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Biomedical subjects

B Mamoli

Publications and source records attributed to B Mamoli.

At least 109 records · Page 6Linked to original sources
PubMed1980

[Correlation between clinical and angiographic findings in cases of transient cerebral circulatory disturbances (author's transl)].

The results are presented of angiographic investigations in 85 patients suffering from transient ischaemic cerebral circulatory disturbances. Transient ischaemic attacks (TIA) were observed in 45 patients, reversible ischaemic neurological defects of longer duration (PRIND) were diagnosed in 40 patients. The mean age of all patients at the time of angiography was 49.9 years. Transfemoral cerebral panarteriography was performed in all cases, including studies both of the aortic arch and of the cranio-cervical vessels. The mean interval between the first manifestation of cerebrovascular disease and angiographic investigation was approximately 2 years. 10.6% of all patients showed normal angiograms; in 35.3% of all cases diffuse vessel wall alterations were found; 37.6% showed minor stenoses (vessel diameter reduced to 80-34%), whilst 16.5% showed major stenoses (vessel diameter reduced to 33-1%) or occlusions. There was poor correlation between clinical-neurological localization of the ischaemic lesion and the angiographically-verified stenoses or occlusions. The angiographic findings corresponded to the clinically affected regions in only 52.2% of all patients suffering from stenoses of occlusions. A good correlation was found in 71.4% of the cases when only major stenoses and occlusions were evaluated. Consequently, angiographic studies of the aortic arch, as well as of all extra- and intracranial vessels are a precondition for the surgical treatment of the cranio-cervical vessels in every patient. It is possible by these means only to achieve a comprehensive assessment of the haemodynamic processes in the cerebral circulation.

Adolescent↗
PubMed1980

Purine metabolism of erythrocytes in myotonic dystrophy.

The uptake and subsequent metabolism of adenine and adenosine was studied with the intact erythrocytes of patients with myotonic dystrophy (MD). Washed erythrocytes of both controls and patients were incubated with 14C-labeled adenine or adenosine at 20 degrees C for 5 to 120s to characterize the uptake process. No differences in the uptake process of adenine or adenosine were observed between normal and MD erythrocytes. Formation of adenine nucleotides was determined at 37 degrees C after incubation for 30 min. Compared to controls, the incorporation of adenine into adenine nucleotides was 2.6 times higher in MD erythrocytes. This depends mainly on an increase of ATP formation. The mean ratios of ATP:ADP + AMP for normal red cells and MD erythrocytes were 0.92 and 1.39 respectively. No difference was found in the conversion of adenosine to adenine nucleotides. In spite of a normal amount of intracellular ATP a greater demand for ATP exists. This might be due to leakage of adenine nucleotides out of MD erythrocytes.

Adenine↗
PubMed1980

[Electrophysiologic investigations in a family with malignant hyperthermia (author's transl)].

The value of the quantitative electromyogram in the detection of subclinical myopathic signs was tested in a family consisting of 11 members, one of them showing a Malignant Hyperthermia crisis. Furtheron an in vitro contracture test and an ATP-test was performed and the Serum CPK and the isoenzyme in serum and muscle examined. The following conclusions were taken: 1) Although unspecific pattern (in 5 cases more than 12% polyphasic potentials were found, one of them showing a reduction of the mean duration of 30%) the electromyography is a good but not absolutely certain indicator of subclinical myopathic signs in Malignant Hyperthermia. 2) The exclusion of M.H. risk is not possible using a single test. 3) The diagnostic value of not invasive methods, as the electromyography is of special importance. The diagnostic use of many M.H. tests seems necessary.

Adolescent↗
PubMed1980

Effects of cerebral gangliosides in the alcoholic polyneuropathies.

In chronic alcoholic patients with a slight or moderate polyneuropathy the effect of gangliosides at a daily dosage of 20 mg was investigated. A clinical improvement represented by a reappearance of the Achilles reflex and/or marked reduction of hypoaesthesia was found in the treated group. No significant changes in motor function were observed. No significant variation of the electrophysiological examination was found.

Action Potentials↗
PubMed1980

[Placebo-controlled EEG-double blind study with the further purified TBE-vaccine (author's transl)].

In a placebo-controlled double blind study at random with 72 healthy persons the effect of an active TBE-vaccination (purified TBE vaccine) on EEG was investigated. 49 out of 72 examined persons could be examined twice, before and 3 to 5 days after vaccination respectively. The EEG was registered according to the international 10-20 electrode system in bipolar, unipolar and source derivations, using a 16 channel Elema-Schoenander electroencephalograph. The registration was made at rest, with hyperventilation and photo-stimulation. The EEG was registered on a tape-recorder and, using a computer, an automatic analysis (Fourier-Analysis) of the CZ-O2 derivations was performed, in order to get more exact results and a quantification of the basic-rhythmus. The visual evaluation and automatic analysis showed no significant changes of the EEG after TBE vaccination. There results were statistically determined by T-Tests and by discriminance analysis.

Adolescent↗
PubMed1980

[Electrophysiological studies in vincristin-polyneuropathy (author's transl)].

21 Patients with malignant brain tumors were treated with vincristine (1,4 mg/m2) in the course of combination chemotherapie, given in 14 days series over 3 months up to 26 month. 18 patients developed clinical signs of a sensory and 4 patients of a sensomotoric polyneuropathy. Changes in nerve conduction velocity of the N. peronaeus and N. suralis and amplitude of the evoked muscle response (M. extensor digitorum brevis) and nerve action potential were studied in dependency of the total vincristine dosage. The following conclusions were drawn. 1. Clinical occurrence of vincristine polyneuropathy and decrease of nerve conduction velocity of peroneal and sural nerve and the amplitude of the muscle response and nerve action potential are dosage dependent. 2. Sensory fibres appear to be damaged earlier and more severe than motor fibers, but this difference was statistically not significant. 3. Nerve conduction velocity of peroneal and sural nerve is normal or slightly decreased in vincristine polyneuropathy, but the amplitude of the evoked response in extensor digitorum brevis muscle and of the nerve action potential of the suralis nerve are markedly diminished. This result indicates that vincristine polyneuropathy is of primary axonal orgin. 4. If vincristine dosage is reduced to half or vincristine is discontinued after a reduction of the potential amplitude in the extensor digitorum brevis muscle below 1 mV, severe, not reversible polyneuropathies may be avoided.

Action Potentials↗
PubMed1980

[Clinical experience with daily doses of misonidazole (author's transl)].

In this pilot study daily low doses of misonidazole (in the range of 1 to 2 g) up to cumulative doses between 7 and 19 g/m2 were used. Serum levels were analysed at different times after administration and according to several dose regimens. We related the cumulative doses to the incidence and severity of the observed peripheral neuropathies. The aim was to find an effective daily low-dose schedule of misonidazole with a clinically acceptable incidence of side effects. Some impressive clinical responses were observed.

Adult↗
PubMed1980

[Childhood hand surgery according to neurological and electrophysiological assessment (author's transl)].

The importance of close collaboration between the plastic surgeon and the neurologist who is interested in electrophysiological techniques is particularly important in children. Collaboration of the patient may be limited. Electromyographical and electroneurographic investigations may localise the lesion and be relevant to giving a prognosis. The various methods and limitations are briefly discussed.

Child↗
PubMed1979

EEG, pattern-evoked potentials and nerve conduction velocity in a family with adrenoleucodystrophy.

In a family with 8 children one case of adrenoleucodystrophy (ALD), verified by autopsy, 2 cases with clinical signs of ALD and four other clinically healthy subjects with pathological ACTH tests were found. As an initial sign in the EEG, temporo-occipital slowing occurred. Further EEG studies showed spread of the primary local abnormalities, indicating diffuse brain dysfunction during progression of the disease. Terminal EEG flattening may be characteristic for late stages of the disease. No correlation could be established between lateralization, paroxysms and actual stage of the disease. Abnormal EEGs occurred not only in clinically and subclinically affected male patients, but also in a girl, who might be a carrier of ALD. Visual evoked potentials showed an increased latency of the P2 wave in the clinically, and in one subclinically, affected subjects. Motor nerve conduction velocity was reduced in only 2 patients. Antidromic sensory nerve conduction velocity of the median nerve was normal in all patients.

Addison Disease↗
PubMed1979

Electroneurographic investigations of misonidazole polyneuropathy.

13 patients with malignant tumors were treated by the radiosensitizer misonidazole (Ro 07-0582), total dosage 20-29 g. The electrophysiological investigations showed (1) an early increase of distal latency, the motor nerve conduction velocity (NCV) of the peroneal nerve and the NCV of the sural nerve remaining normal or only signlty reduced, and in a few cases a marked reduction of the compound action potential or of the nerve action potential (NAP), indicating a primary axonal neuropathy; (2) greater changes in the parameters of sensory nerves (n. suralis) than of motor nerves; (3) the distal latency is a good indicator of subclinical neuropathies; (4) the electrophysiological parameters showed a normalization 6 months after the end of therapy. The mechanisms possibly responsible for the misonidazole neuropathy are discussed.

Action Potentials↗
PubMed1978

Further clinical experiences of a phase I study with the hypoxic cell radiosensitizer misonidazole.

Since April 1976 we have performed clinical investigations with multiple doses of the hypoxic cell radiosensitizer misonidazole in 21 patients. A significant side effect of the drug was the development of peripheral sensory neuropathies in 13 patients (8 mild, 5 severe) and of a transient acute organic psychosyndrome in 2 of the 5 patients with a severe polyneuropathy. The severity of the polyneuropathies is related to the total dose of misonidazole and the overall time of drug administration. Treatment schedules designed to obtain the desired sensitizing effect without neurological side effects are under investigation.

Adolescent↗