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Biomedical subjects

B Maldague

Publications and source records attributed to B Maldague.

At least 109 records · Page 6Linked to original sources
PubMed1975

Detection of skeletal involvement in Hodgkin's disease: a comparison of radiography, bone scanning and bone marrow biopsy in 38 patients.

As part of the staging of 38 patients with Hodgkin's disease seen over an 18-month period, we have used radioisotopic scanning of bone, as well as radiography and bone marrow biopsy, in an attempt to assess osseous and bone marrow involvement. Of the 38 patients, 14 were found to have skeletal involvement. In 11 this was histologically proved. In 8 patients, the radioisotopic scan first raised the suspicion of localized bone involvement, which was subsequently proved by bone marrow biopsy or by radiography. We believe that bone marrow involvement may at times be localized when patients with Hodgkin's disease are first staged and may precede local osseous involvement. If this is so, a reasonable approach to the search for bone marrow or osseous involvement would be to start with a bone scan and to follow this with a bone marrow biopsy from the suspicious area or a careful radiography of the same site; the latter is important if the site of increased uptake of the radionuclide is inaccessible to the biopsy needle.

Adolescent↗
PubMedDate not supplied

Apparent focal bone marrow ischemia in patients with marrow disorders: MR studies.

OBJECTIVE: We sought to assess with MR the focal bone marrow abnormalities in patients with chronic marrow disorders and acute limb pain. MATERIALS AND METHODS: We investigated and followed with MRI four patients with proliferative or dysplastic marrow disorders presenting with acute but spontaneously resolving hip or thigh pain. RESULTS: Ten focal marrow lesions were demonstrated on T2-weighted images as high signal intensity (SI) areas. They remained undetected on T1-weighted images as they showed a low SI similar to the disease-related low SI of the entire marrow. Postcontrast images demonstrated lack of enhancement in the lesions. Follow-up enhanced MR images showed intense enhancement within the lesions, while unenhanced MR images remained unchanged. Later on, these focal marrow abnormalities completely resolved. These lesions most likely represent bone marrow ischemia, although histological proof is lacking. CONCLUSION: Acute bone pain in patients with bone marrow disorders may be related to focal marrow lesions suggestive of bone marrow ischemia.

Bone Marrow↗
PubMedDate not supplied

[Ankylosing spondylarthritis and partial cauda equina syndrome. Apropos of 4 cases and review of the literature].

Four new cases of ankylosing spondylitis complicated by a cauda equina syndrome are reported. Similarly to the previous descriptions, the patients present with long-standing and severe spondylitis at the time when neurological symptoms, mainly radicular pain, develop. Computed tomography of the lumbar spine demonstrates in all cases typical laminar erosions and posterior arachnoid diverticula. Up to now, magnetic resonance imaging has rarely been performed in this particular pathology, though it is helpful in determining the anatomical relations and the nature of the lesions. Based on the previous publications, our study aims at describing the clinical and pathogenic aspects of the disease and defining the most useful diagnostic investigations and treatment choices. Therapeutic possibilities are often limited because of a late diagnosis. Better knowledge of this rare complication could lead to earlier recognition and more efficient therapy.

Aged↗