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Biomedical subjects

B Majmudar

Publications and source records attributed to B Majmudar.

At least 37 records · Page 2Linked to original sources
PubMed1988

Granuloma inguinale (donovanosis) in women.

A ten-year review (1973-1983) revealed 13 cases of documented granuloma inguinale at Grady Memorial Hospital, Atlanta. The patients' ages ranged from 17 to 77, with the majority in their early 20s. The initial presentation of granuloma inguinale included large, fungating labial ulcers, labial swelling, vaginal discharge, rectovaginal fistulae and hematuria. Common presumptive diagnoses included carcinoma, herpes, syphilis and granuloma inguinale. The final diagnosis was made with cytology and/or tissue examination with the help of special stains to demonstrate the causative organism, Calymmatobacterium granulomatis. Granuloma inguinale is rare and difficult to diagnose, but with physician awareness, cytology and biopsy, it should not be missed.

Adolescent↗
PubMed1987

Modification of caecal lymphoid tissue and relationship to granuloma formation in sporadic ileocaecal tuberculosis.

The histopathology of eight cases of sporadic ileocaecal tuberculosis is described with particular reference to caecal lymphoid tissue. Adjacent to areas of ulceration in all cases there was an increase in lymphoglandular complexes (LGC) and proliferation of paravascular lymphoid aggregates deeper in the gut wall. Early and fully-developed granulomas were present in locations comparable to LGC and lymphoid aggregates. Immunocytochemical staining of paraffin sections with monoclonal antibodies UCHL1 (T-lymphocyte membrane antigen) and LN-1, LN-2 and LN-3 (B-lymphocyte and Ia antigens) showed that central cells in LGC and lymphoid aggregates stained like follicular centre B-lymphocytes. Both LGC and lymphoid aggregates had a distinct peripheral rim of cells staining as T-lymphocytes, but LN-2 and LN-3 also stained scattered peripheral cells, some of which were recognizable as interdigitating reticulum cells. Most lymphocytes within and around granulomas stained as T-lymphocytes. In lymph nodes, granulomas appeared to occur first at the periphery of, and later to efface, cortical follicles. Lymph node compartments showed the expected T- and B-zonation, and lymphocytes associated with granulomas stained as in caecal granulomas. Our observations suggest that LGC are sites of mycobacterial antigen sampling, of T-lymphocyte and macrophage activation, and of (potential) granuloma formation in ileocaecal tuberculosis. Lymphoid aggregates deeper in the gut wall probably subserve a similar function during extension of the lesion. The location of both LGC and lymphoid aggregates beside lymphatics is suited to the transfer of their cellular constituents throughout the gut and to regional lymph nodes.

Aged↗
PubMed1987

Fibroadenomas with stromal cellularity. A clinicopathologic study of 21 patients.

Data on clinical and pathologic features of tumors from 21 patients who had breast tumors compatible with juvenile (cellular) fibroadenomas (JCF) were reviewed. All patients were black females ranging in age at time of presentation from 10 to 39 years, with a median age of 15 years. Follow-up (median period, six years) was obtained for 20 patients. Patients were categorized into two groups; 13 had solitary lesions and eight had multiple and successive lesions. No histologic differences were observed between JCF occurring as solitary or multiple tumors or between lesions occurring in patients younger and older than age 20 years. The JCF was shown to be a fairly distinct clinicopathologic entity that characteristically occurred in adolescents, but which was occasionally seen in young adults. It had a benign course, characterized by synchronous and metachronous multicentricity, rather than local recurrence.

Adenofibroma↗
PubMed1986

The relationship between juvenile laryngeal papillomatosis and maternal condylomata acuminata.

This study attempted to delineate the relationship between juvenile laryngeal papillomatosis (JLP) in children and a history of maternal condyloma at the time of their birth. Over a period of 53 years, from 1930 to 1983, 44 children with the clinical diagnosis of JLP were identified. A maternal history of genital condyloma at the time of their birth was sought. Sixteen had incomplete records. Of the remaining 28, 15 children (54%) had a maternal history of vulvar condyloma at the time of delivery or pregnancy. The association between maternal condyloma and JLP needs to be recognized since the latter causes considerable morbidity and occasional mortality. Additional studies are indicated to establish if cesarean section is necessary in pregnant patients with genital condyloma to prevent JLP in their offspring.

Adult↗
PubMed1985

Teratoma of the umbilical cord.

A case of teratoma of the umbilical cord is described. Four previous reports of this entity are briefly reviewed, and a detailed description of the current case is presented. The histogenesis of teratomas at this unusual site is discussed. The features that distinguish teratomas of the umbilical cord and placenta from acardius fetus are enumerated.

Adult↗
PubMed1984

Ultrastructure and immunohistochemical localization of estradiol in three thecomas.

Three ovarian thecomas were studied by ultrastructural and immunohistochemical techniques. In each tumor, a small number of tumor cells stained for estradiol. Vacuolated as well as plump non-vacuolated tumor cells were positive, but spindle-shaped cells were negative. Ultrastructural examination showed two principle cell types. Type I cells were immature mesenchymal cells that differed from typical steroid-secreting cells because only a minority had conspicuous smooth endoplasmic reticulum, although mitochondria often had tubular cristae. Type II cells were distinguished by abundant intermediate (10-nm) microfilaments and round mitochondria with incomplete cristae and empty centers. Focal smooth muscle differentiation was present in each tumor. Adherens-type intercellular junctions, including desmosomes in one case, and degenerate cells with markedly vesiculated cytoplasmic membrane systems were also present. Lipid was not abundant, but it was more conspicuous in degenerate cells and in type II cells. Thecoma cells thus closely resemble both ovarian stromal cells and theca interna cells, which are known to be capable of steroidogenesis. The localization of estradiol in a minority of tumor cells in each thecoma suggests that thecoma cells, too, are capable of steroid synthesis and supports the popular concept that hyperestrogenism in patients with thecomas may be the result of estradiol secretion by these tumors.

Adolescent↗
PubMed1984

Intern's choice.

Explore the source record for details and available documents.

Career Choice↗
PubMed1983

Ovarian granulosa cell tumors--immunohistochemical localization of estradiol and ultrastructure, with functional correlations.

The authors studied immunohistochemical localization of estradiol and ultrastructure in 11 ovarian granulosa cell tumors in an effort to establish the cellular source of increased estrogen in patients with granulosa cell tumors. Estradiol was identified by the immunoperoxidase method in 10 tumors, and staining was confined to scattered groups of granulosa cells or isolated granulosa cells. The majority of tumor cells in all 5 cases examined by electron microscopy were undifferentiated cells, but in 2 cases, a small percentage of tumor cells contained mitochondria with tubular cristae and well-developed smooth endoplasmic reticulum. Interpreted in conjunction with in vitro studies of granulosa cells, the results suggest that neoplastic granulosa cells may resemble ovarian follicular granulosa cells of all stages of maturation and are capable of estrogen production.

Adult↗
PubMed1983

Diagnostic endometrial aspiration with the Karman cannula.

Endometrial aspiration with the Karman cannula can be used to detect endometrial pathology. To document the feasibility and accuracy of endometrial aspiration with this cannula, 49 women were evaluated by this technique prior to diagnostic dilation and curettage (D&C). Completion rates for both endometrial aspiration and D&C were 96%. Endometrial aspiration yielded tissue adequate for histologic evaluation in 82% of cases as compared with 76% of D&C cases. Three cases of cancer (two endometrial and one endocervical) were identified by both techniques. A majority of patients expressed a preference for endometrial aspiration over D&C. Endometrial aspiration with the Karman cannula appears to be a convenient, accurate and acceptable method of detecting endometrial pathology.

Biopsy, Needle↗
PubMed1983

Salpingitis isthmica nodosa: a high-risk factor for tubal pregnancy.

A prospective and retrospective study was undertaken to analyze pathologic lesions in fallopian tubes of 200 consecutive tubal pregnancies. In a retrospective analysis of 100 cases of tubal pregnancy, seven cases were reported to contain salpingitis isthmica nodosa. After review, 27 cases were found to have this lesion. The prospective study employed 100 consecutive tubal pregnancy specimens thoroughly sectioned for microscopic examination. Salpingitis isthmica nodosa was observed in 57 of these 100 cases. In a control series of 100 fallopian tubes obtained from autopsy and surgical specimens, five tubes showed salpingitis isthmica nodosa. These observations indicate a significant association between tubal pregnancy and salpingitis isthmica nodosa.

Adolescent↗
PubMed1982

Nodular fasciitis (pseudosarcomatous fasciitis) of the vulva.

Nodular fasciitis (pseudosarcomatous fasciitis) is a benign nonneoplastic connective tissue proliferation of unknown pathogenesis, which most commonly involves the upper limb subcutaneous fascia. Nodular fasciitis of the vulva is an entity rarely encountered by gynecologists or pathologists, but has considerable potential for misdiagnosis as sarcoma and for inappropriate treatment. The patient, a 32-year-old black female, presented with a 3-cm right labial mass, which was nodular, rubbery, and yellowish-white on section. Microscopically, there was an admixture of large mesenchymal cells, small blood vessels, and lymphocytes in a sparsely collagenous matrix. Other features included extravasated erythrocytes, intercellular clefts, and pseudocysts. Although mitoses were common (8 per 10 high power fields), there were no atypical mitoses and no bizarre tumor giant cells. The large mesenchymal cells were identified by electron microscopy as myofibroblasts, cells which abound in a variety of other reactive and non-neoplastic conditions. It is important not to misdiagnose nodular fasciitis as a vulvar sarcoma, because nodular fasciitis requires only simple excision and does not recur or metastasize.

Adult↗
PubMed1981

Respiratory obstruction caused by a multicentric granular cell tumor of the laryngotracheobronchial tree.

An unusual case of acute respiratory obstruction caused by multicentric granular cell tumors of the laryngotracheobronchial tree is presented. The patient also had granular cell tumors in the tongue, vulva, and chest wall. Multiplicity of the lesions in the left lung and recurrent episodes of intercurrent pulmonary infections necessitated left pneumonectomy. The extreme rarity of such a clinical circumstance is illustrated by a review of the literature. Salient clinical and pathological features of the tumor are briefly discussed.

Adult↗
PubMed1981

Myocardial abscesses unassociated with infective endocarditis.

Review of 3,084 autopsies from 1967 to 1977 at Grady Memorial Hospital Yielded 14 cases of myocardial abscess unassociated with infective endocarditis acceptable for our study. No case was diagnosed ante mortem. Gram-negative organisms, fungi, and Staphylococcus aureus were isolated. Underlying conditions included alcoholic hepatitis, acute myocardial infarction, systemic lupus erythematosus, and various malignancies. The physical examination, chest roentgenogram, and electrocardiogram were not helpful in establishing a diagnosis. complications included pericarditis and congestive heart failure. A high index of suspicion in a debilitated patient not responding to conventional antimicrobial therapy appears to be the only clue to the antemortem diagnosis. Cardiac scintigraphy is promising as a possible means of earlier detection.

Abscess↗