespectively of gynoid or android obesity, while nocturnal MEL peak shift was observed predominantly in the case of extreme obesity with android distribution of adipose tissue. Despite of increasing tendencies mean 24 h MEL concentrations and stronger suppression of circadian variations and/or nocturnal MEL peak shift in extremely obese women with android distribution of adipose tissue, no significant correlation was found between the values of BMI index, WHR ratio and circadian MEL concentrations.

Journal Article↗
PubMed1996

Serum, salivary and urinary cortisol level in the evaluation of adrenocortical function in-patients with bronchial asthma.

56 patients with bronchial asthma (32 women and 24 men) and 31 healthy volunteers (19 women and 12 men) were investigated. The evaluation of the usefulness of salivary and urinary cortisol levels and urinary cortisol metabolites in 24-hr urine was conducted using the correlation coefficient between the cortisol level in the salivary or urine and that in blood serum. Very high correlation was found between the serum and salivary cortisol level (r=0.817). The correlation coefficient between the serum and urinary cortisol level in basal conditions was 0.759, while that between the saliva and urinary level was 0.723. A moderate degree of correlation (r=0.381) was demonstrated between serum cortisol level and 17-OHCS in urine. From these results it was concluded that salivary and urinary free cortisol level estimations may be a useful and non-invasive screening method of evaluating the glucocorticoid function of the adrenal cortex in asthma patients.

Journal Article↗
PubMed1996

[Levels of pituitary-thyroid axis hormones in men during the course of chronic active hepatitis and liver cirrhosis].

Influence of liver pathology on changes in concentrations of individual thyroid hormones, in spite of extensive investigations, remains obscure and the presented opinions are conditionary. The aim of the work was to show whether impairment of liver function (cirrhosis, chronic active hepatitis CAH) affects basic concentrations of TT3, TT4, fT3, fT4 and TSH. The investigations were carried out in 30 males (mean age 51.8 years) with cirrhosis of the liver and in 30 males (mean age 38.9 years) with CAH. The diagnosis was established on the basis of the clinical picture, results of biochemical and serological blood tests, as well as on histopathological examination of liver samples. The control group consisted of 20 male healthy volunteers. Fasting blood samples were collected between 7 and 8 a.m. Concentrations of TT3, TT4, fT3, fT4 and TSH were estimated with the RIA method. A significant decline of TT3, TT4, fT3, fT4 concentration and TT3/TT4 index in males with liver cirrhosis were observed.

Adult↗
PubMed1993

[Activities of certain endocrine glands in bronchial asthma].

The present reports on the effects of various levels of the endocrine system on the course of bronchial asthma are reviewed. Hypophyseal function in production of certain hormone and functioning of the hypothalamo, hypophyseal-thyroid, -adrenal, and -gonadal axis are discussed. Changes in the functions of endocrine glands may modify the course of allergic diseases.

Asthma↗
PubMed1992

[Prostaglandins PGF2alpha in the fight against bleeding and hemorrhage the uterus during the climacteric period].

This article is about usage prostaglandins to fight against bleeding and haemorrhage from uterus in climacteric period. Prostaglandins are used widely by gynecologist and obstetrics as most powerful contracting drugs, namely in this situations when we observe returning, plentiful bleeding from uterus. Women with climacteric bleeding had administer prostaglandins intravenous or immediate intra-cervix. They are very good drug, strongly and a long time hold up bleeding. This method give us time to better preparing patients to operation and diminish losses of blood. Side effects are small and not trouble. Prostaglandins are very simply in usage and characterise very good haemostatic effect, recognised faster then in typical methods like hormonal, mechanical antifibrinolytic etc.

Climacteric↗
PubMed1991

Circadian variations of serum triiodothyronine, thyroxine, corticosterone and lipids in starved rats.

Circadian variation of serum triiodothyronine (T3), thyroxine (T4), corticosterone (B) and lipids was studied in male Wistar rats after one week of the starvation. The animals were adopted to 12:12 h light-dark cycle (lights on from 7.00 to 19.00 h) and tap water was available ad libitum. Blood samples were drawn at 3 h intervals along a 24 h span. The hormone levels were measured by RIA kits, plasma lipids by photometric method. The results were evaluated by cosinor method. The presence of a circadian rhythm of T3 and B was found in control rats. The starvation resulted in changed circadian rhythm of T3 with lower values of mesor and amplitude, and while acrophase shifted from 14.48 to 2.12. In addition, the starvation induced circadian rhythm of T4 with acrophase at 1.00. The circadian rhythm of B showed significantly higher values of mesor and amplitude, while acrophase shifted from 17.42 to 4.06. The concentration of lipids was changed in the animals deprived of food as compared with controls.

Animals↗
PubMed1989

[Usefulness of measuring the levels of estrogens and progesterone in the saliva during pregnancy].

In recent years there have appeared reports on the usefulness of marking steroid hormones in the saliva to evaluate the function of ovaries and degree of threat to pregnancy. Many authors studied the correlation between the concentration of estrogens and progesterone in the blood and saliva both in physiological and pathological pregnancy. It was found that the concentration of steroids in the saliva reflects free steroids circulating in the blood, not bound with proteins, marking of which supplies more reliable clinical information. Opinions on determining hormones in the saliva and their importance in monitoring fetal-placental unit are controversial. On the other hand, availability, non-invasiveness and easiness of collecting saliva increases an interest in this biological material.

Estrogens↗
PubMedDate not supplied

Homocysteine, vitamin B12, and folic acid in age-related macular degeneration.

PURPOSE: Hyperhomocysteinemia is considered an independent risk factor for atherosclerosis and thrombosis. The purpose of this study was to evaluate plasma homocysteine, red blood cell folate, plasma folate, and plasma vitamin B12 concentration in patients with exudative age-related macular degeneration (ARMD). METHODS: The participants of this study included 30 patients aged 60 to 71 years (mean age 66.2+/-3.6) with exudative ARMD. Plasma homocysteine levels were determined by high performance liquid chromatography (HPLC). Red blood cell folate, plasma folate, and plasma vitamin B12 concentration were determined using a standard kit (Dualcount Solid Phase No Boill radioassay kit for B12/folic acid, DPC Diagnostic, USA) by radioassay method. RESULTS: The plasma concentration of Hcy (14.88+/-6.23 micromol/L) in ARMD patients was significantly increased (p<0.0001) compared with the control group (8.72+/-3.34 micromol/L). We found not a significant decrease of the plasma vitamin B12 concentration in the ARMD group (476.88+/-220.91 pg/mL) compared with the control group (527.08+/-208.97 pg/mL). Red blood cell folate (158.44+/-56.30 ng/mL) and plasma folate (6.5+/-3.4 ng/mL) in ARMD patients were also not significantly decreased when compared with the control group (183.86+/-59.33 ng/mL and 7.93+/-5.05 ng/mL). CONCLUSIONS: Hyperhomocysteinemia might be one of the risk factors for the exudative form of ARMD.

Aged↗
PubMedDate not supplied

[Thyrotoxic periodic paralysis].

A 25-year-old male with hyperthyroidism had in the first week of treatment signs of thyreotoxic periodic paralysis with very low potassium level (2.16 mmol/ml) and fivefold increase in serum myoglobin level (600 ng/ml) indicating damage to muscle fibres undetectable in EMG examination. The clinical symptoms regressed after intravenous administration of potassium.

Adult↗