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Biomedical subjects

B Lynn

Publications and source records attributed to B Lynn.

68 records · Page 4Linked to original sources
PubMed1973

Intravenous infusions of heparin and penicillins.

The chemical stability and anticoagulant activity of heparin (20 U/ml) were studied in five intravenous fluids at room temperature. Heparin remained stable and active for 24 hours in normal saline, but there was a rapid inactivation of 40 to 55% in solutions containing dextrose or lactate, as measured by chemical and biological methods.High concentrations of benzylpenicillin, ampicillin, or methicillin had no effect on heparin activity in normal saline or dextrose 5%: nor was the stability of the penicillins in these fluids affected to any marked extent by the presence of heparin. Ampicillin was, however, found to be unstable in dextrose 5%, and it would be preferable for it not to be added to dextrose infusions. It is concluded that heparin may be given intravenously in normal saline with benzylpenicillin, ampicillin, or methicillin but several other antibiotics were found to be unsuitable for concurrent infusion with heparin.

Ampicillin↗
PubMed1971

The form and distribution of the receptive fields of Pacinian corpuscles found in and around the cat's large foot pad.

1. Firing thresholds of Pacinian corpuscles situated within or close to the large pad of the cat's hind foot have been determined following step displacements applied to various points on the pad surface.2. The most sensitive positions on the receptive fields of thirty-one corpuscles were distributed unevenly over the pad. About half were situated close to the interlobular crease lines, and most of the others were at the edge of the pad.3. Threshold receptive fields were usually of complex form, with more than one region of low threshold.4. The approximate locations of a number of Pacinian corpuscles whose fields had been mapped were determined by dissection.5. The most sensitive position on the pad was usually at the closest point to the corpuscle. If the corpuscle was situated outside the pad itself, it was therefore usually most easily excited from some point at the edge of the pad. However, a minority of Pacinian corpuscles were most easily stimulated from some region other than that closest to them.6. It is suggested that previous estimates of the ability of this population of receptors to transmit information about the positions of stimuli (Gray, 1966) must be re-evaluated in the light of the non-uniform distribution and asymmetry of their cutaneous receptive fields.

Action Potentials↗
PubMed1969

The nature and location of certain phasic mechanoreceptors in the cat's foot.

1. The locations of the receptor endings of twenty-two phasic, primary afferent units which could be excited by small (less than 40 mum) point displacements of cats' large foot pads have been determined by dissection.2. Eleven of these units had endings located within or immediately below the skin on the plantar surface of the pad; eight had endings located deep within the pad and three had endings on the digits.3. All the deep and digital endings were of the PC type of Jänig, Schmidt & Zimmermann (1968) whilst five of the superficial endings were definitely of the RA type of Jänig et al. (1968), and another five could have been. One superficial ending had properties intermediate between those of RA and PC receptors.4. It was shown by dissection that the endings of four of the PC type units were Pacinian corpuscles and such corpuscles were seen within 1 mm of the apparent location of six other PC receptors. Pacinian corpuscles were found close to only two of the eleven superficial receptor locations.5. It is therefore concluded that of the two functionally distinct types of phasic receptors studied, the PC receptors are Pacinian corpuscles located deep in the pad or on the digits, whilst the RA receptors are located within or immediately below the skin and are not Pacinian corpuscles.

Animals↗