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Biomedical subjects

B L Aronoff

Publications and source records attributed to B L Aronoff.

23 records · Page 2Linked to original sources
PubMedDate not supplied

Preactivation: a new concept for generation of photoproducts for potential therapeutic applications.

Controlled exposure of photoactive compounds to light prior to their use in biological targets results in the formation of heretofore unknown photoproducts. This process of photoproduct generation, termed preactivation, renders the photoactive compound capable of systemic use without further dependence on light. We have demonstrated that preactivated Merocyanine and preactivated Photofrin-II possess significant antitumor and antiviral activity against certain tumor cells and viruses, while under identical conditions normal cells and tissues are minimally affected. Thus, the preactivation procedure may represent a promising therapeutic modality for controlling systemic malignancies and viral infections.

Animals↗
PubMedDate not supplied

Survey of primary liver tumors and oral contraceptive use.

The American College of Surgeons' survey data on 378 female and 165 male cases of primary liver tumors reported by 477 hospitals in the United States during 1970--1975 are presented. In males, 91.5% of the tumors were malignant, confirming the rarity of benign liver tumors in males. Among females, 43.9% were malignant and 56.1% were benign. Of the 212 benign tumors, 96 were hepatic cell adenomas and 58 were focal nodular hyperplasias. A positive history of oral contraceptive use was found in nearly half of all tumors, 65% of benign tumors, 74% of hepatic cell adenomas, and 74% of focal nodular hyperplasias. High frequencies of benign tumors were observed in the age group 20--30 yr. More than 80% of the tumors in this age group were found in oral contraceptive users. Symptomatology was more severe among users. No case of intraperitoneal bleeding was observed in nonusers. The findings confirm the suggested association between use of oral contraceptives and hepatic cell adenomas and focal nodular hyperplasias.

Adolescent↗
PubMedDate not supplied

Lasers in plastic and general surgery.

Physicians have worked with basic scientists to develop lasers suitable for surgical applications. Because the use of lasers offers improved coagulation and reduced bleeding, applications in surgery have developed rapidly. Plastic surgery and dermatology have realized important advances with the development of laser surgery. The argon laser is commonly used in plastic surgery; the carbon dioxide laser is useful in treating patients with complications such as infections or clotting abnormalities. The CO2 laser is important in cancer surgery, as an adjuvant to liver surgery, and in pancreatic surgery. Photoradiation is an exciting new area of laser use being developed.

Humans↗