[Hemodynamic effects of spleen contractions in cases of splenomegaly].
Explore the source record for details and available documents.
Hemodynamics↗
Biomedical subjects
B Leijnse
Publications and source records attributed to B Leijnse.
Depression, glucose tolerance, peripheral glucose uptake and their alterations under the influence of anti-depressive drugs of the hydrazine type.
Explore the source record for details and available documents.
Adult↗
Are definitive (reference) methods and Shewhart's principle the best approach towards accuracy?
The current state of quality control in clinical chemistry cannot be characterized as good; the appropriate description is acceptable. This statement is illustrated by results from quality control programmes. The influence of the matrix in which the analyte is embedded points to serious analytical deficiencies in the methods used in clinical chemistry. The abundant application of statistics is criticized and it is argued that such application can be avoided by improving the accuracy and precision of the analytical methods. Difficulty in defining a definitive method results from accuracy and 'true value' not being determinate. The approved IFCC definition of the reference method and the connection between this definition and the basis of quality control in clinical chemistry is discussed. The pioneering work of Shewhart on quality control in industry in the 1930s is revealed. It is pointed out that the main principle of this method, a continuous process of tracing and eliminating assignable sources of variation, should be the aim of quality control in clinical chemistry.
Blood Chemical Analysis↗
A multi-dimensional analysis of three chemical quantities in the blood.
A three-dimensional model for the analysis of the three quantities pH, pCO2 and base excess (BE), as measured in arterial blood, is presented. Whereas the conventional analysis of these quantities relies on reference regions as established from the univariate distributions, treating the quantities as uncorrelated, the present model estimates the parameters of the three-dimensional reference region from a sample of observations, based on the assumption that the observations inside the reference region follow a multi-dimensional Gaussian distribution. For observations outside the reference region, reference directions are established, corresponding to the conventionally defined specific states of acid-base disturbances. This leads to a new classification model, the results of which are compared to those of the conventional model.
Acid-Base Equilibrium↗