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Biomedical subjects

B Lembcke

Publications and source records attributed to B Lembcke.

121 records · Page 7Linked to original sources
PubMed1985

Small intestinal function in chronic relapsing pancreatitis.

In a prospective study, several parameters of small intestinal function have been assessed in 20 patients with chronic relapsing pancreatitis with and without steatorrhoea. By and large all routine parameters of small intestinal function were found to be normal. In particular, neither a previously reported high incidence of lactase deficiency, nor D-xylose malabsorption or vitamin B12 depletion was observed. However, there was a high incidence of abnormal 14C-cholylglycine breath tests (40%), suggesting the presence of mild bacterial overgrowth. Occasionally, this condition was associated with diarrhoea and steatorrhoea, thus indicating that steatorrhoea remaining after high-dosage pancreatin supplementation might sometimes be due to bacterial overgrowth.

Alcoholism↗
PubMed1984

Role of gastrointestinal transit in the delay of absorption by viscous fibre (guar).

The influence of guar gum on gastric emptying of liquids in healthy volunteers and on mouth-to-caecum transit time in controls and partially gastrectomized patients has been studied. Together with a flattening effect on blood glucose profiles after a liquid glucose load, guar significantly delays mouth-to-caecum transit time both in healthy controls and partially gastrectomized patients. The retardation of transit is not explicable by a delay in gastric emptying, as can be shown by means of an isotope technique. Only in "quick starters' was a delay in initial gastric emptying observed. The exponential phase of gastric emptying remained unaffected. Moreover, it is shown that the prolongation of mouth-to-caecum transit time is not mediated by factors operating at the level of the pyloricantral region. Delayed small-bowel passage by guar might modulate absorption of glucose by increasing the unstirred layer resistance and, in the non-steady state, by limiting the absorptive area initially covered by a bolus.

Adult↗
PubMed1983

A new class of inhibitors for in vitro small intestinal transport of sugars and amino acids in the rat.

Polycationic compounds like polylysine, protamine or polyethylenimine may interfere with a cation-related membrane transport system depending on superficially accessible binding sites for particular cations. In vitro experiments were performed using either everted segments of rat small intestine to measure tissue accumulation or everted sacs to determine mucosal-to-serosal transport. The effect of polycations was also tested using brush-border membrane vesicles of rat jejunum. Polycations inhibited the tissue accumulation of methyl alpha-D-glucoside as well as binding of phlorizin. Inhibition of accumulation was increased by raising the polycation concentration and by preincubation of the tissue with the polycations. Kinetic experiments revealed a competitive type of inhibition for the uptake of neutral amino acids and actively transported sugars. Using everted sacs to compare the monomeric cations with their corresponding polymeric forms for their inhibitory effect, it was found that only polymers applied to the mucosal compartment impaired active transport. The passive diffusion of solutes, e.g. 2-deoxy-D-glucose or mannitol, was slightly increased by polycations. With some intermediate oligomers of lysine it could be shown that more than 20 cationic groups are required for approximate complete inhibition. That membrane-related events are responsible for the observed inhibition is suggested by the reduced uptake of D-glucose by brush-border membrane vesicles in the presence of polycations. Therefore an interaction with transport-related cation binding sites, i.e. anionic residues, at the mucosal surface may be assumed.

Animals↗
PubMed1983

[Transmural gastric potential difference (PD) and intragastric diurnal pH profile with proglumide].

The presented double-blind cross-over-study evaluates the effect of proglumide on gastric potential difference (PD) and the PD-response to irritation of the gastric mucosal barrier by acetylsalicylic acid (ASA). Both, in an acute and a 6-day trial, no protective effect against the mucosal barrier breaker ASA was noticed. Furthermore, the 6-day administration of proglumide neither changed the 23-hour gastric pH-profiles nor the postprandial course of intragastric pH. The findings are shown in contrast to the action of cimetidine. The study shows, that proglumide neither reduces the aggressive factor acidity nor works protective at the gastric mucosal barrier.

Adult↗
PubMed1983

[Simplified methods of expiratory hydrogen (H2) analysis--clinical testing of two H2 breath test devices].

Clinical application of two devices available for breath hydrogen (H2) analysis in the gastroenterologist's or hospital practice was investigated. Breath H2 analysis by gaschromatography was used as reference method. Apparatus A was inadequate for measurements of H2 concentrations in endexpiratory air. With the second apparatus (B) valid measurements were obtained. Both, sensitivity and precision suggest that this device may be an alternative for gaschromatographic H2 analysis which will be suitable for the clinical and practising gastroenterologist's purposes.

Breath Tests↗
PubMed1982

Influence of metronidazole on the breath hydrogen response and symptoms in acarbose-induced malabsorption of sucrose.

The influence of metronidazole on the breath hydrogen response and symptoms of sucrose malabsorption was investigated in a double-blind, randomized and controlled study. Carbohydrate malabsorption was induced by the competitive alpha-glucosidase inhibitor, acarbose. Metronidazole reduced flatulence and the breath hydrogen response during sucrose malabsorption without a change in intestinal carbohydrate absorption, as indicated by serum levels of gastric inhibitory polypeptide, serum insulin and blood glucose. The effect of metronidazole suggests that anaerobic bacteria mediate both signs and symptoms of the colonic response to sucrose malabsorption. In contrast to previous reports on lactose malabsorption, it was not possible to quantify sucrose malabsorption by comparing the breath hydrogen response to sucrose malabsorption with the H2 response to a lactulose load.

Acarbose↗
PubMed1982

Plasma digoxin concentrations during administration of dietary fibre (guar gum) in man.

The effect of guar gum on digoxin absorption was investigated in eleven healthy volunteers. The drug was administered in the morning during two five-day-periods, together with a liquid mixed test meal (+/- 18 g guar). By measuring plasma digoxin concentrations no differences were registered between the control and guar gum period. It is concluded that long-term administration of guar gum will not interfere with adequate digitalization (digoxin bioavailability).

Administration, Oral↗
PubMed1980

Different actions of neomychin and metronidazole on breath hydrogen (H2) exhalation.

Purpose of this investigation was to characterize the effect of antibiotics as a possible limiting factor for the evaluation of hydrogen (H2) breath analysis tests which depend on bacterial carbohydrate fermentation. Breath H2-excretion following ingestion of the non-absorbable disaccharide lactulose was monitored in healthy subjects before and after pretreatment with the aminoglycoside neomycin or with metronidazole. Metronidazole decreased the amount of hydrogen exhaled by 39 % (p<0.05) and peak H2-excretion by 42.1 % (p<0.01), because it suppresses anaerobe H2 producing microorganisms. Neomycin intensified nonsignificantly the integrated (0-6 hours) breath hydrogen response to lactulose (+43 %) and the maximal H2-concentration by 29.8 %, probably because it interferes with intestinal bacteria which are important for H2-consumption.

Adult↗