Immunomodulatory activity of Panax ginseng extract.
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Biomedical subjects
Publications and source records attributed to B M Gupta.
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Hexagonal virus-like particles (VLPs) measuring 45 nm across were detected in mycelial extracts from Trichothecium roseum Himachal strain, the source fungus for the production of T-poly (Trichothecium polysaccharide), a known inhibitor of plant viruses. VLPs were found to contain double-stranded RNA (ds RNA) and the purified ds RNA was capable of inhibiting tobacco mosaic virus infection in Nicotiana glutinosa plants. Active preparations of T-poly were found to contain traces of ds RNA, probably of mycoviral origin.
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An in vitro technique was developed to characterize the intermittent flume patterns associated with the short bursts of metered-dose aerosols. Two orthogonal video images are utilized to describe the complex shape and direction of the flume pattern. This technique facilitates the evaluation of components manufactured by different suppliers.
Electronmicroscopic observations indicate that bacteriophage CVX-5 has an angular head with long spiral tail which is noncontractile, possibly having 2--3 tail fibres attached at the distal part of the tail. This phage is antigenically unrelated to any of the T-phages. Inhibition of phage CVX-5 multiplication by mitomycin C and incorporation of 3H-thymidine into this phage indicate that phage CVX-5 is a DNA phage.
Thirty-six cases of empyema were diagnosed in children over a two year period, giving an overall incidence of 0.11% of the total hospital admissions. Many of them had measles bronchopneumonia and most were malnourished. 16 children had penicillin resistant staphylococcal infection. 29 of them were treated with closed tube drainage. Thirteen died during the course of treatment, the majority within three days of admission. The rest were followed up over a period of up to six months and showed good recovery. Six of these patients developed pneumothorax during the course of treatment. Various combinations of Ampicillin, Cloxacillin, Gentamycin and Cotrimoxazole parenterally were used. Supportive treatment with blood transfusion was found to be beneficial.
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Three hundred and sixty malnourished children were admitted to one of the units of the Children's Hospital, UTH, Lusaka, in 1975. They were studied in an effort to determine the effects of various social, economic and feeding habits in the evolution of PCM. Malnutrition was found in 9.1% of the total admissions and was associated with a high immediate mortality (26.6%). The majority of children were in the 7 months to 24 months age-group. The majority of families were unitary and small, with a high level of illiteracy and from the slums of Lusaka. Breast feeding was a general rule in spite of the urban status of most families. The study showed that the major factors which contributed to malnutrition were poverty and faulty weaning foods. Results were compared with other studies in Africa and India. Incidence of malnutrition can be reduced by increasing the economic level of the community and improving basic health services.
One-thousand single live-born infants were examined and 111 were found to have low birthweight (2500 g or less). Assessment of maturity was made by using physical and neurological criteria without knowledge of when the last menstrual period occurred. The incidence of prematurity among all single live births was 4.5% by physical and 4.9% by neurological criteria and among low birthweight babies it was 40.6% and 44.2% respectively. Both the criteria were found to be equally reliable but physical signs are recommended for routine clinical use because of their simplicity.
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Two hundred and fifty children, suffering from measles were studied for morbidity and mortality in Tanga District Hospital in Tanzania. The highest incidence of measles was in the second half of the first year of childhood (40%). Mortality was directly related to the nutritional status and associated complications. Medical care at the health centre level by medical auxiliaries during the acute phase and the problem of poor weight gain on follow-up are discussed.
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