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Biomedical subjects

B Kvinesdal

Publications and source records attributed to B Kvinesdal.

26 records · Page 2Linked to original sources
PubMed1986

Quantitative evaluation of iodine-123 hippuran gamma camera renography in normal children.

In a retrospective study of 39 normal children submitted to [123I]hippuran gamma camera renography, a quantitative evaluation of the recorded data showed that: (a) the rate constant for renal plasma clearance of [123I]hippuran was -0.166 +/- 0.043 min-1 corresponding to a hippuran plasma clearance of 518 +/- 142 ml/min per 1.73 m2; (b) the fractional renal clearance of [123I]hippuran was 0.51 +/- 0.03 and 0.49 +/- 0.03 for the left and the right kidney, respectively; and (c) the mean values for the mean transit times of [123I]hippuran through the whole kidney, the renal parenchyma, and the renal pelvis, respectively, were 4.2, 1.9, and 2.5 min. Five kidneys (in four patients) showed prolonged renal mean transit times of [123I]hippuran. Follow-up renographies were performed in three of the four children and gave normal results. Patients with renal mean transit times above the present 5% significance limit of 8.2 min should not necessarily be considered having an abnormal renal function.

Adolescent↗
PubMed1984

Imipramine treatment of painful diabetic neuropathy.

Twelve patients with severe, painful diabetic neuropathy in the lower extremities were treated with imipramine and placebo in a fixed-dose, double-blind, crossover study of five plus five weeks. Seven patients experienced notable improvement while receiving imipramine and none while receiving placebo. The rating of specific symptoms at the end of each treatment period showed a beneficial effect of imipramine on pain, paresthesia, dysesthesia, numbness, and nocturnal aggravation. The plasma levels of imipramine and its metabolite desipramine were significantly higher in patients who benefited from imipramine treatment.

Adult↗
PubMed1983

Imipramine metabolites in blood of patients during therapy and after overdose.

Plasma or serum concentrations of imipramine and five of its nonconjugated metabolites (desipramine, 2-OH-imipramine, 2-OH-desipramine, imipramine-N-oxide, and didesipramine) were followed in three cases of imipramine overdose and during steady state in 24 patients on continuous imipramine treatment. In the overdose cases the imipramine and desipramine concentrations declined monoexponentially with t 1/2s of 12 to 21 and 31 to 37 hr. The 2-OH-imipramine and 2-OH-desipramine levels were lower and declined in parallel with their corresponding parent compounds. In the patients on continuous imipramine treatment, the steady-state levels of 2-OH-imipramine and 2-OH-desipramine were very low or immeasurable (less than 15 nmol/l) in five patients. In most patients (n = 18) the hydroxymetabolite levels were much higher with 2-OH-imipramine/imipramine ratios of 0.09 to 0.45 and 2-OH-desipramine/desipramine ratios of 0.36 to 0.86. In one patient there were particularly high ratios (2-OH-imipramine/imipramine, 0.85; 2-OH-desipramine/desipramine, 1.30). The patients with very low hydroxymetabolite levels had considerably higher desipramine levels than the others, indicating that the low metabolite levels were due to poor hydroxylation. In one of these poor hydroxylators a desipramine t 1/2 of about 120 hr was estimated after imipramine discontinuation. With increased imipramine dose the 2-OH-imipramine levels tended to rise little or not at all. Imipramine-N-oxide could only be detected in the overdose cases during the first 6 to 12 hr and didesipramine was generally present only when the desipramine levels were above 200 nmol/l.

Adult↗
PubMedDate not supplied

Hepatitis C virus antibodies in homosexual men and intravenous drug users in Denmark.

In order to evaluate the role of sexual transmission and parenteral transmission of hepatitis C virus (HCV) in homosexual men and intravenous drug users (IVDU) serum samples from 147 homosexual men and 126 IVDU were tested for anti-HCV. Anti-HCV was found in two (1.4%) of the homosexual men and in 123 (98%) of IVDU. The presence of anti-HCV could not be correlated to the presence of HBV markers or HIV-antibodies. HCV is widespread among Danish IVDU. Risk of sexual transmission seems low even though sexual contact is a much more prevalent risk factor than needle sharing.

Adult↗
PubMedDate not supplied

Risk behaviours for HIV infection and sexually transmitted diseases among female sex workers from Copenhagen.

In 1990-91, 237 female sex workers from Copenhagen were enrolled in a larger study performed in 9 European countries. None of 206 women accepting serological testing was HIV-infected despite the fact that 36 (17.5%) were injecting drug users (IDU). Whereas 95% of the women always used condoms with clients over the last 6 months, this proportion was 25% and 9% respectively for casual and regular non-paying partners (P < 0.0001 for both comparisons). Those reporting at least one STD over the last year had more non-paying sexual partners than the others (P < 0.01) and the frequency of STD was lower in women who always used condoms with non-paying partners (7% vs 31%, P = 0.01). Women working on the street were more often IDU than others (78% vs 7%, P < 0.001). Independently of drug use, street prostitutes also tended to have more clients (P = 0.007) and more STD (P = 0.05). The striking differences in condom use with clients as compared to non-paying partners and the association between STD and sexual behaviours with such partners but not with clients show that specific interventions should be designed to promote safer sex with non-paying partners.

Adult↗