Biomedical subjects
Publications and source records attributed to B Letot.
We studied by immunohistochemistry three cases of delayed envenomation by coelenterates. The most prominent features were the grouping of human leukocyte antigen-DR-positive cells with Langerhans cells (S-100 positive) and helper/inducer T lymphocytes (Leu-1+, Leu-3+, and Leu-4+). This indicates the possibility of a type IV immunoreaction in the delayed cutaneous lesions caused by coelenterates.
Many coelenterates can injure human skin by means of their nematocytes. Our study was based upon clinico-pathological confrontations and was also conducted in vitro with sea anemones. Most acute reactions were toxic in nature and induced sublethal and lethal alterations of the keratinocytes with swelling of their cytoplasms and pyknosis. Another reaction found in 1 patient revealed an acantholytic disruption of the epidermis associated with intercellular deposits of IgG. These lesions were different from the late or recurrent reactions to coelenterates.
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