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Biomedical subjects

B Mamoli

Publications and source records attributed to B Mamoli.

142 records · Page 8Linked to original sources
PubMed1975

[Subacute myelo-optic-neuropathy (S.M.O.N.) following treatment with clioquinol (author's transl)].

2 patients, who were treated with clioquinol after radical resection of carcinoma of the rectum and colostomy, developed symmetrical sensorimotor polyneuropathy, mild posterior tract ataxia, bilateral pyramidal tract lesions and optic neuropathy, a clinical picture compatible with subacute myelo-optic-neuropathy (S.M.O.N.). One patient had neurological symptoms after having received 750 g of clioquinol, 3 years after treatment started, and impairment of vision was noted after having received 1200 g. The other patient had neurological symptoms 6 weeks after clioquinol was first given, having received 65 g, the average daily dose being 1.5 g, and vision was impaired after 765 g had been administered. On examination 12 and 14 months after clioquinol had been discontinued, the first patient's vision was slightly improved, but he was otherwise unchanged, while the vision of the other patient was unchanged, but she had otherwise deteriorated slightly neurologically. Electrophysiological examinations confirmed the clinical observations. A multifactor etiology of the syndrome: neurotoxicity of clioquinol, paraneoplastic neuropathy and malabsorption, is discussed.

Abdomen, Acute↗
PubMed1975

[Long-term EEG investigations at the withdrawal of young polytoxicomanic addicts].

Serial EEG examinations (an average of three recordings in 14 weeks) are reported from adolescent inpatients (19 in number) who had been weaned of multiple drug abuse of an average duration of 2 years. At first examination seven had a normal EEG, 11 had a moderately abnormal EEG, and one had a markedly abnormal one. At final examination 13 had a normal EEG, five had a moderately abnormal EEG and three had definitely abnormal EEG's. The majority of the patients showed a decrease (significant at the 5% level), others an increase in EEG abnormalities. The relationship between the EEG changes in the course of the series on the one hand and the previous drug abuses is discussed.

Adolescent↗
PubMed1975

[Electrophysiological studies on the prognosis in idiopathic facial paralysis].

The literature on electrophysiological techniques used so far for the prognostication of idiopathic facial palsies contains reports on 31 patients with idiopathic facial palsy, in whom - after electric stimulation of the nervus facialis at the point where it exits from the foramen stylomastoideum - the amplitude of the compound muscle action potential of the M. orbicularis oris was measured. The extent of the SPA's decline was related to the progress of the disease. In those cases where the SPA declined by at least 75-100 per cent, the palsy regressed either in an unsatisfactory manner or not at all. However, where the decline amounted to at most 67 per cent a restitutio ad integrum took place or residual symptoms which do not disturb the patients were found. The prognosis can be made between the 5th and 10th day after the palsy has developed. If in cases of idiopathic palsy the diagnosis is made at an early date, this method is more reliable than any other technique.

Action Potentials↗
PubMedDate not supplied

Pleural and bone marrow metastasis from supratentorial oligoastrocytoma grade III.

We report a 62-year-old man with symptomatic metastasis to the pleural cavity and the bone marrow from a supratentorial oligoastrocytoma grade III, 24 years after the initial symptoms. Before tumor dissemination, the patient underwent brain surgery four times in 5 years. Six months after the last treatment, extraneural dissemination to the right pleural cavity was discovered. Despite resection of the pleural metastasis, local and distant spread to the bone marrow developed. The patient died 5 months after the occurrence of extraneural tumor metastasis. It is speculated that repeated brain surgery and extended survival may promote extraneural dissemination of supratentorial oligoastrocytoma grade III.

Astrocytoma↗
PubMedDate not supplied

Prevalence of multiple sclerosis in Austria. Results of a nationwide survey.

The epidemiology of multiple sclerosis (MS) in Austria is almost unknown. We evaluated the prevalence of MS in Austria using data from questionnaires completed by neurologists, comprising information on a total of 1,006 MS patients who attended 30 out-patient specialized clinics nationwide. Additional data were collected from 2,414 MS patients, who received questionnaires from the Austrian MS Society or their doctor. A novel extrapolation model, based on frequencies of patients visits at MS clinics, was used to estimate the overall prevalence of MS. Considering either disability or the course of the disease, the prevalence of MS patients in Austria was estimated to be 98.5 per 100,000 people. The prevalence of MS in Austria was found to be similar to that of other countries in Central Europe. Epidemiological studies, such as this, provide a unique source of data from which key features of a disease and its impact on patients may be examined.

Adult↗
PubMedDate not supplied

Immunoglobulins in acute, parainfectious, disseminated encephalo-myelitis.

Acute, parainfectious, disseminated encephalo-myelitis (ADEM) is usually treated with corticosteroids. Intravenous immunoglobulins have not been applied to patients with ADEM. This article describes a 22-year old woman who developed progressive paraparesis, ascending sensory dysfunction, and urinary incontinence one week after tonsillitis. Guillain-Barré syndrome was diagnosed initially, and intravenous immunoglobulins (0.4 g/kg daily) were begun. Symptoms deteriorated after the first and second applications, but after the third application the patient's sensory level declined. After the fourth application, the deterioration of symptoms stopped and cerebrospinal fluid (CSF) abnormalities improved. Because of diffuse spinal cord swelling, intramedullary edema, and hyperintense white and grey matter lesions in the basal ganglia and the corpus callosum on MRI scans, the diagnosis was corrected to ADEM. It is concluded that initial administration of intravenous immunoglobulins might be of therapeutic value in patients with ADEM.

Adult↗
PubMedDate not supplied

Cerebrospinal fluid filtration and immunoglobulins in multifocal motor neuropathy.

Cerebrospinal fluid (CSF) filtration has been shown to be of benefit in chronic inflammatory, demyelinating polyneuropathy, but has not been applied to multifocal motor neuropathy (MMN) so far. Twenty-seven months after a 48-year-old male patient had developed slowly progressive, distally prominent monoparesis of the left arm, MMN was diagnosed. Conduction blocks were found in the left brachial plexus after median, ulnar, and radial nerve stimulation. Serum anti-GM1 antibody titers were markedly increased. Biopsy of the motor long thoracic nerve showed reduction of small caliber myelinated axons and irregularly shaped myelin lamellae. Treatment with immunoglobulins 29, 31, 36, and 39 months after onset was followed by a distinct improvement each time. Thirty-four months after onset, one liter CSF was filtered off by means of a bidirectional syringe pump with only minor therapeutic effect. In conclusion, immunoglobulins had a stronger therapeutic effect than CSF filtration on the MMN patient described.

Case-Control Studies↗