Biomedical subjects
B Krempien
Publications and source records attributed to B Krempien.
[Aging processes of the vessels bridging between the dura mater cerebri and the vault of the cranium. Relationship to the disease aspects of pachymeningosis hemorrhagica interna (p.h.i.)].
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[Tumor-associated hypophosphatemic osteomalacia: case report and literature review].
Despite the great number of neoplastic entities, which are able to cause this disease, "oncogenous osteomalacia" is hardly known as a paraneoplastic phenomenon. Without removing the not constantly malignant tumor as the underlying cause recovery is not possible. Until now pathogenesis is unknown. Together with a review of the literature a case report is presented, in which a malignant fibrous histiocytoma of soft tissue caused an untreatable osteomalacia. Because of failure of local tumor control prognosis in this case must be considered fatal.
[Tumor simulating manifestations of renal osteopathy: differential diagnosis and follow-up clinical examples].
The course of renal osteodystrophy possibly includes changes, which can mistakenly considered malignant. Especially dialysis-associated tumoral calcinosis may mislead to an inadequate aggressive surgical procedure. Spontaneous involution of these lesions takes place after subtotal parathyroidectomy. Brown tumors subsequent secondary hyperparathyroidism are extremely rare. During maintenance hemodialysis frequently appearing intraosseous cysts develop secondary to beta-2-microglobulin-amyloidosis. Surgery only should be performed in case of occurring pathologic fractures. Other cases are treated conservatively under continuous nephrologic supervision.
The effects of aluminium on brain gangliosides in uraemic rats treated with 24R,25-dihydroxyvitamin D3.
The administration of aluminium to uraemic rats leads to aluminium accumulation in different brain regions. Aluminium intoxication significantly alters brain gangliosides, the content of which is increased in uraemic animals. This phenomenon can be prevented by administration of 24R,25-dihydroxyvitamin D3 (24,25(OH)2D3). Our results could possibly find an application in the prevention of aluminium-induced encephalopathy in patients on haemodialysis.