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Biomedical subjects

B Mair

Publications and source records attributed to B Mair.

5 recordsLinked to original sources
PubMed1998

Evaluation of changes in hemoglobin levels associated with ABO-incompatible plasma in apheresis platelets.

BACKGROUND: Hemolytic transfusion reaction is considered a rare complication of platelet transfusion. If minor ABO incompatibility exists (donor antibody directed against recipient's red cells [plasma-incompatible platelets]), however, the antibodies present in the plasma of platelets may cause acute hemolysis. A retrospective study was performed to identify possible hemolysis related to the transfusion of plasma-incompatible apheresis platelets. STUDY DESIGN AND METHODS: Acute hemolysis due to low-titer anti-A present in group O apheresis platelets transfused to a group A patient is reported. Pretransfusion and posttransfusion hemoglobin levels were evaluated in 16 non-group O autologous bone marrow transplant patients receiving apheresis platelets. All patients received, within 24 hours, both ABO-identical and plasma-incompatible platelet transfusions. No red cells were transfused during the time between the collection of the pretransfusion and posttransfusion hemoglobin samples. RESULTS: A total of 24 evaluable paired platelet transfusions in the 16 patients were compared. The mean change in hemoglobin following transfusion of the ABO-identical and plasma-incompatible platelets was -0.50 g per dL and -0.11 g per dL, respectively (p = 0.193). CONCLUSION: There was no significant change in the hemoglobin concentration associated with the transfusion of plasma-incompatible apheresis platelets (minor ABO incompatibility) in our study group. The case reported here represents the only hemolytic transfusion reaction identified among 46,176 platelet transfusions performed at this hospital, despite approximately 21 percent of all platelet transfusions being plasma incompatible. The risk of such a reaction remains low.

ABO Blood-Group System↗
PubMed1998

Hypotensive reactions associated with platelet transfusions and angiotensin-converting enzyme inhibitors.

BACKGROUND AND OBJECTIVES: To determine the cause of hypotensive reactions associated with platelet transfusions in coronary artery bypass surgery patients. MATERIALS AND METHODS: Platelet transfusion reactions that occurred during a 3-month period were retrospectively reviewed. RESULTS: Eighteen transfusion reactions occurred in 16 patients. Sixteen of the reactions were hypotensive and occurred in 14 patients transfused with platelets through negatively charged bedside leukocyte reduction filters. All 14 patients had received angiotensin-converting enzyme (ACE) inhibitors prior to transfusion. CONCLUSION: Preliminary findings suggest a new type of transfusion reaction associated with the use of negatively charged leukocyte reduction filters during platelet transfusions to patients on ACE inhibitors.

Aged↗
PubMed1996

Monitoring for undertransfusion.

BACKGROUND: Most published reviews and audits of blood and blood component transfusion have focused on the issue of overtransfusion and on the inappropriate use of red cell components. There is growing concern that efforts to curb unnecessary transfusions may result in a trend toward undertransfusion of patients. There is little published information that addresses this issue or the magnitude of this practice. STUDY DESIGN AND METHODS: Undertransfusion was evaluated by examining the transfusion records from a 3-month period for 55 patients who met the study criteria of having either a hemoglobin level < 7 g per dL or a platelet count of < 10 x 10(9) per L. If the identified patient did not receive a transfusion within 24 hours of the reported hemoglobin level or platelet count, the medical record was reviewed by a resident physician. RESULTS: A total of 213 individual hemoglobin levels and platelet counts, representing the 55 patients, met our transfusion criteria. All except 8 of the identified patients received red cells and/or platelet transfusions. Reasons for not transfusing red cells included the patient's response to nutritional support and iron supplementation, refusal of blood, and noncompliance. Reasons for not transfusing platelets included falsely low platelet count because of platelet clumping in vitro, contraindication based on clinical diagnosis (e.g., immune thrombocytopenic purpura), and the patient's death before transfusion. CONCLUSION: Red cell and platelet transfusions were appropriately ordered for all patients who met the transfusion criteria. Undertransfusion is not a problem at this institution according to the criteria established. It is recommended that other institutions expand their blood utilization audits to include investigation for evidence of undertransfusion. Further research regarding the issue of undertransfusion is warranted and could be expanded to include other components.

Alcoholism↗
PubMed1987

Abnormally high values for direct bilirubin in the serum of newborns as measured with the DuPont aca.

To assess notably high measurements of direct bilirubin in the serum of newborns obtained on the DuPont aca analyzer, the authors compared results from the aca instrument with the results from the Technicon RA-1000 analyzer. Total and direct bilirubin values in 11 serum samples of newborn babies were measured in parallel on both instruments. There was good correspondence between the two instruments in determination of total bilirubins. However, the diazotized sulfanilic acid method (used by both instruments) yielded much higher direct bilirubin values on the aca analyzer than on the RA-1000. The possibly spuriously elevated direct bilirubin results produced by the aca may cause clinical confusion.

Bilirubin↗