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Biomedical subjects

B Levy

Publications and source records attributed to B Levy.

At least 217 records · Page 12Linked to original sources
PubMed1971

Selective blockade of the vasodepressor response to prostaglandin F 2 in the anaesthetized rabbit.

1. The prostaglandin-blocking activity of meclofenamic acid, N-(2,6-dichloro-m-tolyl)anthranilic acid (CI-583), was analysed in the anaesthetized rabbit. PGF(2alpha), PGE(1) and isoprenaline were injected before and after meclofenamic acid infusion.2. Isoprenaline produced a fall in blood pressure, a reduction in oviduct motility and a reduction in uterine motility if the uterus showed marked spontaneous motility. PGF(2alpha) uniformly produced a fall in blood pressure and an increase in both uterine and oviduct contractility. PGE(1) produced a fall in blood pressure, a reduction in oviduct motility and no consistent effect on uterine motility.3. Meclofenamic acid selectively blocked the vasodepressor response to PGF(2alpha). The vasodepressor responses to PGE(1) and isoprenaline as well as the effects of all three agonists on uterine and oviduct contractility were not reduced by treatment with meclofenamic acid.4. Polyphloretin phosphate (PPP) administered to two rabbits in a cumulative dose of 94 mg/kg showed no significant blocking action on the vasodepressor or uterine and oviduct contractor responses to PGE(1) or PGF(2alpha) though this compound, like meclofenamic acid, has been reported to antagonize the actions of PGE(1) and PGF(2alpha) on isolated smooth muscle preparations.

Animals↗
PubMed1970

1-Isopropylamino-3-(4-indanoxy)-2-propanol HC1: a potent beta-adrenoreceptor antagonist.

1. The beta-adrenoceptor blocking activity of 1-isopropylamino-3-(4-indanoxy)-2-propanol HCl (USVC 6524) was determined in the anaesthetized dog, the isolated rat uterus and the isolated guinea-pig tracheal strip.2. USVC 6524 inhibited the positive inotropic, positive chronotropic and vasodilator responses to isoprenaline in the dog in a dose of 10 mug/kg and higher. On the basis of comparative pA(2) values, USVC 6524 is approximately 10 times more potent as a beta-adrenoceptor antagonist than propranolol.3. Cardiac depressant effects produced by USVC 6524 were relatively mild and occurred only after the onset of a strong beta-adrenoceptor blockade.4. USVC 6524 also blocked beta-adrenoceptors in the isolated rat uterus and guinea-pig tracheal spiral strip.

Adrenergic beta-Antagonists↗
PubMed1968

Variation in the oncogenic potential of human adenoviruses carrying a defective SV40 genome (PARA).

The acquisition of the defective SV40 genome by a variety of human adenovirus serotypes by the process of transcapsidation has resulted in the addition of oncogenic potential for newborn hamsters to the previously nononcogenic adenovirus types 1, 2, 5, and 6. These serotypes have previously been grouped together by the high GC content of their DNA. Transcapsidation of the SV40 genome to weakly oncogenic adenovirus types 3, 14, 16, and 21 has failed to increase their oncogenic potential although the parent adenovirus type 7 carrying PARA is highly oncogenic. These serotypes belong to the group possessing a DNA of intermediate GC content. All the PARA-adenovirus populations, even those that were nononcogenic, were able to induce SV40 transplantation immunity and therefore carry the SV40 transplantation marker as well as the marker for synthesis of SV40 tumor or T antigen.

Adenoviridae↗
PubMed1968

The potentiation of rat uterine inhibitory responses to noradrenaline by theophylline and nitroglycerine.

1. Dose response curves for noradrenaline were determined before, during and after pretreatment with a variety of agents. The inhibitory response to noradrenaline on the isolated rat uterus was measured according to its ability to inhibit an acetylcholine induced contraction.2. Theophylline, an agent that inhibits phosphodiesterase and increases cyclic AMP levels in the rat, potentiated the response to noradrenaline.3. Pretreatment with cocaine had no significant effect on the potentiation of the noradrenaline response by theophylline.4. Theophylline potentiated the inhibitory response to nitroglycerine.5. Pretreatment with nitroglycerine also potentiated the inhibitory response to noradrenaline.6. Theophylline appears to produce a potentiation of the inhibitory effect of noradrenaline on the rat uterus by means of a non-specific mechanism.

Animals↗