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Biomedical subjects

B M Fung

Publications and source records attributed to B M Fung.

43 records · Page 3Linked to original sources
PubMed1974

Biological, proton-magnetic-resonance- and ultraviolet-spectroscopic evidence for a molecular complex of actinomycin D and 10,11-dihydro-3H-naphth (1,2-g)indazol-7-ol.

A proton-magnetic-resonance study of the complex formed between actinomycin D and 10,11-dihydro-3H-naphth[1,2-g]indazol-7-ol strongly suggests that the indazole lies above the phenoxazine ring of actinomycin D. The complex can be destroyed by addition of dimethyl sulphoxide or dimethylformamide. The actinomycin D-indazole complex inhibits growth of Pseudomonas fluorescens and raises the thermal denaturation response of DNA. These data support the hypothesis that a molecular complex is formed which readily inhibits cell growth and interacts with DNA.

Chemical Phenomena↗
PubMedDate not supplied

Filtering of spinning sidebands in 1D MAS NMR spectra.

Spinning sidebands (SSBs) in the MAS NMR spectrum of a polycrystalline solid are related to the principal values of the chemical shift or quadrupole coupling tensors. At present, 2D methods are widely used to sort out the SSBs for each isotropic peak. Here a simple and efficient method for separating the SSBs in 1D MAS NMR spectra is described. It is based on finding the optimal spinning rate with a mathematical algorithm and subsequently treating the spectra with filtering functions.

Journal Article↗