[Choosing among students who passed all tests...].
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Biomedical subjects
Publications and source records attributed to B M Persson.
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We examined factors which may lower the mean amputation age and factors which may serve as predictors of success or failure of amputations in the lower extremities for vascular disease in 177 consecutive amputees. Smoking lowered the mean amputation age by 9 years and diabetes by 3 years. Preoperative absence of gangrene in the ischemic limb predicted a higher risk of failure compared to patients with gangrene. Also preoperative hemoglobin > 120 g/L gave a higher risk of failure. Failure to heal was not correlated with age, sex, diabetes, level of amputation, previous vascular surgery, smoking, preoperative blood pressure, serum creatinine, erythrocyte sedimentation rate, blood glucose or temperature.
20 pairs of lateral malleolar fracture were created by an osteotome at autopsy of elderly patients and repaired on one side with staples and cerclage wire and on the other side with plate and screws. The stability of the fixation was then tested in an apparatus creating outward rotational load. The breaking load in fractures fixated with staples and wire was about 60 percent (18 SD 7.6 Nm) of the plated fibular fractures (32 SD 11 Nm). However, at an outward deflection up to 30 degrees there was no difference in breaking load with the two methods of fixation.
All major amputations of the lower limb due to occlusive arterial disease were studied prospectively and consecutively during one year in the 5 hospitals in Malmöhus county, Sweden. The patients were followed for 6 months after the primary amputation of which 136 were through the tibia, 6 through the knee and 35 through the femur. One hundred and seventy-seven patients (92 men and 85 women) were included; 49% were 80 years or older and 40% were diabetic. At 6 months, 85 of the surviving 109 patients had healed stumps, 10 were not healed and 14 had been revised or reamputated. Half the survivors used a prosthesis daily. There was no significant difference in healing related to sex, age, diabetes or the level of amputation, but diabetics were more often bilateral amputees. The mortality at 6 months was 38% and at 4 years 72%.
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During the 11-year-period from 1970 to 1980, 799 total hip arthroplasties with metal-on-plastic prostheses were performed for primary osteoarthritis. In all cases high viscosity cement was used, but not under pressure; acetabular cartilage was removed, but the femoral canal was not plugged. The rate of revision and risk factors were evaluated by survivorship analysis. The overall cumulative revision rates were 11%, 14% and 19% after 8, 10, and 14 years respectively. When prophylactic antibiotics were not used, there was a significant risk of revision for infection. The risk of revision for mechanical loosening of both the acetabular and femoral components was significantly increased for men, younger patients, and if a snap-fit prosthesis with a 35 mm head and short wedged stem was used. The survivorship findings were validated by multivariate statistical analysis.
Symphysial osteomyelitis has been distinguished from osteitis pubis because of the more serious nature of the disease. We report a case in which there was a pelvic separation similar to that seen after trauma or pregnancy. The previously undescribed complications of bladder perforation and pelvic instability are also noted. There was no predisposing cause in this case, in contrast to the 40 previously reported. The causative organism was staphylococcus aureus, but pseudomonas aeruginosa and escherichia coli have also been found in other cases.
After hip replacement for primary arthrosis, 69/104 patients younger than 60 years returned to work within 2 years. Long preoperative sick leave increased the risk of both retirement and long postoperative sick leave. The retirement rate was also influenced by occupation, whereas sex, age, or bilateral operations had no influence on postoperative retirement nor on postoperative sick leave.
In a consecutive series of 280 patients with virgin soft-tissue lesions who were referred to the Orthopedic Oncology Center in Lund because of suspected malignancy, 53 had lesions that proved to be sarcoma, 10 metastatic carcinoma, and 217 benign tumors or tumorlike conditions. Lipoma was the most common benign tumor. Deep site, size exceeding 5 cm, patients aged over 50 years, and tumor located proximally in the extremities increased the probability of sarcoma to 50 per cent.
From 1974 through 1981, total arthroplasty was performed for arthrosis following congenital dislocation in 25 hips in 17 patients. Pain was the main indication for surgery. Early complications were two dislocations and one deep venous thrombosis. One malpositioned socket and one loosening of the femoral prosthesis and socket were revised. At follow-up 2-9 years postoperatively, 16 hips were excellent, eight good, and one poor. The dysplastic pelvis and femur require implants of special design, and the original acetabulum should be prepared and reinforced at surgery. A radiographic method for calculation of the center position of the hip before and after surgery proved simple and exact.
The internal pressure was measured in 25 soft-tissue tumors in 24 patients. High pressure was associated with pain at rest and tumor necrosis.
Sixteen patients with an intramuscular or intermuscular high-grade Stage-IIA soft-tissue sarcoma in the upper or lower extremity were treated by en bloc myectomy of one or several muscles without preoperative or intraoperative open biopsy. The total anatomical compartment containing the tumor, bounded by deep fascia and major intermuscular septa, as defined by the Musculoskeletal Tumor Society, was not removed. Adjunctive therapy was not given. The clinical and radiographic diagnosis of sarcoma was supported by the study of cells obtained by fine-needle aspiration in eleven patients. During a median length of follow-up of seven years (range, one to fourteen years), there was only one local recurrence. Thus, it is our experience that, in addition to deep fascia and major intermuscular septa, an uninvolved muscle fascia that has not been transgressed by an open biopsy is an adequate barrier against tumor growth or so-called skip metastases, and that with the proper indications total compartmental resection is not necessary even for a high-grade sarcoma.
Since 1972, we have included fine-needle aspiration cytology in the pre-operative evaluation of soft tissue lesions referred to our Orthopedic Oncology Group. In 365 consecutive patients the cytodiagnosis was correctly malignant in 66/74 tumors and correctly benign in 260/271 lesions; cytology was non-diagnostic in four sarcomas and 16 benign lesions. The final pre-operative diagnosis should be based on all pre-operative data to minimize the effect of any misjudgement as regards cytodiagnosis; only two of the 19 false cytodiagnoses were of consequence for the patient. We conclude that aspiration cytology used in this way is a valuable adjunct to determine the further management of soft tissue tumors.
Extensive local excisions of skeletal tumors in the knee region create reconstruction problems with several alternative solutions. Custom-made endoprostheses now compete with joint homografts and fusion with autogenous bone-grafts. Artificial fusion utilizing an extra long Küntscher-nail and acrylic cement as a spacer is a fourth possibility with the advantages of immediate ambulation and weight-bearing, here presented in two cases. The expected disadvantages of loosening in long time survivors can be taken care of using one of the above-mentioned alternatives. This revision can be made after completion of adjunctive chemotherapy or later when called for by the occurrence of pain or instability.
The frequency of and the factors causing dislocations of 71 total hip replacements and 59 hemiarthroplasties following failure of nailed femoral neck fractures were investigated. Dislocations were frequent and occurred in four (6%) and seven (l2%) hips respectively. Malposition of the components increased the risk for dislocation. A well-positioned total hip replacement was more stable than a hemiarthroplasty.
Two cases of ileopectineal bursitis following total hip replacement are presented. Inflammation, infection and trauma are discussed as pathogenic factors. The results of fine needle biopsy, radiologic examination including CT and ultrasonography, as well as bacteriological cultures are described. The therapy was surgical in both cases.
A consecutive series from two university hospitals of 50 patients with giant cell tumors was reviewed and histologically reconfirmed. The patients treated with curettage and acrylic cement were re-examined concerning function. Two of 14 cemented tumors had recurred but could be treated by additional cementation, so that no final failure of this method had occurred, compared to one of 19 radically resected and 12 of 22 with bone-graft after curettage. Joint function was normal in 11 and radiographic arthrosis of low grade was found in only two of 14 patients. It is concluded that this method gives a minimum of recurrence and a maximum of function. It is suggested that the old name of "giant cell sarcoma" should be reintroduced, bringing the tumor into the group of low-grade sarcomas where it belongs.