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Biomedical subjects

B M Sagalovich

Publications and source records attributed to B M Sagalovich.

At least 19 recordsLinked to original sources
PubMed2001

[Surgical treatment of Meniere's disease and its pathophysiological validation].

The authors analyse their own and literature data on surgical treatment of Meniere's disease (MD) as intervention on the endolymphatic sac with assessment of various modifications by long-term results, on sympathetic intraaural and extraaural lesions. Surgical interventions on the endolymphatic sac are pathophysiologically validated. Insufficient knowledge on hydrodynamics in the internal ear labyrinth and the role of endolymphatic hydrops in MD pathogenesis hampers assessment and further development of surgical treatment of the disease. Future lines of the research in Meniere's disease and its treatment are outlined.

Humans↗
PubMed1998

[Topic problems of gerontology in otorhinolaryngology].

The paper characterizes age-specific involution of the ENT tissues, acoustic and vestibular analyzers, hearing and equilibrium defects. Original investigations of the authors give wider possibilities of early detection of age-related failure of the internal ear functions. Relevant tests are proposed.

Adolescent↗
PubMed1983

[Effect of changes in electrolyte composition of the perilymph on endocochlear potentials].

Perfusion of the cochlear perilymphatic space was performed in guinea pigs with complete or partial removal of K+, Na+ or Ca++ from the solution. The most obvious changes of the endocochlear potential occurred in the deficiency of Na+ in the perilymph: i. e., after a short increase the potential steadily diminished in accordance with the degree of Na+ deficit in the perilymph. The deficit of K+ in the perilymph caused a lesser and reversible reduction of the potential. The absence of Ca++ in the perilymph did not affect the potential.

Animals↗
PubMed1981

[Study of the mechanism of auditory adaptation by simultaneous recording of cortical auditory evoked potentials and cochlear microphonic potentials].

Auditory adaptation, apart from the effect of the neurotropic drugs, galanthamine, GABA and nanophyn on this adaptation, was examined in 35 rabbits exposed to white noise (90 dB, re 2.10(-5) Pa, 10 min) by concurrent recording of evoked potentials of the brain and microphonic potentials of the cochlea. The results suggest that the mechanism of auditory adaptation is determined by the processes that occur in the synapses of the auditory system central parts and is monitored by the sympathetic nervous system.

Adaptation, Physiological↗
PubMed1980

[Dynamics of the harmonic components of the cochlear microphonic potential during acoustic overloading and exposure to ototoxic substances].

The 2nd and the 3rd harmonic components of microphonic potentials in the rabbit cochlear, under the influence of sound stimuli of different intensity, developed simultaneous and equal changes of their characteristics of the odd harmonic as well as of the basic tone. The even harmonic did not depend on the dynamic characteristics of the basic tone of microphonic potentials. The even harmonic developed its own specific changes. In separate experiments, the effects of sound overload, etacrine acid and streptomycin on the dynamic characteristics of the even harmonic, were studied.

Animals↗
PubMed1978

[The meaning of nonlinear distortions in the internal ear for acoustic and ultrasonic stimuli].

A comparative study of nonlinear distortion of microphonic potentials in the rabbit cochlear at the air and bone conduction showed equal values for the air as well as for the within the ultrasonic frequency range did not exceed the hearing spectrum values. The hearing response to ultrasonic stimuli was found not to be due to formation of overtones of ower frequencies but to represent rather the direct cochlear response.

Acoustic Stimulation↗
PubMed1977

[Relationship between the endocochlear potential and metabolism in the vascular stria of the inner ear].

Effects of dihydrostreptomycin, etacrine acid and ATPh on the endocochlear potential in guinea-pigs depended on the dosage and means of administration. Dihydrostreptomycin suppressed the potential only when perfusing the perilymphatic space or being microinjected into the endolymphatic duct. I. v. administration of etacrine acid suppressed the potential with its following partial restoration. I.v. administration of ATPh in large doses suppressed the potential for a short period but did not prevent the ototoxic effect of etacrine acid. ATPh in small doses did not suppress the potential but exerted the protective effect.

Adenosine Triphosphate↗
PubMed1976

[Electrophysiologic characteristics of rapid auditory adaptation].

In 32 rabbits, dependence of character of fast auditory adaptation on frequency of the sound stimulation was shown. Specific features of the adaption in conditions of switching off of the inner ear receptors with streptomycine were revealed. The fast adaptation was concluded to have a peripheral mechanism. Methods of the adaptation studying with the acid of action potentials of the 8th nerve and microphone potentials of the cochlear were compared under conditions of sound overload, and differences in results of measuring the fast adaptation were explained from the standpoint of dependence upon intensity of sound simulation.

Action Potentials↗
PubMed1976

[Dependence of the evoked potentials of the auditory cortex on the parameters of acoustic stimulus].

Experiments were conducted on 40 rabbits; a study was made of the dependence of the amplitude and the latent period of the auditory evoked potentials on the intensity, duration, accretion front, frequency and the rhythm of the acoustic stimuli (the intervals between them). The intensity of the stimuli, the accretion front and the interstimulus intervals proved to influence the induced potential parameters.

Acoustic Stimulation↗