Returning biology to carcinogenicity testing.
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Biomedical subjects
Publications and source records attributed to B M Wagner.
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Examined the relations of parent and child behaviors with children's perceptions of their academic competence. 74 high-achieving third-grade children, with varying levels of perceived academic competence, were observed working with mothers and fathers both on solvable tasks (Period 1) and during a period that included some unsolvable tasks (Period 2). Results indicated that children's perceived academic competence was positively related to father warmth, both at Period 1 and at Period 2. Children's perceived academic competence was also positively related to their own behavior when working with fathers at Period 2. Specifically, children with higher perceived academic competence showed more emotional restraint and were more self-reliant when working on tasks at Period 2 than were children with lower perceived academic competence. The results indicate that there are systematic, observable correlates of children's self-reports of their perceived academic competence.
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Examined the roles of gender, instrumentality, and expressivity as moderator of the relations between stressful events and psychological symptoms in samples of junior high (n = 93), senior high (n = 140), and college students (n = 145). Female adolescents in all three samples reported more overall negative events than did males. Females in the junior and senior high samples reported more negative interpersonal stresses than did males. However, there were no indications in any of the samples of a stronger relation between negative events and psychological symptoms for adolescent females than males. Further, there was little evidence that instrumentality or expressivity moderated the relations between negative events and psychological symptoms. In each sample, certain stresses were most strongly related to psychological symptoms: family stresses in the junior high, peer stresses in the senior high, and academic stresses in the college sample. Implications of the findings for developmental changes in stress during adolescence are discussed.
As a student of cardiovascular pathology in humans and animals for 35 yr, I am impressed with the new knowledge of the molecular biology, biochemistry, physiology and pharmacology of the heart in health and disease. All of this information creates a dynamic setting for the interpretation of structural findings. Before the advent of open-heart surgery and the cardiac biopsy, pathologists had to rely largely on accumulated autopsy data. Today, a great deal of empiric dogma has given way to good science. In 1962, I met Professor FZ Meerson in his laboratory in the Institute of Normal and Abnormal Physiology, Moscow. He had just characterized the biochemical events leading to myocardial degeneration and cell death in animals with acute aortic constriction (19). His pioneering work provided the basis for understanding the sequential changes in myocytes in the failing heart. These cellular events corresponded to the astute clinical observations made by Osler in 1886. Meerson was enthusiastic about the potential of electron microscopy. However, he was convinced that when we had the techniques to identify and localize in the cardiac muscle cell the key chemical entities associated with changing function, we would rapidly understand pathogenesis leading to new therapies. Today, almost 30 yr later, Meerson's prophetic insights have become a reality. I had assured Meerson that when the tools were available to study the dynamic pathology of the heart, pathologists would lead the way. Dynamic pathology of the heart is a concept since the words are somewhat contradictory. The term serves as a symbol for a state of mind which refuses to interpret cardiovascular pathology in static, histologic words.(ABSTRACT TRUNCATED AT 250 WORDS)
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The hypothesis that negative daily events mediate the relationship between major negative events and psychological symptomatology was tested using a three-wave, three-variable panel design. Measures of major and daily life events and psychological symptomatology were administered to 58 older adolescents at three time points during the transition from high school to college. The results indicated that the pathways from major life events to daily events and from daily events to psychological symptomatology were significant at each of the time points, but that the direct pathways from major events to psychological symptomatology were not significant at any time point. Thus, the hypothesis was fully supported. The findings are discussed in light of their implications for an integrative theory of the process by which major and daily events have an effect on psychological symptomatology.
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