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Biomedical subjects

B Lebel

Publications and source records attributed to B Lebel.

At least 73 records · Page 4Linked to original sources
PubMed1976

[Sensitization to penicillin following cutaneous side-effects of ampicillin].

Sensitization to penicillin was determined in vitro in twenty subjects, 30 days after cutaneous side-effects due to ampicillin. The study inclued the detection of anti-penicillin IgE, IgM, a lymphoblastic transformation test and a leucocyte migration test. No difference could be demonstrated between the sensitization 30 days after an ampicillin reaction and the sensitization 30 days after a penicillin reaction.

Adult↗
PubMed1976

Lymphocyte transformation, leucocyte migration, specific IgE, IgG and IgM before, during, and after penicillin treatment without adverse reaction. A follow-up study.

This in vitro follow-up study of the penicillin-induced immune response by a well-tolerated regimen was conducted with an association of four tests: lymphocyte transformation test; leucocyte migration test; passive anaphylaxis on monkey lung tissue; and passive hemagglutination. It showed (1) that previously sensitized subjects (including IgE) tolerated the treatment by pencillin. (2) That the treatment induced either a transient positive conversion of previously negative tests or a negative conversion of previously positive tests. These in vitro findings are in accordance with previously established concepts based upon cutaneous tests and must be taken into consideration when interpretating in vitro diagnosis of penicillin allergy.

Adolescent↗
PubMed1976

The penicillin antigens: presentation in the leucocyte migration test (a study with penicillin and penicilloylated proteins).

The response of the leucocyte migration test (LMT) to benzyl penicillin (BP) was compared with the response of LMT to benzyl penicilloylated human gamma globulins (BPO HGG) and to benzyl penicilloylated human serum albumin (BPO HSA). Patients with and without hypersensitivity to penicillins were investigated. No statistical differences were found between the response to BP and to BPO HGG or BPO HSA; this finding supports the fact that the BPO groups generated by BP are mainly implicated in the triggering of the LMT when BP is used as antigen. A strongly penicilloylated HSA appeared to be the most effective mode of the antigen presentation for the detection of BPO-specific cellular immunity in patients with and without clinical symptoms of hypersensitivity to the penicillins.

Adult↗
PubMedDate not supplied

[Limb vasodilation provoked by stimulation of the carotid sinus. Importance of histaminergy in the dog].

The vasodilator reflex induced by baroreceptor stimulation was studied on the hindlimbs of the dog. The reflex was induced by norepinephrine (1 microgram/kg) either by intravenous injection or by direct injection into the carotid sinus. In other experiences, the baroreceptor stimulation was obtained by distension of the sinus by rapid injection of 100 ml of physiological serum. The vascular response was studied by recording the hindlimbs blood flow. One of the limbs was previously pretreated by mepyramine and cimetidine (blockage of histaminergic H1 and H2 receptors). During the first minute after the baroreceptor stimulation, blood samples were collected from the venous blood of hindlimbs for histamine assay (fluorometric assay). Our results show: a much lower vasodilation on the limb pretreated by histamine antagonist, a significant increase during the reflex vasodilation of histamine blood levels measured in the efferent blood of hindlimbs. These results, obtained in experimental conditions as physiological as possible (blood perfusion of the limbs with "natural" hemodynamic parameters) permit to conclude that the vasodilation induced by baroreceptor reflex is at least partially histaminergic in the dog.

Animals↗