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Biomedical subjects

B Larsen

Publications and source records attributed to B Larsen.

345 records · Page 20Linked to original sources

Patellar taping: a radiographic examination of the medial glide technique.

The purpose of this study was to radiographically determine the effectiveness of the McConnell medial glide patellar taping technique. Twenty apparently healthy men, between ages 18 and 35, participated in this study. Subjects underwent a series of three radiographs in a modified Merchant view. First, a bilateral tangential view of the patellofemoral joints was taken to establish a baseline. Next, the same view was obtained with the experimental knees taped using the McConnell medial glide technique. Subjects then underwent a standardized exercise protocol to stress the tape and the accompanying knee structures. This was followed by a third view of the patellofemoral joints. Radiographs were measured using the Merchant congruence angle and analyzed statistically with dependent, mean difference tests. Results from this study indicate that the McConnell medial glide technique was effective in significantly moving the patella medially (P = 0.003), but that the tape was ineffective in maintaining this significance after exercise (P < 0.001). In 3 subjects (15%) of this sample, the tape was ineffective in moving the patella medially in any degree. One interesting finding was that exercise caused a statistically significant (P = 0.016) lateral shift from baseline in the control knees. This may suggest some clinical significance for patellar taping in preventing excessive lateral shift.

Adolescent↗

The effect of estradiol on Candida albicans growth.

The size of colonies growing on Sabouraud's dextrose agar (SDA) supplemented with 1 microM beta estradiol (1,3,5[10]-estratiene-3,17B-diol) was compared to those growing without the estrogen supplement. Data (video pixel counts) were obtained by video capture and image analysis and revealed that yeast strains were not uniformly stimulated by estradiol. One estrogen-responsive strain was evaluated in a chemically defined medium to evaluate growth in the presence of 17-alpha and 17-beta isomers of estradiol. The beta isomer promoted more rapid growth of the test organism and resulted in greater biomass production than the alpha isomer. Understanding of the role of mammalian hormones as growth promoting signals may provide information on this organism's shift from saprophytic to commensal to pathogenic status in vivo. Strain variation in response to estrogen may provide an explanation for differences in virulence.

Candida albicans↗

Inhibitory effects of seven organosulphur compounds on clinical isolates of Candida species in vitro.

Thirty clinical isolates of Candida albicans and 10 other Candida species were tested for susceptibility to 6 substituted dithiocarbamates and one dimercaptosuccinate. Dimethyldithiocarbamate, sodium pyrrolidine dithiocarbamate, and sodium diethyldithiocarbamate showed dose-dependent antifungal activity which was partially reversed by the addition of zinc, copper, or iron sulfate with greatest reversal at 2:1 metal to dithiocarbamate molar ratio. Anaerobiosis also interfered with dithiocarbamate antifungal activity.

Anaerobiosis↗