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Biomedical subjects

B M Potter

Publications and source records attributed to B M Potter.

28 records · Page 2Linked to original sources

Echocardiographically assisted balloon atrial septostomy.

Balloon atrial septostomy is an accepted method for palliation of certain types of congenital heart disease. However, malposition of the balloon may lead to cardiac perforation, avulsion of an atrioventricular valve, or laceration of the systemic or pulmonary veins. Inasmuch as single-phase fluoroscopy may not identify balloon position correctly and as biplane fluoroscopy adds significant radiation exposure, two-dimensional echocardiography has been used to assist in balloon atrial septostomy in ten infants. The catheter is advanced from the inferior vena cava to the right atrium across the foramen ovale to the left atrium with the echo transducer in the subxiphoid position. The balloon is inflated and its position within the left atrium is confirmed by echo. The catheter is withdrawn according to the technique of Rashkind. Withdrawal is halted when the balloon traverses the atrial septum. Adequate septostomy is indicated on echo by a defect at least 5 mm in diameter and by flapping of the inferior rim of the atrial septum. There were no complications using this technique and a clinically adequate septostomy was achieved in each patient. Two-dimensional echocardiography-assisted balloon atrial septostomy minimizes risk of complications and decreases exposure to ionizing radiation.

Cardiac Catheterization↗

Portal decompression in infants and children with the interposition mesocaval shunt.

The mesocaval graft for portal decompression is applicable in infants and children with portal hypertension secondary to extrahepatic or intrahepatic causes. It is recommended in patients in whom extensive previous surgery in the portahepatis (Kasai procedure) would make dissection of the portal vein difficult and endanger the integrity of the functioning biliary conduit. It can be performed in patients who have had previous splenectomy or in whom portacaval or splenorenal shunts have failed. Autogenous jugular vein is favored for creation of the shunt.

Adult↗

Left ventricular pseudotumor: a two-dimensional echocardiographic sign of aortic insufficiency.

A left ventricular, mass-like echocardiographic density (a pseudotumor), present only during diastole and not attached to any intracardiac structure, was present in 77 of 1,820 consecutive 2-dimensional echocardiograms performed with a rotating-head transducer. Evaluation of the patients with a pseudotumor demonstrated that aortic insufficiency of mild to moderate degree was the most commonly associated lesion. Of the 61 patients with aortic insufficiency in our series, 69% had a left ventricular pseudotumor. Of the cases with a pseudotumor and aortic insufficiency, none had severe aortic insufficiency. Of the 1,759 patients without aortic insufficiency, a left ventricular pseudotumor was present in 2%. In our series, the sensitivity of left ventricular pseudotumor for aortic insufficiency was 69% and the specificity was 98%.

Aortic Valve Insufficiency↗

Prenatal alcohol exposure: effects on acoustic startle and prepulse inhibition.

The present study evaluated the effects of prenatal exposure to alcohol on the acoustic startle reflex and prepulse inhibition in rats. Pregnant rats consumed an average of 12.36 g/kg/day of ethanol in a saccharin solution which served as their sole fluid source throughout gestation. Their offspring were found to be developmentally delayed on tests of physical maturation, but were not consistently impaired on tests of neuroreflexive development when compared to pair-fed and ad lib control groups. With development, subjects in the ethanol exposed group exhibited enhanced reactivity to an acoustic startle stimulus, which was evident at 35 but not at 21 days of age. In contrast, general activity levels were similar for all groups at 35 days of age, and there was no apparent disruption of the inhibitory effects of a prepulse stimulus. These results provide evidence that in utero exposure to alcohol may result in age dependent hyperreactivity, with no obvious disruption of normal prepulse inhibition or general activity levels.

Acoustic Stimulation↗