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Biomedical subjects

B Make

Publications and source records attributed to B Make.

17 recordsLinked to original sources
PubMed2004

Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD.

The aim of this study was to test the hypothesis that use of tiotropium, a new long-acting anticholinergic bronchodilator, would be associated with sustained reduction in lung hyperinflation and, thereby, would improve exertional dyspnoea and exercise performance in patients with chronic obstructive pulmonary disease. A randomised, double-blind, placebo-controlled, parallel-group study was conducted in 187 patients (forced expiratory volume in one second 44 +/- 13% pred): 96 patients received 18 microg tiotropium and 91 patients received placebo once daily for 42 days. Spirometry, plethysmographic lung volumes, cycle exercise endurance and exertional dyspnoea intensity at 75% of each patient's maximal work capacity were compared. On day 42, the use of tiotropium was associated with the following effects at pre-dose and post-dose measurements as compared to placebo: vital capacity and inspiratory capacity (IC) increased, with inverse decreases in residual volume and functional residual capacity. Tiotropium increased post-dose exercise endurance time by 105 +/- 40 s (21%) as compared to placebo on day 42. At a standardised time near end-exercise (isotime), IC, tidal volume and minute ventilation all increased, whilst dyspnoea decreased by 0.9 +/- 0.3 Borg scale units. In conclusion, the use of tiotropium was associated with sustained reductions of lung hyperinflation at rest and during exercise. Resultant increases in inspiratory capacity permitted greater expansion of tidal volume and contributed to improvements in both exertional dyspnoea and exercise endurance.

Aged↗
PubMed1998

Acute exacerbations of chronic bronchitis: an international comparison.

The prevalence of chronic bronchitis is between 3% and 17% in most developed countries. However, higher rates in the range of 13 to 27% are encountered in less developed areas of the world. Acute exacerbations of chronic bronchitis (AECB) have usually been defined as the presence of increases in cough/sputum, sputum purulence, and dyspnea. However, recent investigations suggest that the severity of AECB may be divided into three stages based on the history of the patient: (1) previously healthy individuals; (2) patients with chronic cough and sputum and infrequent exacerbations; and (3) persons with frequent exacerbations or more severe chronic airflow limitation. Therapy for patients with less severe AECB include older and less expensive broad-spectrum antibiotics, while newer agents are indicated for patients with the most severe stage of AECB.

Anti-Bacterial Agents↗
PubMed1995

Quantitative chest computed tomography as a means of predicting exercise performance in severe emphysema.

RATIONALE AND OBJECTIVES: We assessed the value of quantitative high-resolution computed tomography (CT) as a diagnostic and prognostic tool in smoking-related emphysema. METHODS: We performed an inception cohort study of 14 patients referred with emphysema. The diagnosis of emphysema was based on a compatible history, physical examination, chest radiograph, CT scan of the lung, and pulmonary physiologic evaluation. RESULTS: As a group, those who underwent exercise testing were hyperinflated (percentage predicted total lung capacity +/- standard error of the mean = 133 +/- 9%), and there was evidence of air trapping (percentage predicted respiratory volume = 318 +/- 31%) and airflow limitation (forced expiratory volume in 1 sec [FEV1] = 40 +/- 7%). The exercise performance of the group was severely limited (maximum achievable workload = 43 +/- 6%) and was characterized by prominent ventilatory, gas exchange, and pulmonary vascular abnormalities. The quantitative CT index was markedly elevated in all patients (76 +/- 9; n = 14; normal < 4). There were correlations between this quantitative CT index and measures of airflow limitation (FEV1 r2 = .34, p = 09; FEV1/forced vital capacity r2 = .46, p = .04) and between maximum workload achieved (r2 = .93, p = .0001) and maximum oxygen utilization (r2 = .83, p = .0007). CONCLUSION: Quantitative chest CT assessment of disease severity is correlated with the degree of airflow limitation and exercise impairment in pulmonary emphysema.

Aged↗
PubMed1994

Collaborative self-management strategies for patients with respiratory disease.

The effectiveness of collaborative self-management of respiratory disorders has been most clearly demonstrated in asthma. In both adults and children with severe asthma requiring emergency care and hospitalizations, collaborative self-management can decrease not only the need for emergency care and hospitalization but also time lost from work and school, thereby increasing the patients' ability to be full and active participants in the community. Collaborative self-management is best provided in a comprehensive program that includes ready access to healthcare professionals, education, behavioral therapy, and peak-flow monitoring. The relative value of each of these components and the value of single components applied simultaneously is unclear. In some studies, asthma symptoms and medication adherence have also improved following implementation of collaborative self-management. The available data indicate that collaborative self-management should be considered as a potential therapeutic adjunct in the management of every patient with asthma and should be routinely employed with patients who have severe disease as defined by emergency room use and hospitalizations. Additional investigations should be conducted in patients with other respiratory diseases to define the role of collaborative self-management. Nonetheless, state-of-the-art medical care and the nature of the patient-physician relationship in the 1990s dictates that collaborative self-management be routinely employed in the optimal outpatient management of any individual who is interested in participating in his or her own healthcare. However, individualization of the practitioner-patient relationship is necessary. Not all patients desire to play an active role in their illness and its management. The personality, attitudes, and desires of individuals in assisting in their own management must be assessed. Theory would suggest that patients who do not appear to have an interest in self-management may have low self-efficacy that may be increased by educational efforts. Improved self-efficacy and active participation in disease management may result in beneficial outcomes. It is clear that the physician-patient relationship has changed over the past decade. As patients have been empowered to act in their own best interests, the physician's role as an educator and facilitator has become more prominent than ever. Even if medical investigations had not demonstrated any beneficial effects of collaborative self-management, patients have the right to participate in decisions affecting their healthcare and are increasingly exercising that right. Respiratory care practitioners are in a unique position to enhance collaborative self-management. In the home environment, RCPs can foster smoking cessation and serve as a liaison between patients and physicians.(ABSTRACT TRUNCATED AT 400 WORDS)

Adolescent↗
PubMed1991

COPD: management and rehabilitation.

Chronic obstructive pulmonary diseases include emphysema, chronic bronchitis and asthma. Patients with mild disease may remain asymptomatic for many years. In patients with a sedentary lifestyle, 60 percent of lung function may be lost before shortness of breath occurs during daily activity. Spirometry may detect mild to moderate airflow obstruction in asymptomatic patients. Goals of therapy include reduction of airflow obstruction, prevention or treatment of complications, and improvement in quality of life.

Bronchodilator Agents↗
PubMed1989

Controlled trial of external negative pressure ventilation in patients with severe chronic airflow obstruction.

The effect of intermittent external negative pressure ventilation (ENPV) with the Emerson Pulmowrap ventilator upon leg cycle endurance time (ET), maximal transdiaphragmatic pressure (Pdimax), breathing pattern as expressed by the tension time index (TTdi), and sense of well being was studied in 16 patients with severe chronic airflow obstruction (CAO). The patients were randomized to 3 wk of in-hospital pulmonary rehabilitation (Group I, seven patients) or the same program plus ENPV (Group II, nine patients). Both groups were similar in terms of age (65 +/- 8 versus 61 +/- 13 yr), severity of CAO (FEV1 of 0.64 +/- 0.14 versus 0.59 +/- 0.18 L), and PaCO2 (44 +/- 9 versus 45 +/- 7 mm Hg). Blood theophylline levels and nutritional status were also similar in both groups. Baseline ET (2.9 +/- 0.6 versus 3.8 +/- 1.6 min) and Pdimax (45 +/- 15 versus 56 +/- 18 cm H2O) were decreased in both groups. Baseline TTdi was high but similar in both groups; at rest the values were 0.15 +/- 0.05 versus 0.16 +/- 0.04, and at end-exercise they were 0.17 +/- 0.06 versus 0.21 +/- 0.12. After treatment FEV1 and Pdimax remained unchanged, but the patients in both groups manifested clinical improvement and had a significant increase in mean ET (Group I from 2.9 to 6.9 and Group II from 3.8 to 6 min, p less than 0.01). TTdi decreased both at rest (0.14 +/- 0.07 versus 0.13 +/- 0.04) and at end-exercise (0.14 +/- 0.06 versus 0.15 +/- 0.09) with no difference between groups.(ABSTRACT TRUNCATED AT 250 WORDS)

Airway Obstruction↗
PubMed1987

Respiratory muscle dysfunction secondary to chronic tracheostomy tube placement.

In patients requiring periodic mechanical ventilation, a deflated, fenestrated tracheostomy tube may impair respiratory muscle performance during spontaneous breathing. We describe a patient with severe chronic airflow obstruction (CAO) whose respiratory muscle performance and exercise duration improved after tracheostomy tube removal. Duty cycle, Pdi/Pdi max, and the tension time index were all lower during exercise after tracheostomy tube removal. We conclude that a deflated and fenestrated tracheostomy tube significantly increases airways resistance and can further limit ventilatory muscle performance in patients with airflow obstruction. Patients requiring intermittent ventilatory support may benefit from permanent tracheostomy fistulas that allow for intermittent self cannulation. This would avoid loading of the respiratory muscles when breathing spontaneously.

Airway Obstruction↗
PubMed1985

Respiratory consequences of abdominal hernia in a patient with severe chronic obstructive pulmonary disease.

The diaphragm is the most important muscle of respiration. It is believed that the abdominal contents affect diaphragmatic contraction by helping determine its length tension state and by acting as a fulcrum for this muscle to lift the rib cage and thereby increase lung volume. In support of these concepts we describe a patient with severe chronic obstructive pulmonary disease and a large midline hernia of the abdomen who, when standing, had a gastric pressure (Pg) of 4 cm H2O and a maximal transdiaphragmatic pressure (Pdimax) of 14 cm H2O. This was associated with an O2 saturation of 82%, lower thoracic and upper abdominal paradoxical breathing, and severe dyspnea. Once the hernia was reduced there was a rise in Pg to 12 cm H2O, of Pdimax to 27 cm H2O, and of O2 saturation to 89%. There was normalization of the breathing pattern and a decrease in dyspnea. Reduction of this patient's abdominal hernia resulted in an increase in her exercise tolerance.

Abdomen↗
PubMed1985

Physiologic closure of a symptomatic patent foramen ovale with oxygen therapy.

Surgery is required for correction of a physiologically significant patent foramen ovale. We report a patient with poliomyelitis and respiratory failure in whom a patent foramen ovale became symptomatic because of hypoxemia-induced pulmonary hypertension. Oxygen therapy and mechanical ventilation reversed the pulmonary hypertension, resulting in physiologic termination of the patent foramen ovale without surgery.

Aged↗
PubMed1984

Rehabilitation of ventilator-dependent subjects with lung diseases. The concept and initial experience.

Sixteen ventilator-dependent patients were enrolled in an in-patient pulmonary rehabilitation (PR) program in a university medical center with the goals of achieving independent self-care, mobility and discharge home. Ten patients had chronic obstructive pulmonary disease and six had restrictive respiratory disorders. PR by a multi-disciplinary team consisted of five phases: 1) stabilization; 2) evaluation; 3) rehabilitation planning including motivation by allowing speech and mobility; 4) rehabilitation training encouraging independent performance of activities of daily living (ADL); and 5) discharge planning with training of patients and families in home respiratory care techniques. A key aspect of the program is improving independence early in the program through the use of mobile ventilators. Periods of weaning from ventilatory support for two or more hours per day were of great importance in improving patient mobility and independence in ADL. Twelve patients were discharged home; except for two individuals who were severely limited by neuromuscular disease, all patients were largely independent in ADL in the home. This preliminary report demonstrates the feasibility of training ventilator-dependent persons to be independent and to participate in their own care in the home.

Activities of Daily Living↗
PubMed1983

Home care of the ventilator-dependent person.

Discharge of the ventilator-dependent person from a hospital requires careful advance planning by hospital personnel and rehabilitation of the patient to assure maximal functional ability in the home. The patient and family should be taught the techniques necessary for both routine and emergency care in the home. Respiratory equipment, including the type of mechanical ventilator best suited to the patient's needs and the home environment, and disposable supplies must be obtained, and payment from third-party payers must be assured. Equipment placement and the ability of the patient to perform self-care and activities of daily living following discharge can be facilitated by integrating results of a home care evaluation into the patient's rehabilitation program. Trips of gradually longer duration out of the hospital allow the patient to gain confidence in his ability to care for himself. Responsibilities for follow-up in the home can be shared by respiratory home care companies, visiting nurses, and pulmonary physicians.

Boston↗
PubMed1978

Diagnosis and management of hypoxemia.

The following steps are necessary in the successful management of hypoxia: 1. Establish the presence of hypoxemia with measurements of arterial blood gases. 2. Search for signs of tissue hypoxia. 3. Assign a physiologic cause for hypoxemia. 4. Begin oxygen therapy by a method appropriate to underlying pathophysiologic mechanism, as outlined in Table 2. 5. Repeat arterial blood gas measurements to assure adequate reversal of hypoxemia. 6. Treat any underlying disease(s).

Humans↗
PubMed1975

Factors influencing the measurement of closing volume.

The various factors influencing closing volume were studied by performing the single-breath N2 test on 9 healthy nonsmokers. Time of day, day of the week, and preceding volume history had no effect on either closing volume or alveolar plateau. Slow inspiratory flow resulted in larger ratio of closing volume to vital capacity, ratio of closing capacity to total lung capacity, and change in N2 concentration than fast inspiratory flow. Voluntary regulation of the expiratory flow resulted in smaller ratios of closing volume to vital capacity and closing capacity to total lung capacity than when flow was regulated by a resistance. Prolonged breath holding of the inspired O2 led to larger ratio of closing volume to vital capacity and ratio of closing capacity to total lung capacity. To obtain uniform, comparable closing volumes, it is suggested that the subject inspire slowly, control expiratory flow (preferably voluntarily), and not pause between inspiration and expiration.

Adult↗
PubMed1975

Medical surveillance for occupational respiratory diseases.

Three simple procedures should be used to monitor industrial populations for the development of respiratory disease: (1) History, (2) chest x-ray, and (3) spirometry. The history should be complete and include occupational as well as medical information. Only a P-A x-ray examination of the chest is necessary. Accurate performance of spirometry with reliable equipment can provide useful evidence of physiologic impairment. Serial test results from each employee should be carefully compared to best assess the early development of occupational respiratory disease.

Forced Expiratory Volume↗