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B Lo

Publications and source records attributed to B Lo.

At least 37 records · Page 2Linked to original sources
PubMed1991

Beyond the Cruzan case: the U.S. Supreme Court and medical practice.

In a landmark decision, the U.S. Supreme Court affirmed a Missouri ruling that sharply limited family decisions about life-sustaining treatment for incompetent patients. The Court held that the Constitution protects the refusal of life-sustaining treatment by competent patients. For incompetent patients, states may require "clear and convincing" evidence of refusal, specifically for the withdrawal of tube feedings, if such a person were in a persistent vegetative state. The ruling left many clinical questions unanswered, such as whether life-sustaining treatment must be given to terminally ill incompetent patients, whether patients may refuse artificial feedings, and what constitutes clear and convincing evidence of refusal. The decision also has potentially harmful consequences. It may undermine family decision making, encourage cynicism and disregard of the law, and promote defensive medicine. Physicians can minimize such consequences by encouraging patients to provide advance directives, such as the durable power of attorney for health care, by urging legislative action, and by setting national practice standards for decisions regarding incompetent patients.

Adult↗
PubMed1991

Do house officers learn from their mistakes?

Mistakes are inevitable in medicine. To learn how medical mistakes relate to subsequent changes in practice, we surveyed 254 internal medicine house officers. One hundred fourteen house officers (45%) completed an anonymous questionnaire describing their most significant mistake and their response to it. Mistakes included errors in diagnosis (33%), prescribing (29%), evaluation (21%), and communication (5%) and procedural complications (11%). Patients had serious adverse outcomes in 90% of the cases, including death in 31% of cases. Only 54% of house officers discussed the mistake with their attending physicians, and only 24% told the patients or families. House officers who accepted responsibility for the mistake and discussed it were more likely to report constructive changes in practice. Residents were less likely to make constructive changes if they attributed the mistake to job overload. They were more likely to report defensive changes if they felt the institution was judgmental. Decreasing the work load and closer supervision may help prevent mistakes. To promote learning, faculty should encourage house officers to accept responsibility and to discuss their mistakes.

Analysis of Variance↗
PubMed1990

Informing physicians about promising new treatments for severe illnesses.

Physicians are increasingly informed of promising new treatments for severe illnesses through unconventional communications such as press releases, press conferences, and direct mailings. These highly publicized announcements disseminate information quickly, often many months before new data are presented at medical meetings or published in peer-reviewed medical journals. Such unconventional communications, however, usually do not provide sufficient detail for physicians to evaluate new studies, answer patients' questions, or make recommendations. We suggest that physicians would be better informed about therapeutic advances through (1) expanded information in unconventional communications, (2) increased availability of information from the Food and Drug Administration, (3) early submission and accelerated review of key medical journal articles, and (4) expanded use of on-line computerized information sources. A commitment to inform physicians better about promising new treatments may help save or prolong the lives of patients with severe illnesses.

American Medical Association↗
PubMed1990

Withholding and withdrawal of life support from the critically ill.

We investigated decisions to withhold or withdraw life support from patients in the medical-surgical intensive care units at the Moffitt-Long Hospital of the University of California and San Francisco General Hospital, from July 1987 through June 1988. Among 1719 patients admitted to the two intensive care units, life support was withheld from 22 (1 percent) and withdrawn from 93 (5 percent). The reason for limiting care was poor prognosis. Of these 115 patients (18 of whom were considered brain-dead), 89 died in the intensive care unit (accounting for 45 percent of all deaths there), and all but 1 of the remaining patients died after transfer from the intensive care unit. Thirteen (11 percent) had earlier expressed the wish that their terminal care be limited, but this affected care in only four cases. Only 5 of the 115 patients made the actual decision to limit care; the others were incompetent at the time. Of the latter, 102 had families who participated in the decision; family members of the other 8 incompetent patients could not be found, and the decisions were made by physicians. Only 10 families initially disagreed with the recommendations to limit care, and they later agreed. The median duration of intensive care among the patients from whom life support was withheld or withdrawn was eight days at Moffitt-Long Hospital and four days at San Francisco General, as compared with medians of three and one days, respectively, for other patients who died in the intensive care units. We conclude that although life-sustaining care is withheld or withdrawn relatively infrequently from patients in the intensive care unit, such decisions precipitate about half of all deaths in the intensive care units of the hospitals we studied. In most of these cases the patients are incompetent, but physicians and families usually agree to limit care.

Adult↗
PubMed1990

Many people who seek anonymous HIV-antibody testing would avoid it under other circumstances.

Decreases in high-risk behavior have been observed when people have sought anonymous or confidential HIV-antibody testing accompanied by counseling. HIV-antibody testing also benefits those who are tested, since people who find that they are seropositive can receive closer medical follow-up, and, in certain cases, medical treatment. However, debates continue about appropriate testing policy. This study concerns the conditions under which people who are currently seeking anonymous testing at an alternative test site would be willing to obtain testing. On self-administered questionnaires all sexual orientation/gender groups expressed reluctance to obtain testing if anonymity were not assured. Bisexual men were especially concerned about seeking testing if there was mandatory reporting. Believing that one was infected with HIV was slightly associated with a decreased inclination to obtain testing under non-anonymous circumstances.

Acquired Immunodeficiency Syndrome↗
PubMed1990

Ethical dilemmas in HIV infection.

As the AIDS epidemic continues to claim lives, the issues of testing, confidentiality, and refusal to care for seropositive patients generate increasing debate and concern among health care workers, legislators, and the general public. Protecting the uninfected from exposure to HIV, providing adequate medical care and counseling to HIV-positive persons, and preventing discrimination are necessary and immediate goals. Adherence by practitioners to both the current legislation on AIDS and the ethical imperatives of the health professions will facilitate adequate access to health care for all persons with AIDS. It will also provide necessary guidelines for issues of confidentiality.

Acquired Immunodeficiency Syndrome↗
PubMed1990

Counseling patients seropositive for human immunodeficiency virus. An approach for medical practice.

Persons at risk for infection with the human immunodeficiency virus are being encouraged to learn their serostatus. While such knowledge can help patients seek appropriate medical care, it can also be distressing. We describe an approach, based on crisis counseling, for physicians to use in working with patients infected with HIV. It can help physicians in assisting patients with emotional reactions to the diagnosis as well as in directing patients to manage practical issues of concern. Methods for discussing safer sex or injection practices are also presented.

Adaptation, Psychological↗
PubMed1989

Decisions about resuscitation: inequities among patients with different diseases but similar prognoses.

STUDY OBJECTIVE: To assess whether decisions about "do-not-resuscitate" (DNR) orders are made equitably in patients with different diseases but similar prognoses. DESIGN: Retrospective cohort study. SETTING: Three teaching hospitals: a university referral center, a county hospital serving a largely indigent population, and a Veterans Administration hospital. PATIENTS: Consecutive patients with any of the four following discharge diagnoses: the acquired immunodeficiency syndrome (AIDS) (100 patients); unresectable non-small-cell lung cancer (51 patients); cirrhosis with esophageal varices (51 patients); and severe congestive heart failure with coronary artery disease (115 patients). MEASUREMENTS AND MAIN RESULTS: Do-not-resuscitate orders were written for 52% of patients with AIDS and 47% of patients with cancer but for only 16% of patients with cirrhosis and 5% of patients with congestive heart failure (P less than 0.0001). Although DNR orders were associated with functional and mental status, reason for admission, and severity of illness, the strong association between DNR orders and disease category persisted after adjustment for these potential confounders by multiple logistic regression. A survey of housestaff showed that DNR orders were discussed more frequently with patients who had AIDS or lung cancer than with patients who had cirrhosis or heart failure, despite an accurate understanding of the generally similar prognoses among the four groups. CONCLUSIONS: Despite relatively similar prognoses, patients with AIDS or lung cancer are much more likely to receive DNR orders than patients with cirrhosis or severe congestive heart failure. This discrepancy cannot be explained by differences in severity of illness among patients or by misunderstandings of prognosis by clinicians. From our data, we cannot determine if patients with cirrhosis or heart failure receive too few DNR orders or if patients with AIDS or lung cancer receive too many. Our findings should encourage physicians to determine the preferences of patients about life-sustaining treatments more equitably.

Acquired Immunodeficiency Syndrome↗
PubMed1989

Voluntary screening for human immunodeficiency virus (HIV) infection. Weighing the benefits and harms.

Voluntary screening for human immunodeficiency virus (HIV) infection may help prevent the spread of the HIV epidemic if persons who test positive alter behaviors that may transmit infection. Protecting persons from unknowingly being exposed to HIV infection must be balanced against respecting the autonomy of individuals being screened. Seropositive patients may feel a stigma and be subjected to discrimination if confidentiality of test results is breached. In patients without high-risk behaviors, the positive predictive value of HIV testing may be substantially increased if tests are done in reference laboratories and if further confirmatory tests are run on a second blood specimen. For persons with high-risk behaviors, HIV testing can be recommended to those who want to reduce uncertainty about their HIV status or whose medical care would change if they were seropositive. Health care workers can maximize benefits of screening and minimize harm by educating and counseling patients before HIV testing, discussing the confidentiality of HIV test results, urging patients to disclose positive test results to sex partners, and advising patients on how to reduce high-risk behaviors.

Acquired Immunodeficiency Syndrome↗
PubMed1989

The physician's responsibility toward hopelessly ill patients. A second look.

Physicians have a specific responsibility toward patients who are hopelessly ill, dying, or in the end stages of an incurable disease. In a summary of current practices affecting the care of dying patients, we give particular emphasis to changes that have become commonplace since the early 1980s. Implementation of accepted policies has been deficient in certain areas, including the initiation of timely discussions with patients about dying, the solicitation and execution in advance of their directives for terminal care, the education of medical students and residents, and the formulation of institutional guidelines. The appropriate and, if necessary, aggressive use of pain-relieving substances is recommended, even when such use may result in shortened life. We emphasize the value of a sensitive approach to care--one that is adjusted continually to suit the changing needs of the patient as death approaches. Possible settings for death are reviewed, including the home, the hospital, the intensive care unit, and the nursing home. Finally, we consider the physician's response to the dying patient who is rational and desires suicide or euthanasia.

Ethics, Medical↗
PubMed1989

Community-acquired bacteremia in patients with acquired immunodeficiency syndrome: clinical presentation, bacteriology, and outcome.

PURPOSE: Community-acquired bacteremia is an easily treatable infection occurring in patients with acquired immunodeficiency syndrome (AIDS). Although other studies have reported bacterial infections in AIDS patients, none have clearly described the clinical presentation of these patients. In this survey, we sought to define how frequently AIDS patients presented to our institution with community-acquired bacteremia; which organisms and sources of bacteremia were involved; the frequency that these patients presented with abnormal vital signs and white blood cell counts; and the in-hospital outcome of these patients. PATIENTS AND METHODS: We retrospectively identified patients with AIDS hospitalized at San Francisco General Hospital in the 16 months between August 1986 and December 1987 in whom a positive blood culture was drawn within 24 hours of admission. Each of the patient's charts was reviewed for demographic data, relevant past medical history, clinical admission information, laboratory data, and discharge status. RESULTS: We identified 44 episodes of community-acquired bacteremia in 38 patients with AIDS. These episodes represented approximately 5% of the admissions of patients with AIDS. The patients were young (mean age, 38 +/- 7 years), homosexual (43 of 44), and in some cases intravenous drug users (nine of 44). On admission, only 57% of the patients were febrile (temperature greater than 38.3 degrees C) and 23% of the patients presented with normal vital signs. Twenty-seven percent were neutropenic (less than 1,000 neutrophils/mm3). The most common sources of the bacteremia were pneumonia (10), an indwelling central venous line (eight), and cellulitis (seven). A total of 14 patients had no apparent source. Staphylococcus aureus, Streptococcus pneumoniae, and Escherichia coli were the most common organisms. Only four of the 44 patients died during their hospitalization. CONCLUSION: We conclude that patients with AIDS and community-acquired bacteremia can present to the hospital without abnormal vital signs or white blood cell counts. Clinicians cannot depend on these data to assist them in excluding the possibility of bacteremia in patients with AIDS. In addition, due to the variety of organisms found in our survey, we recommend that broad-spectrum antibiotics should be the empiric therapy in patients with a suspected bacterial infection.

Acquired Immunodeficiency Syndrome↗
PubMed1989

Life-sustaining treatment for patients with AIDS.

Physicians increasingly are being called upon to make difficult decisions about intensive care for patients with the acquired immunodeficiency syndrome (AIDS). AIDS patients who require intensive care have a poor prognosis; the in-hospital mortality rate of those receiving mechanical ventilation for P carinii pneumonia is 86-100 percent in most studies. However, in the past year, two studies documenting improved outcome have been published. Physicians should understand these outcome data and use well-established ethical principles to allow informed competent patients with AIDS to express their preferences regarding intensive care. Patients should be encouraged to provide advanced directives regarding life-sustaining treatments or to designate surrogate decision-makers to be consulted should they lose mental competence. The health care system should provide alternatives to the ICU for compassionate terminal care. However, arbitrary policies denying intensive care to AIDS patients for whom it is medically indicated and desired are not warranted.

Acquired Immunodeficiency Syndrome↗
PubMed1989

To tell or not to tell: the ethical dilemmas of HIV test notification in epidemiologic research.

Epidemiologic studies involving HIV (human immunodeficiency virus) antibody testing create ethical dilemmas, particularly about notifying asymptomatic seropositive subjects. Four study designs address this problem: mandatory notification, optional notification, anonymous testing, and blind testing. No single design consistently optimizes the trade-off between valid and ethical research. Each strategy differs substantially from the others in its effect on response rates, bias, ability to perform longitudinal studies, numbers of subjects who learn their test results, and the number of subjects counseled about HIV risk reduction. Both local institutional review boards and potential subjects of study (and their sexual partners) should participate in decisions regarding the conduct of sensitive AIDS (acquired immunodeficiency syndrome) research.

Epidemiologic Methods↗