Search PubMed⌕ Search

Biomedical subjects

B M Jakobsen

Publications and source records attributed to B M Jakobsen.

13 recordsLinked to original sources

Exposure scenarios and guidance values for urban soil pollutants.

In general, risk assessments of urban soil pollution are prepared by comparing the levels of pollutants with soil quality criteria. However, large urban areas are contaminated with concentrations of pollutants far exceeding the existing soil quality criteria and would consequently be considered to be of potential risk to humans. This is, however, a rather rigid approach, and for risk management purposes it would be desirable to have more than just one level of soil quality criteria. Therefore, a generic risk assessment model was developed for five different use scenarios: child-care centers, kitchen gardens, ornamental gardens, parks, and sports grounds. In each of the scenarios, three different types of expected behavior are described for children and adults, respectively, resulting in different levels of exposure to the pollutants. For risk management purposes, various guidance values can then be derived for each use scenario. Below a lower guidance value, a free use of the area according to the defined use is possible without an unacceptable risk to the public. Above an upper value, a cutoff of the exposure is necessary. In between, the use may be regulated by different types of advice. The model is still preliminary but was, however, used for derivation of guidance values for five commonly found soil pollutants, of which the results for benzo[a]pyrene and lead are presented.

Adult↗

Prenatal toxicity of xylene inhalation in the rat: a teratogenicity and postnatal study.

Technical xylene (cas. nr. 1330-20-7) was investigated for development toxicity in a teratology and in a postnatal study. Rats (Mol: WIST) were exposed to 500 p.p.m. 6 hr per day on days 4 to 20 of gestation. There were no signs of maternal toxicity. In the teratology study, no exposure-related differences were found except for delayed ossification of os maxillare. In the postnatal study, the xylene-exposed pups had a higher body weight and an impaired performance on a motor ability test (Rotarod). Due to the possibility of direct toxic effects of xylene on the developing central nervous system, further studies are needed to investigate dose-effect relationship for this type of effects.

Abnormalities, Drug-Induced↗

[Lung cancer].

Explore the source record for details and available documents.

Humans↗