Search PubMed⌕ Search

Biomedical subjects

B Magnusson

Publications and source records attributed to B Magnusson.

At least 91 records · Page 5Linked to original sources
PubMed1978

Triclocarban: evaluation of contact dermatitis potential in man.

Triclocarban was subjected to a profiling of its dermatitis producing potential including irritancy (21-day cumulative irritancy potential and application to 213 normal controls), phototoxicity (method of Marzulli), predictive contact sensitization (modified Draize method), predictive phototesting and battery screening in 2200 dermatitis patients, in an effort to define its relative dermatitis potential. The allergic contact dermatitis potential of triclocarban following bar soap use appears minimal.

Carbanilides↗
PubMed1977

The adjuvant effect of tuberculin in experimental sensitization to merthiolate.

When guinea pigs were sensitized to tuberculin by exposure to complete Freund's adjuvant the size of the intradermal PPD test was positively correlated to the body weight of the animal. Old Tuberculin showed stimulating effect in a subsequent sensitization to merthiolate (thimerosal). The high frequency of delayed cutaneous allergy to merthiolate in Swedish population is probably explained by sensitization through intradermal testing with tuberculin containing merthiolate as a preservative.

Animals↗
PubMed1977

Gastrointestinal blood loss in man during administration of two ampicillin esters.

The gastrointestinal blood loss during intake of two ampicillin esters (pivampicillin and bacampicillin) was studied in 10 male volunteers. A radioactive chromium method was used. The study was performed with a double-blind cross-over technique. Pivampicillin seemed to give a slightly higher increase in gastrointestinal blood loss compared to placebo and bacampicillin but these bleedings are probably of no clinical significance.

Adult↗
PubMed1977

A comparative study of gastrointestinal bleeding during administration of ketoprofen and naproxen.

The gastrointestinal blood losses arising after ketoprofen and naproxen therapy were studied in 12 male volunteers. A 51Cr-technique was used and the study was carried out using a double-blind crossover design. The median daily blood losses were 3.3 and 1.2 ml after ketoprofen and naproxen, respectively. Both preparations caused significantly increased gastrointestinal blood losses compared with preceding control periods, but there was no statistically significant difference between the two preparations.

Administration, Oral↗
PubMed1977

Iron absorption in patients with dermatitis herpertiformis.

Iron absorption has been studied in patients with dermatitis herpetiformis (DH). Four patients out of 20 had iron deficiency, defined as absence of or only traces of haemosiderin in bone marrow smears. These four had adequate absorption of ferrous iron. The iron deficiency in at least 3 of them was ascribed to increased iron loss. The results indicate that, although having a mild to moderate malabsorption syndrome, DH patients can be expected to exhibit adequate absorption of orally administered iron. Explanations of a negative iron balance other than defective absorption should therefore be sought.

Adolescent↗
PubMed1976

Measurement of iron absorption from compositite meals.

In earlier studies using the recently introduced extrinsic tag technique meals were carefully minced and mixed with the extrinsic tracer to ensure complete isotopic exchange. In the present paper the validity of simpler and more realistic techniques to label and serve composite meals was evaluated. Equal or almost equal absorption figures were found when mixing the label homogenously into a meal, adding it dropwise, or mixing it into the most bulky component of the meal. The necessity of serving the meals in a realistic way was underlined by the finding of higher absorption from a meal in which the components were served separately than from meals mixed before serving. The results of the present study indicate that the validity of using the reference dose as a basis for comparison of absorption data in different groups, was higher when serving the reference dose and the meals on consecutive days than when serving 2 weeks apart. This was true especially in women. The present findings imply that it is both necessary and possible to design simple labeling techniques that allow valid measurements of iron absorption from composite meals. Moreover, when determining the schedule of serving the meals and the reference doses the findings in the present paper must be carefully considered.

Adult↗
PubMed1976

Sensitization to propantheline bromide, trichlorocarbanilide and propylene glycol in an antiperspirant.

Out of 14 patients with axillary dermatitis due to an antiperspirant, and with positive patch test reactions to the product, the sensitizer could be demonstrated in 12. Of these, 11 were positive to propantheline bromide, 3 to trichlorocarbanilide and one to propylene glycol. The antiperspirant contains 90% propylene glycol, which is an irritant under occlusion. When applied in the axillae, where occlusive conditions usually prevail, an irritant effect of propylene glycol may have promoted sensitization to the ingredients of the antiperspirant.

Adult↗